DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Upregulated Seizure-Related 6 Homolog-Like 2 Is a Prognostic Predictor of Hepatocellular Carcinoma

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Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

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Improved detection of differentially represented DNA barcodes for high‐throughput clonal phenomics

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Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

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CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade

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Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial

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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

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DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

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Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

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Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

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The hallmarks of successful anticancer immunotherapy

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Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

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Evolution of Metastases in Space and Time under Immune Selection

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Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

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Identification of essential genes for cancer immunotherapy

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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

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Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

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No counts, no variance: allowing for loss of degrees of freedom when assessing biological variability from RNA-seq data

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Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis

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Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer

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Combining Epigenetic and Immunotherapy to Combat Cancer

(2016) Katherine B. Chiappinelli et al.   CANCER RESEARCH

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

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Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study

(2016) H. Raza Ali et al.   PLOS MEDICINE

Relevance of tumor-infiltrating lymphocytes in breast cancer

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A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

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Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

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Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic Progression

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Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface-Associated GRP78

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An optimized method for establishing high purity murine CD8+ T cell cultures

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Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

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Comprehensive molecular portraits of human breast tumours

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

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cn.MOPS: mixture of Poissons for discovering copy number variations in next-generation sequencing data with a low false discovery rate

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Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

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Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

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An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

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