Article
Nutrition & Dietetics
Nicholas A. Hulett, Rebecca L. Scalzo, Jane E. B. Reusch
Summary: This review examines the physiological mechanisms of glucose uptake in healthy individuals and individuals with type 2 diabetes, highlighting insulin resistance as a key factor. The review also emphasizes the importance of exercise in enhancing glucose uptake.
Article
Nutrition & Dietetics
Yuge Jiang, Chuanxing Feng, Yonghui Shi, Xingran Kou, Guowei Le
Summary: Eugenol has been found to have potential protective effects on muscle function and prevention of muscle inflammation. It can lower blood glucose and insulin resistance, reduce muscle inflammation induced by a high-fat diet and streptozocin injection, and prevent muscle weakness and atrophy. This may be explained by the increased translocation of GLUT4 and phosphorylation of AMPK in skeletal muscle, resulting in enhanced glucose uptake.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Yuki Suzuki, Kenji Kikuchi, Keiko Numayama-Tsuruta, Takuji Ishikawa
Summary: The mechanical relationship between glucose uptake and intestinal flows is investigated in this study. The findings suggest that animals with gastrointestinal motility utilize the reciprocating intestinal flows caused by peristalsis to enhance nutrient absorption.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Arkady Uryash, Jordan Umlas, Alfredo Mijares, Jose A. Adams, Jose R. Lopez
Summary: T2D is a global public health problem with increasing number of affected individuals. Treating db/db mice with pGz has shown beneficial effects, including reducing calcium overload, enhancing muscle glucose transport, decreasing oxidative stress, pro-inflammatory cytokines, and improving muscle strength.
Article
Biotechnology & Applied Microbiology
Erika Steele, Hana D. Alebous, Macy Vickers, Mary E. Harris, Margaret D. Johnson
Summary: ** The study demonstrated that Myo-Inositol Phosphate Synthase (MIP) can act as a growth factor in intercellular locations, promoting cellular proliferation of cells requiring inositol. This suggests previously unknown functions for MIP and advances current knowledge on spatial control of inositol phosphate biosynthesis. Moreover, it identified an extracellular vesicle capable of synthesizing and transporting inositol phosphate, which could enhance current inositol phosphate therapeutics.
MICROBIAL CELL FACTORIES
(2021)
Article
Biochemistry & Molecular Biology
Manana Kandashvili, Georgi Gamkrelidze, Lia Tsverava, Tamar Lordkipanidze, Eka Lepsveridze, Vincenzo Lagani, Maia Burjanadze, Manana Dashniani, Merab Kokaia, Revaz Solomonia
Summary: This study shows that long-term treatment with myo-inositol (MI) can prevent epileptogenesis and improve cognitive comorbidities associated with epilepsy. The effects of MI treatment on brain activity and cell loss persist even after treatment cessation, making it a potential candidate for preventing epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Lyudmila V. Gromova, Alexandr S. Polozov, Elizaveta V. Savochkina, Anna S. Alekseeva, Yulia V. Dmitrieva, Oleg V. Kornyushin, Andrey A. Gruzdkov
Summary: The study found that in young Wistar rats with type 2 diabetes and impaired glucose tolerance, the ability of the small intestine to absorb glucose increased, while there were significant changes in enzyme activity in the intestine.
Article
Food Science & Technology
Pedro Castillo, Mariona Palou, David Otero, Paula Nunez, Andreu Palou, Catalina Pico
Summary: This study demonstrates that supplementation with myo-inositol during lactation can improve metabolic health in male rats and reverse metabolic alterations caused by gestational calorie restriction. Myo-inositol supplementation lowered triglyceride and insulin levels, and improved insulin resistance in male rats. Further investigation is needed to determine the effects in females.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Medicine, General & Internal
Soana K. Motuhifonua, Luling Lin, Jane Alsweiler, Tineke J. Crawford, Caroline A. Crowther
Summary: The study found that dietary supplementation with myo-inositol during pregnancy can reduce the incidence of gestational diabetes, hypertensive disorders of pregnancy, and preterm birth. However, it may not reduce the risk of a large-for-gestational-age infant. The evidence is limited due to small sample sizes and regional specificity.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Debora Santos Rocha, Maiza Von Dentz, Jorge Felipe Argenta Model, Everton Lopes Vogt, Renata Ohlweiler, Matheus Vieira Lima, Samir Khal de Souza, Luiz Carlos Kucharski
Summary: This study investigates the peculiarities of glucose metabolism in female rats subjected to two classic experimental diabetes protocols. The results show that high dosage of single streptozotocin leads to lower glycogen levels in the liver and muscle, while low dosage of streptozotocin reduces lipid synthesis in the liver. After 30 days, diabetic animals have higher blood glucose levels but no decrease in insulin levels, no effects on muscle glucose uptake, and no increase in hepatic gluconeogenesis.
BIOMEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Min Zhang, Hongyan Yang, Erwan Yang, Jia Li, Ling Dong
Summary: Berberine reduces intestinal glucose absorption through inhibiting the IGF-1R-PLC-beta 2-GLUT2 signal pathway, improving postprandial hyperglycemia and enhancing insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Siqi Xie, MingChang Wang, Bin Zhang, ShanGeng Weng
Summary: Duodenal-jejunal bypass surgery can reduce blood glucose levels in type 2 diabetic rats by regulating the expression of bile acid receptors in the liver and intestinal tissues, leading to lower levels of blood lipids.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Dhani Raj Chhetri, Sachina Yonzone, Raksha Mukhia
Summary: L-myo-inositol-1-phosphate synthase (MIPS) and its product, free myo-inositol, have been isolated and characterized from Sphagnum junghuhnianum moss. The enzyme shows exclusive substrate specificity for D-glucose-6-phosphate and exhibits optimal activity at pH 7.0 and 30 degrees C. Inhibition and stimulation of the enzyme activity were observed with different ions and cofactors, with Hg2+ showing the highest inhibition. The enzyme also exhibits characteristics of both Class-II and Class-III aldolase.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Review
Endocrinology & Metabolism
Xintong Hou, Dan Yang, Guimei Yang, Mengnan Li, Jian Zhang, Jiaxin Zhang, Yi Zhang, Yunfeng Liu
Summary: This review summarizes the physiological significance of vasoactive intestinal peptide (VIP) in glucose homeostasis and the potential therapeutic value of VPAC2-selective agonists in type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yaping Liu, Ze Xu, Haoyue Huang, Yuan Xue, Dongdong Zhang, Yujing Zhang, Wenjie Li, Xing Li
Summary: Fucoidan has the potential to prevent type 2 diabetes by improving intestinal barrier and inflammation, and regulating glucose metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Plant Sciences
Adeline Lum Nde, Chika I. Chukwuma, Ochuko L. Erukainure, Maria S. Chukwuma, Motlalepula G. Matsabisa
Summary: Senna occidentalis contains various phytochemical constituents that have anti-diabetic, hypoglycemic, anti-hyperlipidemic, and antioxidative effects. Research indicates that different parts of the plant exert anti-diabetic effects by regulating blood glucose, lipid profile, antioxidant status, and islet function.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eunice A. Akuru, Chika Chukwuma, Chika E. Oyeagu, Ochuko L. Erukainure, Boitumelo Mashile, Reaotshepa Setlhodi, Samson S. Mashele, Tshepiso J. Makhafola, Jeremiah O. Unuofin, Taiwo O. Abifarin, Thando C. Mpendulo
Summary: The study evaluates the antioxidant, nutritional, and phytochemical profiles of the Wonderful pomegranate peel, showing its potential as a source of functional nutrients and phenolic antioxidants. The peel exhibits potent antioxidant activities, preventing oxidative stress-induced damage in liver cells and tissues. Additionally, metabolomics analysis reveals beneficial metabolic alterations following treatment with the peel extract, suggesting its potential in improving overall body function and mitigating hepatic oxidative damage.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Plant Sciences
Olajumoke A. Oyebode, Ochuko L. Erukainure, Anil A. Chuturgoon, Terisha Ghazi, Pragalathan Naidoo, Chika I. Chukwuma, Md. Shahidul Islam
Summary: The study shows that the butanol fraction of Bridelia ferruginea leaves has hepato-protective effects in diabetic rats, with positive impacts on GLUT4 expression and metabolic pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Ochuko L. Erukainure, Motlalepula G. Matsabisa, Veronica F. Salau, Kolawole A. Olofinsan, Sunday O. Oyedemi, Chika I. Chukwuma, Adeline Lum Nde, Md. Shahidul Islam
Summary: Reduced glucose uptake and utilization has been linked to obesity and its complications. This study found that cannabinoid-stimulated glucose uptake increased antioxidative activities, modulated cholinergic and purinergic dysfunctions, and improved glucose-lipid homeostasis in adipose tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Correction
Plant Sciences
Ochuko L. Erukainure, Omamuyovwi M. Ijomone, Chika I. Chukwuma, Xin Xiao, Veronica F. Salau, Md Shahidul Islam
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Godfrey R. Matowane, Limpho M. Ramorobi, Samson S. Mashele, Susanna L. Bonnet, Anwar E. M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola, Chika Chukwuma
Summary: Complexation of zinc(II) with ferulic acid improves glycaemic control and antioxidant potential.
Article
Plant Sciences
Ochuko L. Erukainure, Sunelle Rademan, Joseph O. Erhabor, Chika I. Chukwuma, Adeline Lum Nde, Motlalepula G. Matsabisa
Summary: This study investigated the protective effects of Cannabis sativa on the regulation of purinergic and glucogenic enzymes. Results showed that the extracts of Cannabis sativa can reduce cellular damage caused by oxidative stress and help maintain redox balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Limpho M. Ramorobi, Godfrey R. Matowane, Samson S. Mashele, Susanna L. Bonnet, Anwar E. M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola, Chika Chukwuma
Summary: This study investigated the complexation-mediated synergistic interaction between zinc(II) and p-coumaric acid in the management of diabetes and oxidative stress. The results showed that the complex formed by zinc(II) and p-coumaric acid was more effective in antioxidant and antihyperglycemic activities compared to p-coumaric acid alone. The complex exhibited strong inhibitory effects on lipid peroxidation and GSH depletion, and enhanced glucose uptake and hexokinase activity. These findings suggest that zinc(II) complexation may be an important approach in improving the application potential of p-coumaric acid in the management of diabetes and oxidative stress.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Godfrey R. Matowane, Limpho M. Ramorobi, Samson S. Mashele, Susanna L. Bonnet, Anwar E. M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: This study aimed to synthesize a novel medicinal Zn(II) complex with enhanced antioxidant and anti-hyperglycemic properties. The results showed that the complex exhibited stronger antioxidant and anti-hyperglycemic activity compared to caffeic acid alone and had better interaction with insulin signaling target proteins. This finding has potential medicinal relevance.
MEDICINAL CHEMISTRY
(2023)
Article
Food Science & Technology
Reaotshepa Setlhodi, Boitumelo Mashile, Gloria O. Izu, Sefater Gbashi, Samson S. Mashele, Susanna L. Bonnet, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: Ellagitannins are the main bioactive tannins in pomegranate peel. This study used advanced chemometrics models to determine the solvent extraction (methanol, ethanol, acetone, water) that yields the highest antioxidant and ellagitannins profiles. Acetone extraction had the highest total phenol and flavonoid contents, while methanol extraction had the strongest radical scavenging activity. The models adequately characterized and predicted the variation and patterns in the antioxidant and ellagitannins datasets.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Reaotshepa Setlhodi, Boitumelo Mashile, Gloria O. Izu, Sefater Gbashi, Samson S. Mashele, Susanna L. Bonnet, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: This study used advanced chemometrics models to determine the influence of different extraction temperatures on the antioxidant profile and ellagitannins recovery of pomegranate peel extract. Extraction at 78 degrees Celsius showed the highest antioxidant activity and ellagitannins content. Pearson's bivariate correlation showed a strong positive correlation between ellagitannins and the anti-lipid peroxidative profile of the extract. The PCA and OPLS models adequately characterized and predicted the variation and patterns in the antioxidant and phytochemical datasets. OPLS biplot showed a distinct clustering pattern around 78 degrees Celsius extraction temperature, indicating the influence of ellagitannins on the antioxidant profile at this temperature.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Limpho M. Ramorobi, Godfrey R. Matowane, Samson S. Mashele, Ochuko L. Erukainure, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: Zinc(II) and syringic acid were investigated for their antidiabetic and antioxidative effects in diabetic rats. The complex of zinc(II) and syringic acid reduced polyphagia, polydipsia, and weight loss in diabetic rats. The complex enhanced the anti-hyperglycemic action of zinc(II) and syringic acid, reduced lipid peroxidation, and increased antioxidant enzyme activity.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Chemistry, Medicinal
Veronica F. Salau, Ochuko L. Erukainure, Gideon Ayeni, Collins U. Ibeji, Tosin A. Olasehinde, Chika I. Chukwuma, Neil A. Koorbanally, Md. Shahidul Islam
Summary: The neuroprotective effect of betulinic acid against oxidative neurotoxicity induced by iron was investigated in isolated rat brains. The induction of oxidative neurotoxicity resulted in suppressed antioxidant levels and increased levels of reactive oxygen species. Treatment with betulinic acid reversed these effects and restored the depleted compounds. Pathway analysis revealed the activation of neuroprotective metabolic pathways upon betulinic acid treatment. Molecular docking showed a strong binding affinity between betulinic acid and ATPase. These findings suggest that betulinic acid confers neuroprotection by restoring redox balance and modulating various metabolic pathways.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Food Science & Technology
Boitumelo Mashile, Reaotshepa Setlhodi, Gloria O. Izu, Ochuko L. Erukainure, Samson S. Mashele, Tshepiso J. Makhafola, Kenneth C. Eze, Chika I. Chukwuma
Summary: This study optimized the extraction of bioactive ellagitannins and punicalagin from pomegranate peel using temperature-dependent extraction. The extract obtained at 78 degrees C had the highest content of phenols, flavonoids, tannins, and punicalagin, showing the strongest antioxidant and glycaemic control properties. The purified tannin from the extract at 78 degrees C exhibited better anti-lipid peroxidation and glucose modulatory effects compared to the crude extract and purified punicalagin.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Chika Chukwuma, Md Shahidul Islam
Summary: Cinnamic acid has anti-diabetic properties by enhancing glucose uptake, improving redox imbalance and proteolysis, and modulating glucose-lipid metabolism.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)