Article
Pharmacology & Pharmacy
Ibrahim Bulama, Suleiman Nasiru, Abubakar Bello, Abdullahi Yahaya Abbas, Jinjiri Ismail Nasiru, Yusuf Saidu, Musa Samaila Chiroma, Mohamad Aris Mohd Moklas, Che Norma Mat Taib, Ali Waziri, Bilbis Lawal Suleman
Summary: This study evaluated the antioxidative neuroprotective property and learning and memory-enhancing effects of dimethyl sulfoxide (DMSO) in a rat model after traumatic brain injury (TBI). The results showed that DMSO improved learning and memory, locomotor function, and decreased anxiety in rats with induced TBI. Additionally, DMSO decreased oxidative stress and S100B levels, while increasing the activity of antioxidant enzymes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Pinar Kuru Bektasoglu, Dilan Demir, Turkan Koyuncuoglu, Meral Yuksel, Irem Peker Eyuboglu, Ayca Karagoz Koroglu, Dilek Akakin, Alper Yildirim, Erhan Celikoglu, Bora Gurer
Summary: The study suggests that treatment with apigenin may have neuroprotective effects in mild traumatic brain injury by decreasing the levels of luminol and lucigenin and increasing the levels of the anti-inflammatory cytokine IL-10. Additionally, treatment with apigenin at a dosage of 20 mg/kg improved trauma-induced cortical tissue damage.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Critical Care Medicine
Pinar Kuru Bektasoglu, Turkan Koyuncuoglu, Dilan Ozaydin, Cansu Kandemir, Dilek Akakin, Meral Yuksel, Bora Gurer, Erhan Celikoglu, Berrak C. Yegen
Summary: This study aimed to investigate the antioxidant and neuroprotective effects of Dexpanthenol in traumatic brain injury (TBI). The results showed that Dexpanthenol reduced oxidative damage, suppressed apoptosis by stimulating antioxidant systems, and alleviated brain damage caused by TBI.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Cell Biology
Pinar Kuru Bektasoglu, Turkan Koyuncuoglu, Selin Akbulut, Dilek Akakin, Irem Peker Eyuboglu, Can Erzik, Meral Yuksel, Hizir Kurtel
Summary: PAI-1 antagonists, especially TM5441, demonstrated antioxidant and anti-inflammatory properties against mild TBI in the acute period, improving behavioral test results after treatment. This study investigated the protective effects of PAI-1 antagonists in a rat mild TBI model, showing significant potential for neuroprotection.
Article
Immunology
Zhongyu Wang, Zhaoyang Wang, Anqi Wang, Juan Li, Junmin Wang, Jingjing Yuan, Xin Wei, Fei Xing, Wei Zhang, Na Xing
Summary: This study aimed to investigate the mechanism of Sevo in TBI by downregulating HES1 via the FGF2/EZH2 axis. Results showed that Sevo reduced brain edema, improved neurological scores, and decreased neuronal apoptosis and autophagy in TBI rats. Upregulation of FGF2 by Sevo preconditioning increased EZH2 expression, leading to downregulation of HES1 in TBI rats.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Behavioral Sciences
Nicholas S. Race, Katharine D. Andrews, Elizabeth A. Lungwitz, Sasha M. Vega Alvarez, Timothy R. Warner, Glen Acosta, Jiayue Cao, Kun-han Lu, Zhongming Liu, Amy D. Dietrich, Sreeparna Majumdar, Anantha Shekhar, William A. Truitt, Riyi Shi
Summary: TBI is associated with increased risk for mental health disorders, and deficits in psychosocial processing may contribute to post-TBI mental health issues. A pre-clinical investigation using rats found that a single mild blast TBI induced impairment of psychosocial processing in the absence of other confounding factors, and this impairment may be related to acute upregulations of an oxidative stress metabolite.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chidozie C. Anyaegbu, Harrison Szemray, Sarah C. Hellewell, Nathan G. Lawler, Kerry Leggett, Carole Bartlett, Brittney Lins, Terence McGonigle, Melissa Papini, Ryan S. Anderton, Luke Whiley, Melinda Fitzgerald
Summary: Mild traumatic brain injury (mTBI) can cause structural, cellular, and biochemical changes in the brain that are difficult to detect and may persist chronically. Lipidomic analysis of blood samples, which can easily cross the blood-brain barrier, may provide valuable insights into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to analyze plasma lipid concentrations after 11 days of sham, one (1 x), or two (2 x) mTBI in rats. They identified 18 lipid species that distinguished between different injury conditions and found that the changes in lipid concentrations varied depending on the number of mTBI, suggesting a balance of damage and reparative responses.
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Viktoriya V. Antonova, Denis N. Silachev, Ivan A. Ryzhkov, Konstantin N. Lapin, Sergey N. Kalabushev, Irina Ostrova, Lydia A. Varnakova, Oleg A. Grebenchikov
Summary: This study evaluated the therapeutic effects of a three-hour inhalation of argon after an open traumatic brain injury (TBI) in rats. The results showed that this treatment did not have a neuroprotective effect.
Article
Biochemistry & Molecular Biology
Ittetsu Kin, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Mihoko Okazaki, Kakeru Hosomoto, Yosuke Okazaki, Satoru Yabuno, Satoshi Kawauchi, Ken Kuwahara, Jun Morimoto, Kyohei Kin, Michiari Umakoshi, Yousuke Tomita, Naoki Tajiri, Cesario Borlongan, Isao Date
Summary: This study examined the efficacy of vagus nerve stimulation (VNS) on Parkinson's disease model rats using a wireless controllable electrical stimulator. The results showed that VNS with 0.25-0.5 mA intensity significantly improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. Further research confirmed the practicality and effectiveness of the new experimental device.
Article
Biology
Haruki Nishimura, Mitsuhiro Yoshimura, Makiko Shimizu, Kenya Sanada, Satomi Sonoda, Kazuaki Nishimura, Kazuhiko Baba, Naofumi Ikeda, Yasuhito Motojima, Takashi Maruyama, Yuki Nonaka, Ryoko Baba, Tatsushi Onaka, Takafumi Horishita, Hiroyuki Morimoto, Yasuhiro Yoshida, Makoto Kawasaki, Akinori Sakai, Masafumi Muratani, Becky Conway-Campbell, Stafford Lightman, Yoichi Ueta
Summary: The analgesic effect of oxytocin is mediated through its receptor and contributes to the anti-nociception and anti-inflammatory response. A transgenic rat line expressing hM3Dq and mCherry in oxytocin neurons was generated and demonstrated that oxytocin activates specific neurons and attenuates hyperalgesia. This analgesic effect is abolished by oxytocin receptor antagonist.
COMMUNICATIONS BIOLOGY
(2022)
Article
Behavioral Sciences
Chaolong Yan, Jiannan Mao, Chenbei Yao, Yang Liu, Huiying Yan, Wei Jin
Summary: The study found that mild hypothermia significantly improved neurobehavioral dysfunction and brain edema after TBI, enhanced antioxidant enzyme activity, reduced lipid peroxidation accumulation, upregulated the Nrf2-ARE pathway, and decreased cell apoptosis. These results suggest that the protective effects of mild hypothermia after TBI may be achieved through the Nrf2-ARE pathway, indicating Nrf2 as a potential target to improve TBI prognosis.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Pinar Kuru Bektasoglu, Turkan Koyuncuoglu, Dilan Demir, Gizem Sucu, Dilek Akakin, Irem Peker Eyuboglu, Meral Yuksel, Erhan Celikoglu, Berrak C. Yegen, Bora Gurer
Summary: In a rat model of TBI, cinnamaldehyde demonstrated neuroprotective effects by reducing neutrophil recruitment, suppressing reactive oxygen species, and decreasing histologic damage and acute hippocampal dysfunction.
WORLD NEUROSURGERY
(2021)
Article
Nanoscience & Nanotechnology
Jialin Huang, Han Zhu, Ping Yu, Yuxiao Ma, Jingru Gong, Yuli Fu, Huahua Song, Meng Huang, Jing Luo, Jiyao Jiang, Xiaoling Gao, Junfeng Feng, Gan Jiang
Summary: The combination of mild hypothermia and recombinant high-density lipoprotein (rHDL) can effectively improve the pathological and physiological manifestations of traumatic brain injury (TBI), and restore spatial learning and memory ability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Neurosciences
Fernando da Silva Fiorin, Caroline Cunha do Espirito Santo, Raphael Santos do Nascimento, Angela Patricia Franca, Luiz Fernando Freire Royes
Summary: This study provides a detailed characterization of the behavioral deficits induced by mild fluid percussion injury (FPI). The results show that mild FPI leads to a decrease in sweet liquid consumption, reduced social interaction time, and long-term memory deficits.
NEUROSCIENCE LETTERS
(2024)
