Rational hemostatic management in cirrhosis: from old paradigms to new clinical challenges

Viscoelastic Testing Prior to Non-surgical Procedures Reduces Blood Product Use Without Increasing Bleeding Risk in Cirrhosis

(2022) Abhishek Shenoy et al.   DIGESTIVE DISEASES AND SCIENCES

Aspirin Use and Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B With or Without Cirrhosis

(2022) Heejoon Jang et al.   HEPATOLOGY

Haemostatic alterations in patients with cirrhosis and hepatocellular carcinoma: laboratory evidence and clinical implications

(2022) Alberto Zanetto et al.   LIVER INTERNATIONAL

Preprocedural prophylaxis with blood products in patients with cirrhosis: results from a survey of the Italian Association for the study of the Liver (AISF)

(2022) G. Tosetti et al.   DIGESTIVE AND LIVER DISEASE

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis

(2022) Erica Villa et al.   JOURNAL OF HEPATOLOGY

Increased platelet aggregation in patients with decompensated cirrhosis indicates higher risk of further decompensation and death.

(2022) Alberto Zanetto et al.   JOURNAL OF HEPATOLOGY

Association of aspirin and nonaspirin NSAIDs therapy with the incidence risk of hepatocellular carcinoma

(2021) Yuwei Liu et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Comparison of the Efficacy and Safety of Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation and Concomitant Liver Cirrhosis: A Systematic Review and Meta-Analysis

(2021) Zhi-Yan Lee et al.   American Journal of Cardiovascular Drugs

Fresh Frozen Plasma Transfusion in Acute Variceal Hemorrhage: Results from a Multicenter Cohort Study

(2021) Arpan Mohanty et al.   LIVER INTERNATIONAL

Safety and Efficacy of Direct Oral Anticoagulants in Patients With Moderate to Severe Cirrhosis

(2021) Mildred Oldham et al.   ANNALS OF PHARMACOTHERAPY

Safety of direct oral anticoagulants in patients with advanced liver disease

(2021) Georg Semmler et al.   LIVER INTERNATIONAL

Coagulopathy is not predictive of bleeding in patients with acute decompensation of cirrhosis and acute‐on‐chronic liver failure

(2021) Elena Campello et al.   LIVER INTERNATIONAL

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis

(2021) Alessandro Mantovani et al.   Lancet Gastroenterology & Hepatology

AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis

(2021) Robert S. O’Shea et al.   GASTROENTEROLOGY

Baveno VII – Renewing consensus in portal hypertension

(2021) Roberto de Franchis et al.   JOURNAL OF HEPATOLOGY

ACG Clinical Guideline

(2020) Douglas A. Simonetto et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality

(2020) Tracey G. Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rates of Bleeding and Discontinuation of Direct Oral Anticoagulants in Patients with Decompensated Cirrhosis

(2020) Joseph F. Mort et al.   Clinical Gastroenterology and Hepatology

Acute kidney injury in decompensated cirrhosis is associated with both hypo‐ and hyper‐coagulable features

(2020) Alberto Zanetto et al.   HEPATOLOGY

Hypercoagulability (thrombin generation) in patients with cirrhosis is detected with ST‐Genesia

(2020) Laurie Talon et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

(2020) Ian Roberts et al.   LANCET

Efficacy and Safety of Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Liver Disease: a Meta-Analysis and Systematic Review

(2020) Zhi-Chun Huang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Risk of incident bleeding after acute kidney injury: A retrospective cohort study

(2020) Farah Zarka et al.   JOURNAL OF CRITICAL CARE

Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases

(2020) Patrick G. Northup et al.   HEPATOLOGY

Decreased fibrinolytic capacity in cirrhosis and liver transplant outcomes

(2019) Ton Lisman   LIVER TRANSPLANTATION

Real-Time Ultrasound-Guided Paracentesis by Radiologists: Near Zero Risk of Hemorrhage without Correction of Coagulopathy

(2019) Michael W. Rowley et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Prediction of ticagrelor and its active metabolite in liver cirrhosis populations using a physiologically based pharmacokinetic model involving pharmacodynamics

(2019) Min Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L‐PLUS 2)

(2019) Markus Peck‐Radosavljevic et al.   HEPATOLOGY

Thromboelastography-guided Blood Product Transfusion in Cirrhosis Patients With Variceal Bleeding

(2019) Gyanranjan Rout et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Thromboelastography‐Guided Blood Component Use in Patients With Cirrhosis With Nonvariceal Bleeding: A Randomized Controlled Trial

(2019) Manoj Kumar et al.   HEPATOLOGY

Mixed fibrinolytic phenotypes in decompensated cirrhosis and ACLF with hypofibrinolysis in those with complications and poor survival

(2019) Annabel Blasi et al.   HEPATOLOGY

Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions—Part II: Recommendations

(2019) Indravadan J. Patel et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

A Randomized Control Trial of Thromboelastography-Guided Transfusion in Cirrhosis for High-Risk Invasive Liver-Related Procedures

(2019) Sudheer K Vuyyuru et al.   DIGESTIVE DISEASES AND SCIENCES

Thromboelastography versus standard coagulation testing in the assessment and reversal of coagulopathy among cirrhotics

(2019) Alexander J. Kovalic et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Dual antiplatelet therapy in patients with cirrhosis and acute myocardial infarction – A 13-year nationwide cohort study

(2019) Victor Chien-Chia Wu et al.   PLoS One

Clopidogrel Responsiveness in Patients With Decompensated Cirrhosis of the Liver Undergoing Pre-Transplant PCI

(2019) Cory R. Trankle et al.   JACC-Cardiovascular Interventions

Harmful and Beneficial Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis

(2018) Vincenzo La Mura et al.   Clinical Gastroenterology and Hepatology

Avatrombopag Before Procedures Reduces Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

(2018) Norah Terrault et al.   GASTROENTEROLOGY

Coagulation failure in patients with Acute-on-Chronic Liver Failure (ACLF) and decompensated cirrhosis: beyond INR

(2018) Annabel Blasi et al.   HEPATOLOGY

Trends in Red Blood Cell, Plasma, and Platelet Transfusions in the United States, 1993-2014

(2018) Ruchika Goel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure

(2018) Caleb Fisher et al.   JOURNAL OF CRITICAL CARE

In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis

(2018) Ton Lisman et al.   LIVER INTERNATIONAL

Acute kidney injury, but not sepsis, is associated with higher procedure-related bleeding in patients with decompensated cirrhosis

(2018) Adelina Hung et al.   LIVER INTERNATIONAL

Utilization of Aspirin and Statin in Management of Coronary Artery Disease in Patients with Cirrhosis Undergoing Liver Transplant Evaluation

(2018) Samarth S. Patel et al.   LIVER TRANSPLANTATION

Hemorrhagic Shock

(2018) Jeremy W. Cannon   NEW ENGLAND JOURNAL OF MEDICINE

Direct oral anticoagulants and cirrhosis: More evidence still needed for efficacy and safety in portal vein thrombosis

(2018) Pier Mannuccio Mannucci et al.   VASCULAR PHARMACOLOGY

Coagulation, Microenvironment and Liver Fibrosis

(2018) Niccolò Bitto et al.   Cells

Efficacy and safety of anticoagulation for atrial fibrillation in patients with cirrhosis: A systematic review and meta-analysis

(2018) Ronpichai Chokesuwattanaskul et al.   DIGESTIVE AND LIVER DISEASE

Epidemiology of atrial fibrillation in patients with cirrhosis and clinical significance

(2018) Ronpichai Chokesuwattanaskul et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Association Between Aspirin Use and Risk of Hepatocellular Carcinoma

(2018) Tracey G. Simon et al.   JAMA Oncology

Management of severe perioperative bleeding

(2017) Sibylle A. Kozek-Langenecker et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

The efficacy and safety of direct oral anticoagulants vs traditional anticoagulants in cirrhosis

(2017) Justine Hum et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis

(2017) Lorenzo Loffredo et al.   GASTROENTEROLOGY

Thromboelastography and blood product usage in cirrhosis with severe coagulopathy

(2017) Antoni Sabate et al.   HEPATOLOGY

K time & maximum amplitude of thromboelastogram predict post-central venous cannulation bleeding in patients with cirrhosis: A pilot study

(2017) ChandraK Pandey et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Gut-derived endotoxin stimulates factor VIII secretion from endothelial cells. Implications for hypercoagulability in cirrhosis

(2017) Roberto Carnevale et al.   JOURNAL OF HEPATOLOGY

DIC in decompensated cirrhosis caused by prothrombin complex concentrate and recombinant activated factor VII: A word of caution

(2017) Jason P. Glass et al.   LIVER INTERNATIONAL

Cirrhosis is a risk factor for atrial fibrillation: A nationwide, population-based study

(2017) HyunJung Lee et al.   LIVER INTERNATIONAL

Evaluation of coronary artery disease in potential liver transplant recipients

(2017) Brian J. Hogan et al.   LIVER TRANSPLANTATION

Reversal of direct oral anticoagulants for liver transplantation in cirrhosis: A step forward

(2017) Nicolas M. Intagliata et al.   LIVER TRANSPLANTATION

The risk of venous thromboembolism in patients with cirrhosis

(2017) Pasquale Ambrosino et al.   THROMBOSIS AND HAEMOSTASIS

Management of Hemostatic Disorders in Patients With Advanced Liver Disease Admitted to an Intensive Care Unit

(2017) Ton Lisman et al.   TRANSFUSION MEDICINE REVIEWS

Liver Cirrhosis in Patients With Atrial Fibrillation: Would Oral Anticoagulation Have a Net Clinical Benefit for Stroke Prevention?

(2017) Ling Kuo et al.   Journal of the American Heart Association

Changing Concepts of Cirrhotic Coagulopathy

(2016) Armando Tripodi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Rotation thromboelastometry velocity curve predicts blood loss during liver transplantation

(2016) L.A. Tafur et al.   BRITISH JOURNAL OF ANAESTHESIA

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

(2016) Angelo Andriulli et al.   DIGESTIVE AND LIVER DISEASE

Coagulation parameters and major bleeding in critically ill patients with cirrhosis

(2016) Andreas Drolz et al.   HEPATOLOGY

Low-grade endotoxemia and platelet activation in cirrhosis

(2016) Valeria Raparelli et al.   HEPATOLOGY

EASL Clinical Practice Guidelines: Vascular diseases of the liver

(2016)   JOURNAL OF HEPATOLOGY

Management of the critically ill patient with cirrhosis: A multidisciplinary perspective

(2016) Mitra K. Nadim et al.   JOURNAL OF HEPATOLOGY

von Willebrand factor and procoagulant imbalance predict outcome in patients with cirrhosis and thrombocytopenia

(2016) Georgios N. Kalambokis et al.   JOURNAL OF HEPATOLOGY

The past and future of haemophilia: diagnosis, treatments, and its complications

(2016) Flora Peyvandi et al.   LANCET

Rotational thromboelastometry can detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis

(2016) Sotiria Bedreli et al.   LIVER INTERNATIONAL

Thrombocytopenia in chronic liver disease

(2016) Markus Peck-Radosavljevic   LIVER INTERNATIONAL

Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis

(2016) Andrea De Gottardi et al.   LIVER INTERNATIONAL

Resistance to thrombomodulin is associated withde novoportal vein thrombosis and low survival in patients with cirrhosis

(2016) Vincenzo La Mura et al.   LIVER INTERNATIONAL

Platelet Function Tests

(2016) Marie Lordkipanidzé   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Survival after splanchnic vein thrombosis: A 20-year nationwide cohort study

(2016) Kirstine Kobberøe Søgaard et al.   THROMBOSIS RESEARCH

Impact of Vitamin K Administration on INR Changes and Bleeding Events Among Patients With Cirrhosis

(2015) Adam V. Meyer et al.   ANNALS OF PHARMACOTHERAPY

Anticoagulation for the treatment of portal vein thrombosis in liver cirrhosis: A systematic review and meta-analysis of observational studies

(2015) Xingshun Qi et al.   European Journal of Internal Medicine

Impact of anticoagulation on upper-gastrointestinal bleeding in cirrhosis. A retrospective multicenter study

(2015) Federica Cerini et al.   HEPATOLOGY

Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial

(2015) Lesley De Pietri et al.   HEPATOLOGY

Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study

(2015) Filipe Nery et al.   HEPATOLOGY

Bleeding Rate for Ultrasound-Guided Paracentesis in Thrombocytopenic Patients

(2015) A. Nicholas Kurup et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Patterns of blood component use in cirrhosis: a nationwide study

(2015) Michael J. R. Desborough et al.   LIVER INTERNATIONAL

Hemorrhagic Complications Following Abdominal Paracentesis in Acute on Chronic Liver Failure

(2015) Su Lin et al.   MEDICINE

Investigation of platelet function and platelet disorders using flow cytometry

(2015) Peter Rubak et al.   PLATELETS

Incidence and risk factors of delayed postpolypectomy bleeding in patients with chronic liver disease

(2015) Hee Seung Lee et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The Fibrinolytic Status in Liver Diseases

(2015) Dingeman Rijken et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Portal vein thrombosis in cirrhosis: Controversies and latest developments

(2015) Damian J Harding et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Major complications due to transjugular liver biopsy: Incidence, management and outcome

(2015) A. Dohan et al.   Diagnostic and Interventional Imaging

Prevalence and Prediction of Coronary Artery Disease in Patients With Liver Cirrhosis

(2014) Jihyun An et al.   CIRCULATION

Correction of hemostatic abnormalities and portal pressure variations in patients with cirrhosis

(2014) Edoardo G. Giannini et al.   HEPATOLOGY

Transfusion of fresh-frozen plasma in critically ill patients with a coagulopathy before invasive procedures: a randomized clinical trial (CME)

(2014) Marcella C. Müller et al.   TRANSFUSION

Hemostasis in Liver Disease: Implications of New Concepts for Perioperative Management

(2014) Pepijn D. Weeder et al.   TRANSFUSION MEDICINE REVIEWS

TEG and ROTEM: Technology and clinical applications

(2013) David Whiting et al.   AMERICAN JOURNAL OF HEMATOLOGY

Frequency of and Risk Factors for Complications After Liver Radiofrequency Ablation Under CT Fluoroscopic Guidance in 1500 Sessions: Single-Center Experience

(2013) Haruyuki Takaki et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Coronary artery disease and its risk factors in patients presenting for liver transplantation

(2013) Edward Gologorsky et al.   JOURNAL OF CLINICAL ANESTHESIA

Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis

(2013) Armando Tripodi et al.   JOURNAL OF HEPATOLOGY

Transfusion Strategies for Acute Upper Gastrointestinal Bleeding

(2013) Càndid Villanueva et al.   NEW ENGLAND JOURNAL OF MEDICINE

The coagulopathy of liver disease

(2012) Maha F. Saja et al.   BLOOD COAGULATION & FIBRINOLYSIS

Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis

(2012) María Gabriela Delgado et al.   Clinical Gastroenterology and Hepatology

Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis

(2012) Erica Villa et al.   GASTROENTEROLOGY

Hypoxic Hepatitis Occurring in Cirrhosis After Variceal Bleeding

(2012) Lucio Amitrano et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Postoperative Bleeding After Dental Extraction in Liver Pretransplant Patients

(2012) João Paulo Veloso Perdigão et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion

(2012) Armando Tripodi et al.   LIVER INTERNATIONAL

Eltrombopag before Procedures in Patients with Cirrhosis and Thrombocytopenia

(2012) Nezam H. Afdhal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness and safety of antiplatelet therapy in stroke recurrence prevention in patients with liver cirrhosis: a 2-year follow-up study

(2012) Chung-Yu Chen et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials (CME)

(2012) Lucy Yang et al.   TRANSFUSION

Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies

(2012) B. Hutton et al.   BMJ-British Medical Journal

Comparison of the Frequency of Coronary Artery Disease in Alcohol-Related Versus Non-Alcohol-Related Endstage Liver Disease

(2011) Sanjay Patel et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effectiveness of Combined Pharmacologic and Ligation Therapy in High-Risk Patients With Acute Esophageal Variceal Bleeding

(2011) Salvador Augustin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension

(2011) V. La Mura et al.   GUT

Coronary Artery Stents and Antiplatelet Therapy in Patients With Cirrhosis

(2011) Mark W. Russo et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?

(2011) F. Violi et al.   JOURNAL OF HEPATOLOGY

Hypercoagulability in cirrhosis: causes and consequences1

(2011) A. TRIPODI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Coagulopathy of Chronic Liver Disease

(2011) Armando Tripodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombin generation tests

(2011) Elisabetta Castoldi et al.   THROMBOSIS RESEARCH

Complication Rate of Percutaneous Liver Biopsies Among Persons With Advanced Chronic Liver Disease in the HALT-C Trial

(2010) Leonard B. Seeff et al.   Clinical Gastroenterology and Hepatology

Liver Cirrhosis Is Associated With Venous Thromboembolism Among Hospitalized Patients in a Nationwide US Study

(2010) Harry Wu et al.   Clinical Gastroenterology and Hepatology

Safety and Efficacy of Anticoagulation Therapy With Low Molecular Weight Heparin for Portal Vein Thrombosis in Patients With Liver Cirrhosis

(2010) Lucio Amitrano et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Systematic review: portal vein thrombosis in cirrhosis

(2009) E. A. TSOCHATZIS et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

An Imbalance of Pro- vs Anti-Coagulation Factors in Plasma From Patients With Cirrhosis

(2009) Armando Tripodi et al.   GASTROENTEROLOGY

Portal vein thrombosis and survival in patients with cirrhosis

(2009) Michael J. Englesbe et al.   LIVER TRANSPLANTATION

Thrombopoietin and Thrombopoietin Mimetics in the Treatment of Thrombocytopenia

(2008) David J. Kuter   Annual Review of Medicine

Thrombin generation testing in routine clinical practice: are we there yet?

(2008) J. J. van Veen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: A randomized, controlled trial

(2008) Jaime Bosch et al.   HEPATOLOGY

A Comparison of Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery

(2008) Dean A. Fergusson et al.   NEW ENGLAND JOURNAL OF MEDICINE