Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations

HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes

(2015) Nuno Guimarães-Camboa et al.   DEVELOPMENTAL CELL

Sex-Specific Placental Responses in Fetal Development

(2015) Cheryl S. Rosenfeld   ENDOCRINOLOGY

Bisphenol A Exposure Disrupts Metabolic Health Across Multiple Generations in the Mouse

(2015) Martha Susiarjo et al.   ENDOCRINOLOGY

Glucocorticoids as regulatory signals during intrauterine development

(2015) Abigail L. Fowden et al.   EXPERIMENTAL PHYSIOLOGY

Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensitivity in rat offspring, which is exacerbated by a postnatal high-fat diet

(2015) Emelie M. Gårdebjer et al.   FASEB JOURNAL

The omniscient placenta: Metabolic and epigenetic regulation of fetal programming

(2015) Bridget M. Nugent et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Regional differences in the placental levels of oxidative stress markers in pre-eclampsia

(2015) Akriti S. Sahay et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Sexual dimorphism in miR-210 expression and mitochondrial dysfunction in the placenta with maternal obesity

(2015) S Muralimanoharan et al.   INTERNATIONAL JOURNAL OF OBESITY

Relationships Among Stress Coping Styles and Pregnancy Complications Among Women Exposed to Hurricane Katrina

(2015) Olurinde Oni et al.   JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING

Fathers That Are Born Small Program Alterations in the Next-Generation Preimplantation Rat Embryos

(2015) Jordanna S Master et al.   JOURNAL OF NUTRITION

Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy

(2015) Hannah Matheson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Maternal obesity in females born small: Pregnancy complications and offspring disease risk

(2015) Dayana Mahizir et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Risk of Gestational Diabetes Mellitus Following Bereavement: A Cohort Study from Denmark and Sweden

(2015) Krisztina D. László et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Paternal line multigenerational passage of altered risk assessment behavior in female but not male rat offspring of mothers fed a low protein diet

(2015) L.A. Reyes-Castro et al.   PHYSIOLOGY & BEHAVIOR

Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA

(2015) D. Schneider et al.   PLACENTA

Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality

(2015) R.N. Schlegel et al.   PLACENTA

Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances

(2015) Josep C. Jimenez-Chillaron et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Puberty onset is delayed following uteroplacental insufficiency and occurs earlier with improved lactation and growth for pups born small

(2015) Tania Romano et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Placental Adaptations in Growth Restriction

(2015) Song Zhang et al.   Nutrients

Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

(2015) Jereme G. Spiers et al.   Frontiers in Neuroscience

Impaired mitochondrial function in human placenta with increased maternal adiposity

(2014) James Mele et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ancestral exposure to stress epigenetically programs preterm birth risk and adverse maternal and newborn outcomes

(2014) Youli Yao et al.   BMC Medicine

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

(2014) Débora Martínez et al.   Cell Metabolism

Maternal Diet-induced Obesity Programs Cardiovascular Dysfunction in Adult Male Mouse Offspring Independent of Current Body Weight

(2014) Heather L. Blackmore et al.   ENDOCRINOLOGY

Maternal Vitamin D Status and the Risk of Mild and Severe Preeclampsia

(2014) Lisa M. Bodnar et al.   EPIDEMIOLOGY

Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring

(2014) Sheau-Fang Ng et al.   FASEB JOURNAL

Transgenerational effects of social stress on social behavior, corticosterone, oxytocin, and prolactin in rats

(2014) Jessica A. Babb et al.   HORMONES AND BEHAVIOR

Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner

(2014) J. S. M. Cuffe et al.   JOURNAL OF PHYSIOLOGY-LONDON

Integrative transcriptome meta-analysis reveals widespread sex-biased gene expression at the human fetal-maternal interface

(2014) S. Buckberry et al.   MOLECULAR HUMAN REPRODUCTION

Recurring Complications in Second Pregnancy

(2014) Jacob Alexander Lykke et al.   OBSTETRICS AND GYNECOLOGY

Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction

(2014) Christopher L. Howerton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parenting from before conception

(2014) M. Lane et al.   SCIENCE

Sex differences in the developmental programming of hypertension

(2013) N. B. Ojeda et al.   Acta Physiologica

Acute Kidney Injury in Pregnancy—Current Status

(2013) Anjali Acharya et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Cardiovascular risk factors in women who had hypertensive disorders late in pregnancy: a cohort study

(2013) Wietske Hermes et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Offspring’s blood pressure and metabolic phenotype after exposure to gestational hypertension in utero

(2013) Satu Miettola et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Psychosocial Stress Related to the Loss of a Close Relative the Year Before or During Pregnancy and Risk of Preeclampsia

(2013) Krisztina D. László et al.   HYPERTENSION

Transgenerational metabolic outcomes associated with uteroplacental insufficiency

(2013) Melanie Tran et al.   JOURNAL OF ENDOCRINOLOGY

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta

(2013) E.M. Gårdebjer et al.   PLACENTA

Advanced Maternal Age and Adverse Pregnancy Outcome: Evidence from a Large Contemporary Cohort

(2013) Louise C. Kenny et al.   PLoS One

Prenatal Exposure to Dexamethasone in the Mouse Alters Cardiac Growth Patterns and Increases Pulse Pressure in Aged Male Offspring

(2013) Lee O'Sullivan et al.   PLoS One

Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats

(2013) Linda A. Gallo et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Developmental programming of cardiovascular disease by prenatal hypoxia

(2013) D. A. Giussani et al.   Journal of Developmental Origins of Health and Disease

Normal lactational environment restores cardiomyocyte number after uteroplacental insufficiency: implications for the preterm neonate

(2012) M. Jane Black et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fetal growth restriction: current knowledge to the general Obs/Gyn

(2012) Luciano Marcondes Machado Nardozza et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Short- and long-term effects of exposure to natural and synthetic glucocorticoids during development

(2012) Reetu R Singh et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation

(2012) Denise S. Fernandez-Twinn et al.   ENDOCRINOLOGY

Early first-trimester crown-rump length measurements in male and female singleton fetuses in IVF pregnancies

(2012) Avi Ben-Haroush et al.   Journal of Maternal-Fetal & Neonatal Medicine

Women Born Preterm or with Inappropriate Weight for Gestational Age Are at Risk of Subsequent Gestational Diabetes and Pre-Eclampsia

(2012) Rasmus á Rogvi et al.   PLoS One

Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress

(2012) Dino A. Giussani et al.   PLoS One

Effect of Pregnancy for Females Born Small on Later Life Metabolic Disease Risk

(2012) Melanie Tran et al.   PLoS One

Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats

(2011) Rhianna C. Laker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association of Maternal Diabetes Mellitus in Pregnancy With Offspring Adiposity Into Early Adulthood

(2011) Debbie A. Lawlor et al.   CIRCULATION

Mother's body size and placental size predict coronary heart disease in men

(2011) J. G. Eriksson et al.   EUROPEAN HEART JOURNAL

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

(2011) C. P. Morgan et al.   JOURNAL OF NEUROSCIENCE

Cardio-renal and metabolic adaptations during pregnancy in female rats born small: implications for maternal health and second generation fetal growth

(2011) Linda A. Gallo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse

(2011) J.S.M. Cuffe et al.   PLACENTA

The lifespan of men and the shape of their placental surface at birth

(2011) D.J.P. Barker et al.   PLACENTA

The dynamic stress-induced “O-GlcNAc-ome” highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways

(2010) Natasha E. Zachara et al.   AMINO ACIDS

Mechanisms involved in the developmental programming of adulthood disease

(2010) Matthew J. Warner et al.   BIOCHEMICAL JOURNAL

Association Between Placental Morphology and Childhood Systolic Blood Pressure

(2010) Xiaozhong Wen et al.   HYPERTENSION

Thyroid Dysfunction and Autoantibodies during Pregnancy as Predictive Factors of Pregnancy Complications and Maternal Morbidity in Later Life

(2010) Tuija Männistö et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Liver disease in pregnancy

(2010) Deepak Joshi et al.   LANCET

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Cross-fostering and improved lactation ameliorates deficits in endocrine pancreatic morphology in growth-restricted adult male rat offspring

(2010) A. L. Siebel et al.   Journal of Developmental Origins of Health and Disease

Placental Weight Relative to Birth Weight and Long-term Cardiovascular Mortality: Findings From a Cohort of 31,307 Men and Women

(2009) K. R. Risnes et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Boys live dangerously in the womb

(2009) Johan G. Eriksson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Toxic Effects of Hyperglycemia Are Mediated by the Hexosamine Signaling Pathway and O-Linked Glycosylation in Early Mouse Embryos1

(2009) Marie Pantaleon et al.   BIOLOGY OF REPRODUCTION

In preeclampsia, the placenta grows slowly along its minor axis

(2009) Eero Kajantie et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Future risk of diabetes in mother and child after gestational diabetes mellitus

(2009) Peter Damm   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats

(2009) Karen M. Moritz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Review: Sex and the Human Placenta: Mediating Differential Strategies of Fetal Growth and Survival

(2009) V.L. Clifton   PLACENTA

SHEEP MODELS OF INTRAUTERINE GROWTH RESTRICTION: FETAL ADAPTATIONS AND CONSEQUENCES

(2008) Janna L Morrison   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring

(2008) Andrew L. Siebel et al.   ENDOCRINOLOGY

Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats

(2008) Mary E. Wlodek et al.   KIDNEY INTERNATIONAL

What is an epigenetic transgenerational phenotype?

(2007) Michael K. Skinner   REPRODUCTIVE TOXICOLOGY