Late-long-term potentiation magnitude, but not Aβ levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease

Sex differences in the IntelliCage and the Morris water maze in the APP/PS1 mouse model of amyloidosis

(2021) Marc A. Mifflin et al.   NEUROBIOLOGY OF AGING

A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission

(2021) Tao Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant

(2020) Marc D. Tambini et al.   Scientific Reports

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

(2020) Marc D Tambini et al.   eLife

Knock-in rats with homozygous PSEN1L435F Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43

(2020) Marc D. Tambini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

(2020) Siqiang Ren et al.   eLife

Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage

(2019) Wen Yao et al.   JOURNAL OF NEUROSCIENCE

Facilitation of glutamate, but not GABA , release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP

(2019) Marc D. Tambini et al.   AGING CELL

Differences Between Women and Men in Incidence Rates of Dementia and Alzheimer’s Disease

(2018) Christopher R. Beam et al.   JOURNAL OF ALZHEIMERS DISEASE

Prefrontal–hippocampal interactions in episodic memory

(2017) Howard Eichenbaum   NATURE REVIEWS NEUROSCIENCE

Cognitive deficits in single App knock-in mouse models

(2016) Akira Masuda et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

(2015) Tomas Fanutza et al.   eLife

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1

(2012) Bernhard M. Kohli et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

(2012) Robert Tamayev et al.   Molecular Neurodegeneration

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

(2011) Toshihiro Endo et al.   BEHAVIOURAL BRAIN RESEARCH

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Amyloid Precursor Protein Revisited

(2011) Qinxi Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles

(2011) Teja W. Groemer et al.   PLoS One

Conditioned response suppression in the IntelliCage: assessment of mouse strain differences and effects of hippocampal and striatal lesions on acquisition and retention of memory

(2010) Vootele Voikar et al.   BEHAVIOURAL BRAIN RESEARCH

Identification of NEEP21 as a  -Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing In Vitro

(2010) E. M. Norstrom et al.   JOURNAL OF NEUROSCIENCE

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

(2010) R. Tamayev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BACE1 Knock-Outs Display Deficits in Activity-Dependent Potentiation of Synaptic Transmission at Mossy Fiber to CA3 Synapses in the Hippocampus

(2008) H. Wang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE