Article
Multidisciplinary Sciences
Mohammad Reza Raveshi, Melati S. Abdul Halim, Sagar N. Agnihotri, Moira K. O'Bryan, Adrian Neild, Reza Nosrati
Summary: The curvature of the fallopian tube influences sperm motion, switching the mode of movement from faster surface alignment to prolonged interaction with the epithelium to enhance sperm maturation and fertilization competence. This dynamic switch in sperm motility was revealed using droplet microfluidics technology.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Amir M. Hajiyavand, Matthew J. Graham, Karl D. Dearn
Summary: This paper presents a novel algorithm for estimating the diameter of biological tubes with continuously changing cross-sections, providing more accurate results than manual measurements through evaluation using various controlled images.
Article
Oncology
Khalid El Bairi, Ouissam Al Jarroudi, Cecile Le Page, Said Afqir
Summary: Epithelial ovarian cancer is a heterogeneous disease mostly diagnosed in advanced stages, with high lethality, platinum-resistance, and poor survival outcomes. Recent progress has been made in understanding the origins of OC, particularly high-grade serous histology, challenging the long-standing belief of genetic alterations in ovarian cyst cells as the main driver of tumorigenesis. New evidence supports multiple extra-ovarian cell origins for different OC histotypes.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biophysics
Sai-Xi Yu, Yanan Liu, Yi Wu, Hao Luo, Rufei Huang, Ya-Jun Wang, Xuemei Wang, Hai Gao, Huijuan Shi, Guangyin Jing, Yan-Jun Liu
Summary: This study used hyaluronic acid as a substitute for cervical mucus and designed a cervix chip to study sperm selection and behavior. The results showed that hyaluronic acid can act as a filter to select active sperm.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Oncology
Angela Russo, Brian P. Cain, Tia Jackson-Bey, Alfredo Lopez Carrero, Jane Miglo, Shannon MacLaughlan, Brett C. Isenberg, Jonathan Coppeta, Joanna E. Burdette
Summary: In this study, it was found that testosterone promotes migration and invasion of human fallopian tube epithelial cells (FTSEC) by upregulating the WNT4 gene and downregulating p53 and its downstream target genes. Testosterone also enhances the adhesion of FTSEC to ovarian stroma. These findings highlight the importance of testosterone in the function of the human fallopian tube and provide a new strategy for studying migration in the presence of fluid flow.
Review
Reproductive Biology
Coline Mahe, Aleksandra Maria Zlotkowska, Karine Reynaud, Guillaume Tsikis, Pascal Mermillod, Xavier Druart, Jennifer Schoen, Marie Saint-Dizier
Summary: After mating or insemination, the region-specific and hormonally regulated morphology and secretions of the utero-tubal junction and oviduct lead to the selection of a limited sub-population of top quality spermatozoa at the site of fertilization.
BIOLOGY OF REPRODUCTION
(2021)
Article
Cell Biology
Qurat Ul Ain Reshi, Kasun Godakumara, James Ord, Keerthie Dissanayake, Mohammad Mehedi Hasan, Aneta Andronowska, Paul Heath, Alireza Fazeli
Summary: Spermatozoa can alter the gene expression in female reproductive tract epithelial cells both remotely and through contact, and can also change the cargo of extracellular vesicles derived from these cells, which may play an important role in pre and post-fertilization events.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Zoology
Maribel Mendez-Tepepa, Cuauhtemoc Morales-Cruz, Edelmira Garcia-Nieto, Arely Anaya-Hernandez
Summary: "Review on the Reproductive Biology of Frogs" aims to provide organized and specific information on frog reproduction. Schemes were developed for a clear understanding of the general reproductive mechanisms in frogs. The physiological, histological, and morphological mechanisms of each reproductive organ in male and female frogs were described. This manuscript contributes to a broader understanding of anuran reproductive biology by allowing comparisons with other amphibians.
ZOOLOGICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jesus Gonzalez-Bosquet, Nicholas D. D. Cardillo, Henry D. D. Reyes, Brian J. J. Smith, Kimberly K. K. Leslie, David P. P. Bender, Michael J. J. Goodheart, Eric J. J. Devor
Summary: Prediction models based on genomic variation can accurately discriminate high grade serous ovarian cancer from benign tissue. Further refining of these models has the potential to detect ovarian cancer in blood with cell free DNA, even in early stage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Nicole D. Ulrich, Yu-Chi Shen, Qianyi Ma, Kun Yang, D. Ford Hannum, Andrea Jones, Jordan Machlin, John F. Randolph, Yolanda R. Smith, Samantha B. Schon, Ariella Shikanov, Erica E. Marsh, Richard Lieberman, Stephen J. Gurczynski, Bethany B. Moore, Jun Z. Li, Sue Hammoud
Summary: This study used single-cell RNA-seq to analyze fallopian tube cells in both healthy and disease states and generated a cell atlas. Changes in epithelial and stromal cell populations were observed in the disease state, along with cell-type-specific alterations in extracellular matrix and TGF-beta signaling, suggesting involvement of fibrosis pathophysiology. This resource is expected to be valuable for further understanding of fallopian tube homeostasis in normal development and disease.
DEVELOPMENTAL CELL
(2022)
Article
Biology
Pol Fernandez-Lopez, Joan Garriga, Isabel Casas, Marc Yeste, Frederic Bartumeus
Summary: Understanding the relationship between sperm motility and fertility is important for both evolutionary and practical purposes. This study characterizes pig sperm motility using t-SNE, a method that reveals a hierarchical organization of sperm motility across individuals and enables accurate fertility predictions. The findings suggest that high-speed and straight-lined motion are positively correlated with fertility and are more important than other sources of variability. The study proposes the use of embedding methods and Bayesian inference frameworks to better understand the relationship between fertility and sperm motility in animals, including humans.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Mengya Zhao, Haihang Nie, Hongling Wang, Jun Fang, Fan Wang, Haizhou Wang, Hualiang Yu, Xiaosong Bai, Yafei Zhang, Qiaozhou Xiong, Hongbing Cai, Qiu Zhao
Summary: This study evaluated the usefulness and feasibility of a novel ultrafine dual-modality oviduct endoscopy device for in vivo assessment of the oviduct. The results showed that both optical coherence tomography (OCT) and ultrasound can visualize the oviduct, but OCT provides better clarity. By comparing OCT images with oviduct histopathology sections, specific layers of the oviduct were identified. This study demonstrated the feasibility and potential clinical value of the novel ultrafine dual-modality oviduct endoscope.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Multidisciplinary Sciences
Taymour M. El-Sherry, Hanan H. Abd-Elhafeez, M. A. M. Sayed
Summary: This study explores the agglutination and motility behavior of Sharkasi chicken sperm using a microfluidic device. The findings suggest that the sperm tend to swim against the flow and form motile bundles. The bundles have lower velocity compared to individual sperm and can adhere to the sidewalls of the microchannel to avoid being swept away by fluid flow.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Medicine, General & Internal
Salvatore Giovanni Vitale, Jose Carugno, Maurizio Nicola D'Alterio, Mislav Mikus, Pasquale Patrizio, Stefano Angioni
Summary: Tubal factor is a significant contributor to female infertility, but current diagnostic approaches are unable to identify many subtle causes of tubal dysfunction accurately. The impact of the resident microbial population on tubal modifications and their interaction with the tubal epithelium has been overlooked.
Article
Chemistry, Analytical
Sai-Xi Yu, Yi Wu, Hao Luo, Yanan Liu, Yu-Chen Chen, Ya-Jun Wang, Wei Liu, Jianan Tang, Huijuan Shi, Hai Gao, Guangyin Jing, Yan-Jun Liu
Summary: Before fertilization, only a limited number of winner sperms can escape from the oviductal surface to reach the egg. By using a microfluidic chip, researchers mimicked the oviduct microenvironment and identified three motion patterns of sperm escape. The study revealed the role of rotational energy in determining whether a sperm is trapped or detaching, and the hammer-throw escaping strategy triggered by biochemical stimulation.
ANALYTICAL CHEMISTRY
(2023)