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Biochemistry & Molecular Biology
Juan A. Estrada, Norio Hotta, Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Gary A. Iwamoto, Scott A. Smith, Wanpen Vongpatanasin, Masaki Mizuno
Summary: Insulin not only regulates glucose and/or lipid metabolism but also modulates brain neural activity by inhibiting neuronal excitability. Blocking insulin receptors in the nucleus tractus solitarius can enhance the exercise pressor reflex, suggesting a regulatory role of insulin in this process.
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Physiology
Jian Cui, Zhaohui Gao, Cheryl Blaha, Jonathan Carter Luck, Kristen Brandt, Lawrence Sinoway
Summary: The study found that moderate whole body heat stress can attenuate the sympathetic nervous system and blood pressure responses to exercise in older healthy individuals. Additionally, limb heating has minimal impact on physiological responses during exercise.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Nace Zidar, Tihomir Tomasic, Danijel Kikelj, Martina Durcik, Jan Tytgat, Steve Peigneur, Marc Rogers, Alexander Haworth, Robert W. Kirby
Summary: Voltage-gated sodium channels (Navs) play a crucial role in neurotransmission and their dysfunction is associated with various neurological disorders. In this study, a new series of aryl and acylsulfonamides were discovered as state-dependent inhibitors of Nav1.3 channels. These compounds displayed strong selective activity against the inactivated state of the Nav1.3 channel, with weaker activity against Nav1.5 and Nav1.7 channels. These findings provide a valuable tool for further evaluation of Nav1.3 channel as a potential drug target.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Juan Hong, Shubin Fu, Lie Gao, Yanhui Cai, Eric Lazartigues, Han-Jun Wang
Summary: The dysfunction of voltage-gated potassium (Kv) channels in dorsal root ganglions plays a critical role in mediating the exaggerated exercise pressor reflex and muscle afferent sensitization in chronic heart failure (CHF) patients. Manipulating Kv channels in DRG neurons could be a potential new approach to reduce sympathoexcitation and improve exercise intolerance in CHF, ultimately enhancing quality of life and reducing mortality.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Rehabilitation
Justin D. Sprick, Monica C. Serra, Alice S. Ryan, Yunxiao Li, Jeanie Park
Summary: Stroke survivors exhibit greater increases in systolic blood pressure during maximal treadmill exercise compared to controls, and these responses do not appear to be related to systemic inflammation. Future work should seek to delineate the mechanisms responsible for exaggerated blood pressure responses during exercise in stroke.
TOPICS IN STROKE REHABILITATION
(2021)
Article
Nutrition & Dietetics
Amane Hori, Daisuke Hasegawa, Kenichi Suijo, Keita Nishigaki, Koji Ishida, Norio Hotta
Summary: The study found that exercise training with BFR technique intensifies blood pressure response and is associated with muscle metaboreflex, potentially increasing the risk of adverse cardiovascular events.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Darren S. Finkelstein, J. Du Bois
Summary: This study focused on the selective labeling of voltage-gated sodium channels (NaVs) using chemical reagents based on saxitoxin. The results showed that a STX-maleimide-coumarin derivative was most effective at blocking Na+ conductance. These findings are guiding the development of next-generation tool compounds for selective modification of NaVs expressed in cell membranes.
Article
Pharmacology & Pharmacy
Benjamin Hackl, Peter Lukacs, Janine Ebner, Krisztina Pesti, Nicholas Haechl, Matyas C. Foeldi, Elena Lilliu, Klaus Schicker, Helmut Kubista, Anna Stary-Weinzinger, Karlheinz Hilber, Arpad Mike, Hannes Todt, Xaver Koenig
Summary: Ivabradine acts as an atypical inhibitor of voltage-gated sodium channels, affecting heart rate and cardiac conduction system, which may provide potential basis for anti-arrhythmic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sascha Ketelhut, Reinhard G. Ketelhut, Eva Kircher, Lisa Roeglin, Kuno Hottenrott, Anna Lisa Martin-Niedecken, Kerstin Ketelhut
Summary: This study compared the effects of an innovative exergame and a typical endurance training on cardiovascular reactivity. The results showed that the exergame session induced a higher exercise stimulus and attenuated hemodynamic stress reactivity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Andrei M. Gigolaev, Vladislav A. Lushpa, Ernesto L. Pinheiro-Junior, Valentin M. Tabakmakher, Steve Peigneur, Anastasija A. Ignatova, Alexey V. Feofanov, Roman G. Efremov, Konstantin S. Mineev, Jan Tytgat, Alexander A. Vassilevski
Summary: Among voltage-gated potassium channel (KV) isoforms, KV1.6 is widely distributed in the nervous system. Researchers have designed a peptide with high affinity and selectivity for KV1.6, which could be useful for studying KV1.6 and its functions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Magdalena Bachmann, Andrea Rossa, Tatiana Varanita, Bernard Fioretti, Lucia Biasutto, Stefan Milenkovic, Vanessa Checchetto, Roberta Peruzzo, Syed A. Ahmad, Sameer H. Patel, Robert Lukowski, Michael J. Edwards, Matteo Ceccarelli, Erich Gulbins, Mario Zoratti, Andrea Mattarei, Ildiko Szabo
Summary: This study reports the synthesis and characterization of two mitochondria-targeted TRAM-34 derivatives, which induce cancer cell death and reduce cancer cell migration, showing potential against tumor growth and metastasis.
CELL DEATH & DISEASE
(2022)
Article
Physiology
Lu Qin, Jianhua Li
Summary: This study investigated the role of HIF-1α in regulating the response of arterial blood pressure during muscle contraction in rats with femoral artery occlusion-induced PAD. The results suggest that inhibition of HIF-1α alleviates the exaggeration of the exercise pressor reflex in rats under ischemic circumstances, indicating a potential therapeutic target for PAD.
PHYSIOLOGICAL REPORTS
(2021)
Article
Physiology
Qin Li, Lu Qin, Jianhua Li
Summary: In this study, we found that IL-6 plays a role in regulating the exaggerated exercise pressor reflex in rats with PAD induced by femoral artery ligation, primarily through Kv4 channels in muscle sensory neurons, indicating the importance of IL-6 trans-signaling pathway in PAD.
PHYSIOLOGICAL REPORTS
(2021)
Article
Physiology
Farid Al-Dhuhli, Sultan Al-Siyabi, Hamed Al-Maamari, Said Al-Farsi, Sulayma Albarwani
Summary: Exercise training for 10 weeks induced an increase in constriction and a decrease in relaxation of mesenteric arteries, which may help redirect blood flow to metabolically active tissues during acute exercise.
PHYSIOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Lu Qin, Jianhua Li
Summary: In patients with peripheral artery disease, reduced blood supply to the lower limbs leads to severe limb ischemia, enhancing pain sensitivity in the lower limbs. This results in intermittent claudication, with increased painful perception during activity and relief at rest. Limb ischemia also amplifies autonomic responses during exercise.
NEURAL REGENERATION RESEARCH
(2021)
Article
Physiology
Audrey J. Stone, Steven W. Copp, Joyce S. Kim, Marc P. Kaufman
JOURNAL OF APPLIED PHYSIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Steven W. Copp, Joyce S. Kim, Victor Ruiz-Velasco, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Article
Neurosciences
Mohamed Farrag, Julie K. Drobish, Henry L. Puhl, Joyce S. Kim, Paul B. Herold, Marc P. Kaufman, Victor Ruiz-Velasco
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Neurosciences
Jonathan E. Harms, J. Matthew Kuczmarski, Joyce S. Kim, Gail D. Thomas, Marc P. Kaufman
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Physiology
Joyce S. Kim, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Physiology
Guillaume P. Ducrocq, Juan A. Estrada, Joyce S. Kim, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Physiology
Joyce S. Kim, Jonathan E. Harms, Victor Ruiz-Velasco, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Review
Neurosciences
Matthew D. Coates, Joyce S. Kim, Nurgul Carkaci-Salli, Kent E. Vrana, Walter A. Koltun, Henry L. Puhl, Sanjib D. Adhikary, Piotr K. Janicki, Victor Ruiz-Velasco
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Guillaume P. Ducrocq, Joyce S. Kim, Juan A. Estrada, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Joyce S. Kim, Guillaume P. Ducrocq, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Guillaume P. Ducrocq, Joyce S. Kim, Juan A. Estrada, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Physiology
Juan A. Estrada, Guillaume P. Ducrocq, Joyce S. Kim, Marc P. Kaufman
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Laura Anselmi, Joyce S. Kim, Marc P. Kaufman, Shouhao Zhou, Victor Ruiz-Velasco
Summary: This study investigates the modulation of calcium channel currents in muscle neurons by serotonin. The findings suggest that the 5-HT1A receptor subtype plays a crucial role in this process. Additionally, selective activation of the 5-HT1A receptor is found to decrease pressor responses induced by acid stimuli. These findings contribute to a better understanding of the role of serotonin under mechanical and inflammatory stimuli.
MOLECULAR PHARMACOLOGY
(2022)
Article
Neurosciences
Joyce S. Kim, Hui Sun, Sonya Meeker, Bradley J. Undem
Summary: The study evaluated the influence of Na(V)1.9 on the activation of airway vagal nodose C-fibres induced by inflammatory mediators. It was found that Na(V)1.9 played a crucial role in mediating the activation of C-fibres by G protein-coupled receptors and ionotropic receptors. However, Na(V)1.9 was not involved in the response to rapid punctate mechanical stimuli.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)