Journal
CELL CALCIUM
Volume 58, Issue 1, Pages 11-17Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2014.11.001
Keywords
Mitochondria; Calcium; Organelle; Signaling; Cell death
Categories
Funding
- European Union (ERC mitoCalcium) [294777]
- Italian Ministries of Health (Ricerca Finalizzata)
- Education, University and Research (PRIN. FIRB)
- NIH [1P01AG025532-01A1]
- Cariparo Foundation
- Cariplo Foundation
- Italian Association for Cancer Research (AIRC)
- Telethon-Italy [GPP10005A, GGP11082B]
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The long awaited molecular identification of the mitochondrial calcium uniporter (MCU) in 2011 has opened an exciting phase in the study of mitochondrial calcium homeostasis. On the one hand, MCU proved to be the core of a complex signaling system, composed of a channel moiety (MCU itself and the related MCUb protein) and a family of essential regulators (the MICUs, MCUR, EMRE). On the other hand, the availability of molecular information and tools opened the possibility of directly altering mitochondrial calcium homeostasis in cell cultures or intact organisms, thus obtaining new insight into its role in physiological and pathological events. We will review here these exciting advancements, summarizing the current knowledge of the molecular composition of the MCU complex and of its role in shaping mitochondrial and cytosolic [Ca2+] signals. Published by Elsevier Ltd.
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