Review
Food Science & Technology
Nawel Benbouguerra, Ruth Hornedo-Ortega, Francois Garcia, Toni El Khawand, Cedric Saucier, Tristan Richard
Summary: Stilbenes are natural phenolic compounds synthesized by plants in response to stress. They are found in grape berries and wine, with potential anti-obesity effects. Optimized analytical methods are essential for accurate detection and quantification of stilbenes.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Pedro Manuel Rodriguez-Munoz, Juan Manuel Carmona-Torres, Cristina Rivera-Picon, Ignacio Morales-Cane, Fabio Fabbian, Roberto Manfredini, Maria Aurora Rodriguez-Borrego, Pablo Jesus Lopez-Soto
Summary: The study found that the majority of Spanish university students consume alcohol, while smoking rates are low, showing a high adherence to the Mediterranean diet as part of a healthy lifestyle associated with less risky alcohol consumption. Unhealthy eating habits may induce risky alcohol consumption behaviors.
Article
Food Science & Technology
Armachius James, Ting Yao, Hengming Ke, Yousheng Wang
Summary: Microbial communities in winemaking have a diverse impact on the fermentation process, flavor, aroma, and functional components of wine. The management of microbiota can enhance wine production and contribute to the health benefits associated with moderate wine consumption. This review focuses on the contributions of wine microbiota to functional components and highlights the role of different yeasts and bacteria in winemaking.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Renan Dal-Fabbro, Leopoldo Cosme-Silva, Fernanda Rezende Silva Martins de Oliveira, Leticia Cabrera Capalbo, Flavia Alfredo Plazza, Edilson Ervolino, Luciano Tavares Angelo Cintra, Joao Eduardo Gomes-Filho
Summary: The study showed that red wine consumption before induction of apical periodontitis in rats can reduce inflammation, TRAP marking, and periapical bone resorption, while alcohol has the opposite effect. Administration of resveratrol and quercetin was more effective in reducing inflammation and periapical bone resorption in apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Carmine Negro, Alessio Aprile, Andrea Luvisi, Luigi De Bellis, Antonio Miceli
Summary: This study evaluated the polyphenolic compounds and antioxidant activity in pomaces from three grape varieties in Southern Italy, finding that Primitivo pomace had the highest antioxidant activity, followed by Negroamaro. Additionally, pomaces from traditional Apulian vines showed higher antioxidant activities compared to Cabernet Sauvignon due to elevated levels of active polyphenolic substances.
Article
Agronomy
Mattia Rapa, Vanessa Giannetti, Maurizio Boccacci Mariani
Summary: This study analyzed the physiochemical and polyphenolic characteristics of Grillo wines produced by a selected winery from 2011 to 2021 using an optimized RP-HPLC-DAD method. The results showed the presence of three clusters in the samples, representing different vintages. Polyphenols were identified as suitable markers for identifying Grillo vintages and could be related to storage conditions and production processes.
Review
Physiology
Huige Li, Ning Xia
Summary: Alcohol consumption has a complex relationship with cardiovascular risk, with heavy use and binge drinking harming cardiovascular health, while the effect of light-to-moderate alcohol consumption remains controversial. The type of alcoholic beverage consumed can also have varying effects on cardiovascular health, such as increasing HDL cholesterol and adiponectin levels, and reducing fibrinogen levels.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Carla Petrella, Maria Grazia Di Certo, Francesca Gabanella, Christian Barbato, Flavio Maria Ceci, Antonio Greco, Massimo Ralli, Antonella Polimeni, Antonio Angeloni, Cinzia Severini, Mario Vitali, Giampiero Ferraguti, Mauro Ceccanti, Marco Lucarelli, Carola Severi, Marco Fiore
Summary: The Mediterranean diet, known for its intake of foods rich in antioxidants and polyphenols like olives and extra virgin olive oil, as well as resveratrol, shows beneficial properties for human health. These polyphenols could potentially be used in pharmaceutical formulations for disease treatment and have emerging importance in the prevention and management of neurodegenerative and neuromuscular disorders.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Susana Ferreyra, Ruben Bottini, Ariel Fontana
Summary: This study investigates the stability of PCs in grape canes extracts under different storage temperatures and light conditions. The composition of PCs was analyzed every two weeks using LC-DAD-FLD. Stilbenes initially accounted for 87% of total PCs. Storage at -20 and 5 degrees C resulted in a reduction of 8% and 6% in PCs, respectively. Higher temperatures and light exposure accelerated the degradation of certain PCs, such as (+)-catechin and (-)-epicatechin. trans-piceatannol was particularly sensitive to temperature increase, while the degradation of trans-resveratrol and epsilon-viniferin was mostly catalyzed by light.
Article
Nutrition & Dietetics
Teresa Louro, Carla Simoes, Maria Joao Penetra, Laura Carreira, Paula Midori Castelo, Henrique Luis, Pedro Moreira, Elsa Lamy
Summary: The study found a relationship between adherence to the Mediterranean Diet and saliva protein composition, depending on individuals' Body Mass Index (BMI). Polyphenol intake was positively associated with S-type cystatins levels, particularly when flavanols were considered separately. Results suggest that normal weight and overweight individuals may have different salivary responses to diet.
Review
Nutrition & Dietetics
Paula Silva, Maria Rodriguez-Perez, Oscar Gomez-Torres, Emma Burgos-Ramos
Summary: This study reviews the protective effect of polyphenolic compounds from extra virgin olive oil and wine in Alzheimer's disease (AD) and emphasizes that they could be potential therapeutic tools. Polyphenols have beneficial effects in beta-aggregation, neurofibrillary tangles, autophagy, mitochondrial function, and cerebral insulin resistance. Additionally, no harmful dose has been identified.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Microbiology
Carla Zannella, Annalisa Chianese, Giuseppe Annunziata, Annalisa Ambrosino, Anna De Filippis, Gian Carlo Tenore, Ettore Novellino, Mariano Stornaiuolo, Massimiliano Galdiero
Summary: Herpes simplex virus (HSV) is a common virus that causes oral or genital ulcers and can lead to severe complications. Current anti-HSV drugs have limitations, so there is a need for new antiviral compounds. This study tested a polyphenol-based nutraceutical formulation called Taurisolo(R), which showed potential in inhibiting the early stages of HSV-1 and HSV-2 infection. These findings suggest that Taurisolo(R) could be used as a topical treatment for preventing and healing herpes lesions.
Review
Nutrition & Dietetics
Katherina V. Gantenbein, Christina Kanaka-Gantenbein
Summary: Healthy nutrition, especially the Mediterranean diet, rich in anti-inflammatory and antioxidant components, helps reduce the incidence of obesity, diabetes, and other non-communicable diseases. The MD not only benefits physical health but also improves reproductive health, reduces the risk of neurodegenerative diseases, and provides protection against mental health issues.
Review
Nutrition & Dietetics
Samuel R. Weaver, Catarina Rendeiro, Helen M. McGettrick, Andrew Philp, Samuel J. E. Lucas
Summary: Red wine polyphenols (RWP) have shown significant improvements in blood pressure and vascular health in both animal and human studies. However, the benefits are more prominent in animal models compared to human populations.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Aline Yammine, Amira Namsi, Dominique Vervandier-Fasseur, John J. Mackrill, Gerard Lizard, Norbert Latruffe
Summary: The Mediterranean diet, rich in polyphenols, plays a crucial role in preventing various diseases, especially colorectal cancer. Selected dietary phytophenols can benefit health by increasing polyphenol metabolites and influencing the microbiome. The emergence of polyphenol formulations may enhance the effectiveness of the Mediterranean diet in cancer prevention.
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Dario Tuccinardi, Eleonora Moriconi, Laura Di Renzo, Giovanna Muscogiuri, Annamaria Colao, Silvia Savastano
Summary: Cancer cells predominantly utilize aerobic glycolysis for metabolism. This characteristic has led to the hypothesis that dietary manipulation, such as a ketogenic diet, can influence tumor treatment and prognosis. The effectiveness of the ketogenic diet in cancer management may be attributed to various mechanisms, beyond the originally proposed glucose/insulin signaling inhibition. A qualified nutritionist is essential in managing the potential complications of this dietary therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Paola Gualtieri, Marco Marchetti, Laura Di Renzo, Gemma Lou De Santis, Roselisa Palma, Carmela Colica, Giulia Frank, Antonino De Lorenzo, Nicola Di Lorenzo
Summary: Obese patients with COVID-19 face worse outcomes due to prothrombotic and low-grade inflammation status. The postponement of bariatric surgery during the SARS-CoV-2 outbreak has caused delays in obesity treatment and severe consequences. This umbrella review highlights the need to prioritize bariatric surgery as obesity is a risk factor for severe COVID-19 and the economic costs of the pandemic are substantial.
Article
Nutrition & Dietetics
Paola Gualtieri, Marco Marchetti, Giulia Frank, Rossella Cianci, Giulia Bigioni, Carmela Colica, Laura Soldati, Alessandra Moia, Antonino De Lorenzo, Laura Di Renzo
Summary: This study aimed to investigate the adherence to the Mediterranean diet and its impact on health, environmental sustainability, and socioeconomic factors during the COVID-19 pandemic in Italy. The study found that adherence to the Mediterranean diet affected carbon and water footprints as well as food expenditure. The results showed that individuals with lower and medium adherence to the Mediterranean diet had higher carbon and water footprints. There were also significant differences in food expenditure among different levels of adherence to the Mediterranean diet.
Article
Genetics & Heredity
Paola Gualtieri, Marco Marchetti, Giulia Frank, Antonella Smeriglio, Domenico Trombetta, Carmela Colica, Rossella Cianci, Antonino De Lorenzo, Laura Di Renzo
Summary: The Mediterranean Diet is associated with beneficial effects against chronic non-communicable diseases. A study on 24 subjects showed that 2-week supplementation with mixed apple and bergamot juice had a positive impact on body composition, biochemical profile, and oxidative and inflammatory gene expression. The supplementation resulted in increased lean mass, reduced total cholesterol/HDL index, and improved gene expression related to CNCDs.
Article
Nutrition & Dietetics
Paola Gualtieri, Domenico Trombetta, Antonella Smeriglio, Giulia Frank, Angela Alibrandi, Giulia Leggeri, Marco Marchetti, Ilaria Zingale, Silvia Fanelli, Arianna Stocchi, Laura Di Renzo
Summary: Supplementation has a positive impact on vaccination response, enhancing immune defenses and reducing side effects. Our study analyzed the relationship between vaccine side effects and supplement intake among the Italian population. The results showed a significant correlation between supplement consumption and side effects at the end of the vaccination cycle, as well as associations with specific side effects such as diarrhea and nausea.
Editorial Material
Nutrition & Dietetics
Laura Di Renzo, Paola Gualtieri, Giulia Frank, Antonino De Lorenzo
Article
Pharmacology & Pharmacy
Laura Di Renzo, Antonella Smeriglio, Mariarosaria Ingegneri, Paola Gualtieri, Domenico Trombetta
Summary: Current evidence supports the use of EVOO and its minor components to improve cardiovascular and metabolic health. This study investigated the pharmacokinetics of DOPET, a bioactive compound in EVOO, on 20 healthy volunteers. Results showed higher bioavailability of DOPET compared to literature, suggesting the role of pharmaceutical formulation in its bioavailability and pharmacokinetics.
Review
Nutrition & Dietetics
Paola Gualtieri, Rossella Cianci, Giulia Frank, Erica Pizzocaro, Gemma Lou De Santis, Silvia Giannattasio, Giuseppe Merra, Giovanni Butturini, Antonino De Lorenzo, Laura Di Renzo
Summary: The incidence of pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is increasing worldwide and is associated with chronic inflammation. Imbalance in the gut microbiota composition, known as dysbiosis, can lead to chronic inflammation and potentially promote PDAC development. Nutrition plays a modulatory role in the immunological processes of PDAC, influencing the gut microbiota composition and inflammation levels, thereby affecting the pathogenesis and progression of PDAC.
Article
Nutrition & Dietetics
Laura Di Renzo, Paola Gualtieri, Samanta Zomparelli, Gemma Lou De Santis, Silvia Seraceno, Claudia Zuena, Giulia Frank, Rossella Cianci, Domenico Centofanti, Antonino De Lorenzo, Rita Businaro
Summary: This study evaluated the use of a modified Mediterranean ketogenic diet (MMKD) combined with carboxytherapy as a treatment for lipedema patients. The results showed that the ketogenic diet effectively induced weight and fat loss, including in the limbs. However, the best results were obtained from the combination of the ketogenic diet and carboxytherapy, which showed improvements in body composition, skin texture, pain reduction, and sleep quality.
Article
Nutrition & Dietetics
Giulia Cinelli, Ileana Croci, Gemma Lou De Santis, Ilenia Chianello, Kiersten Pilar Miller, Paola Gualtieri, Laura Di Renzo, Antonino De Lorenzo, Alberto Eugenio Tozzi, Valeria Zanna
Summary: This observational pilot study suggests that adherence to the Mediterranean Diet may contribute to weight and functional recovery in outpatient adolescents with Anorexia Nervosa. Patients who followed the Mediterranean Diet showed increased weight, lean body mass, and improved resting energy expenditure.
Review
Nutrition & Dietetics
Valentina Tassinari, Antonella Smeriglio, Virgilio Stillittano, Domenico Trombetta, Romano Zilli, Roberta Tassinari, Francesca Maranghi, Giulia Frank, Daniele Marcoccia, Laura Di Renzo
Summary: Endometriosis is a chronic inflammatory disease that is estrogen-dependent and characterized by the presence of extrauterine endometrial tissue, causing pelvic pain and fertility impairment. The exact cause of endometriosis is not fully understood, and conventional therapies have shown effectiveness but with considerable side effects. There is a growing interest in the use of herbal medicine for endometriosis treatment, particularly polyphenols that have anti-endometriotic and anti-inflammatory properties. This review aims to provide an overview of the anti-inflammatory activity of polyphenols in the treatment of endometriosis.
Article
Genetics & Heredity
Laura Di Renzo, Paola Gualtieri, Giulia Frank, Gemma Lou De Santis, Rossella Cianci, Giulia Bigioni, Antonino De Lorenzo
Summary: The study aims to assess the effects of Mediterranean diet on healthy volunteers and found that sex differences impact the treatment response and genetic expression related to oxidative stress. These findings may contribute to personalized diet therapy and overall health and well-being.
Review
Health Care Sciences & Services
Marika De Vito, Sara Alameddine, Giulia Capannolo, Ilenia Mappa, Paola Gualtieri, Laura Di Renzo, Antonino De Lorenzo, Francesco D'Antonio, Giuseppe Rizzo
Summary: This study reports on the quality and clinical heterogeneity of published clinical practice guidelines on nutrition in pregnancy. There is substantial variation in recommendations for vitamins, folic acid, and micronutrient intake during pregnancy. While the overall methodology is good, there is still significant heterogeneity in various aspects of nutrition recommendations.
