3.8 Article

Angiotensin-II blockage, muscle strength, and exercise capacity in physically independent older adults

Journal

JOURNAL OF PHYSICAL THERAPY SCIENCE
Volume 28, Issue 2, Pages 547-552

Publisher

SOC PHYSICAL THERAPY SCIENCE
DOI: 10.1589/jpts.28.547

Keywords

Ageing; Muscle strength; Exercise capacity

Categories

Funding

  1. CNPQ
  2. CAPES
  3. Fundacao Manoel de Barros

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[Purpose] This study aimed to assess the exercise capacity and muscle strength in elderly people using drugs for angiotensin-II blockage. [Subjects and Methods] Four hundred and seven older adults were recruited for this study. Data about comorbidities and medication use were recorded and the individuals were divided into three groups: control group-elderly people with normal exercise capacity (n=235); angiotensin-converting enzyme inhibitor group - individuals using angiotensin-converting enzyme inhibitors (n=140); and angiotensin-II receptor blocker group- patients using angiotensin-II receptor blockers (n=32). Exercise capacity was evaluated by a 6-minute walking test and muscle strength was measured using a handgrip dynamometer. [Results] Patients from the angiotensin-converting enzyme inhibitor group (mean: 99 +/- 12%) and the angiotensin-II receptor blocker group (mean: 101 +/- 14%) showed higher predicted values in the 6-minute walking test than the control group patients (mean: 96 +/- 10%). Patients from the angiotensin-converting enzyme inhibitor group (mean: 105 +/- 19%) and the angiotensin-II receptor blocker group (mean: 105.1 +/- 18.73%) showed higher predicted values of muscle strength than control group patients (mean: 98.15 +/- 18.77%). [Conclusion] Older adults using angiotensin-converting enzyme inhibitors or angiotensin-II receptor blockers have better functional exercise capacity and muscle strength.

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