Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma

(2022) Janice M. Mehnert et al.   CLINICAL CANCER RESEARCH

Built to last: lysosome remodeling and repair in health and disease

(2022) Roberto Zoncu et al.   TRENDS IN CELL BIOLOGY

First-in-human effects of PPT1 inhibition using the oral treatment with GNS561/ Ezurpimtrostat in patients with primary and secondary liver cancers

(2022) James J. Harding et al.   Liver Cancer

Binding of hydroxychloroquine and chloroquine dimers to palmitoyl-protein thioesterase 1 (PPT1) and its glycosylated forms: a computational approach

(2021) Gérard Vergoten et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy

(2021) Christina G. Towers et al.   DEVELOPMENTAL CELL

A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis

(2021) Brianna M. Quinville et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma

(2021) Romain Riscal et al.   Cancer Discovery

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

(2021) Sonia Brun et al.   Autophagy

Lipid Rafts: Controversies Resolved, Mysteries Remain

(2020) Ilya Levental et al.   TRENDS IN CELL BIOLOGY

Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses

(2020) Patricia Dubot et al.   Cancers

A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

(2020) Herbert J. Zeh et al.   CLINICAL CANCER RESEARCH

Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

(2020) Gretchen M. Alicea et al.   Cancer Discovery

Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

(2020) Jody Vykoukal et al.   Nature Communications

Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections

(2020) Franziska Schmidt et al.   Cell Reports

Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells

(2019) Alexander Agrotis et al.   Autophagy

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer

(2019) Thomas B. Karasic et al.   JAMA Oncology

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

(2019) Christina G. Towers et al.   DEVELOPMENTAL CELL

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux

(2018) Wen-Jun Shen et al.   Annual Review of Physiology

Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients With Melanoma Treated With Pembrolizumab

(2018) Richard W. Joseph et al.   CLINICAL CANCER RESEARCH

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor

(2018) Peter M. Grin et al.   Scientific Reports

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

(2018) Andrew P. Morris et al.   Nature Communications

PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.

(2018) Vito W Rebecca et al.   Cancer Discovery

ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma

(2018) Rani Ojha et al.   Cancer Discovery

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Combenefit: an interactive platform for the analysis and visualization of drug combinations

(2016) Giovanni Y. Di Veroli et al.   BIOINFORMATICS

Ca2+-regulated lysosome fusion mediates angiotensin II-induced lipid raft clustering in mesenteric endothelial cells

(2016) Wei-Qing Han et al.   HYPERTENSION RESEARCH

The Primary Effect on the Proteome ofARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level

(2016) Aaron R. Goldman et al.   MOLECULAR & CELLULAR PROTEOMICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Long-term outcome in BRAFV600E melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression

(2015) Igor Puzanov et al.   EUROPEAN JOURNAL OF CANCER

The Assembly of GM1 Glycolipid- and Cholesterol-Enriched Raft-Like Membrane Microdomains Is Important for Giardial Encystation

(2015) Atasi De Chatterjee et al.   INFECTION AND IMMUNITY

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

(2015) Lunawati Bennett et al.   Drug Design Development and Therapy

Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy

(2015) Helena Cirenajwis et al.   Oncotarget

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells

(2012) Takayuki Sassa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Inhibitors of specific ceramide synthases

(2011) Susanne Schiffmann et al.   BIOCHIMIE

Functional Aspects of Membrane Association of Reggie/Flotillin Proteins

(2011) Antje Banning et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Systematic Discovery of Ectopic Pregnancy Serum Biomarkers Using 3-D Protein Profiling Coupled with Label-free Quantitation

(2010) Lynn A. Beer et al.   JOURNAL OF PROTEOME RESEARCH

Increased Hepatic Insulin Action in Diet-Induced Obese Mice Following Inhibition of Glucosylceramide Synthase

(2010) Nelson S. Yew et al.   PLoS One

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity†,‡,§

(2007) Thomas J. F. Nieland et al.   BIOCHEMISTRY