Journal
CELL BIOCHEMISTRY AND FUNCTION
Volume 33, Issue 4, Pages 220-225Publisher
WILEY
DOI: 10.1002/cbf.3107
Keywords
euphorbiasteroid; obesity; adipogenesis; AMPK; 3T3-L1
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Funding
- Korea Food Research Institute, Republic of Korea
- KU Brain Pool of Konkuk University, Seoul, Korea
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The purpose of this study is to investigate the effects of euphorbiasteroid, a component of Euphorbia lathyris L., on adipogenesis of 3T3-L1 pre-adipocytes and its underlying mechanisms. Euphorbiasteroid decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation at concentrations of 25 and 50M. In addition, euphorbiasteroid altered the key regulator proteins of adipogenesis in the early stage of adipocyte differentiation by increasing the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase. Subsequently, levels of adipogenic proteins, including fatty acid synthase, peroxisome proliferator-activated receptor- and CCAAT/enhancer-binding protein , were decreased by euphorbiasteroid treatment at the late stage of adipocyte differentiation. The anti-adipogenic effect of euphorbiasteroid may be derived from inhibition of early stage of adipocyte differentiation. Taken together, euphorbiasteroid inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway. Therefore, euphorbiasteroid and its source plant, E.lathyris L., could possibly be one of the fascinating anti-obesity agent. Copyright (c) 2015 John Wiley & Sons, Ltd.
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