Article
Biochemistry & Molecular Biology
Shintaro Fujihara, Hideki Kobara, Noriko Nishiyama, Kayo Hirose, Hisakazu Iwama, Tsutomu Masaki
Summary: Esophageal squamous cell carcinoma (ESCC) requires early detection and treatment for improved survival, but diagnosis can be challenging due to observer variation. Studies have shown significant dysregulation of miRNA expression in superficial ESCC, particularly with miR-21-5p, miR-146b-5p, and miR-210-3p. These miRNAs are associated with ESCC invasion depth and lymphovascular invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Sayoko Kinowaki, Yuichi Shimizu, Masayoshi Ono, Yang ZiJian, Ikko Tanaka, Yoshihiko Shimoda, Masaki Inoue, Marin Ishikawa, Keiko Yamamoto, Shoko Ono, Shunsuke Ohnishi, Naoya Sakamoto
Summary: The experimental results indicate that thermal damage in EBD persists until the completion of stenosis, requiring careful operation in the initial stage. The extension effect was only observed at the laceration site and later returned to a status similar to surrounding locations. Additional intervention is needed to prevent restenosis.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Jia-Qi Xu, Zhao-Chao Zhang, Wei-Feng Chen, Mei-Dong Xu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Ping-Hong Zhou, Quan-Lin Li
Summary: Repeat esophageal ESD has shown favorable short-term and long-term outcomes for local recurrence of esophageal squamous cell carcinoma, providing an alternative choice for treatment.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Zi-Han Geng, Yan Zhu, Quan-Lin Li, Pei-Yao Fu, An-Yi Xiang, Hai-Ting Pan, Mei-Dong Xu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Li-Li Ma, Jian-Wei Hu, Ming-Yan Cai, Wen-Zheng Qin, Wei-Feng Chen, Ping-Hong Zhou
Summary: This study aimed to classify the degrees of muscular injury and investigate their association with postoperative esophageal stenosis. The findings revealed that muscular injury was an independent risk factor for esophageal stenosis, and the scoring system showed good performance in predicting muscular injury.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Yosuke Toya, Waku Hatta, Tomohiro Shimada, Tamotsu Matsuhashi, Takeharu Shiroki, Yu Sasaki, Tetsuya Tatsuta, Jun Nakamura, Norihiro Hanabata, Yohei Horikawa, Ko Nagino, Tomoyuki Koike, Atsushi Masamune, Yoshihiro Harada, Tetsuya Ohira, Katsunori Iijima, Yasuhiko Abe, Takuto Hikichi, Shohei Igarashi, Saki Fushimi, Hiroaki Takeda, Shinsaku Fukuda, Takayuki Matsumoto, Tohoku GI Endoscopy Grp
Summary: This multicenter, retrospective cohort study demonstrated the safety and efficacy of endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) with esophageal varices (EVs). The study found high rates of en bloc resection and R0 resection, with a median procedure time of 92 minutes. During the follow-up period, local recurrence and liver metastasis were observed, but no patients died from ESCC.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Tatsunori Minamide, Noboru Kawata, Yuki Maeda, Masao Yoshida, Yoichi Yamamoto, Kazunori Takada, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Junya Sato, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
Summary: This study retrospectively reviewed the clinical outcomes of endoscopic submucosal dissection (ESD) for superficial circumferential esophageal squamous cell carcinoma (cESCC). The results demonstrate that ESD is a highly curative treatment for cESCC with favorable long-term outcomes, especially in low-risk patients.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Oncology
Tsunetaka Kato, Takuto Hikichi, Jun Nakamura, Minami Hashimoto, Ryoichiro Kobashi, Takumi Yanagita, Rei Suzuki, Mitsuru Sugimoto, Yuki Sato, Hiroki Irie, Mika Takasumi, Yuka Oka, Tadayuki Takagi, Yuko Hashimoto, Masao Kobayakawa, Hiromasa Ohira
Summary: This study aimed to evaluate the feasibility and safety of endoscopic submucosal dissection (ESD) in early esophageal cancer after chemoradiotherapy (CRT) by analyzing the association between submucosal fibrosis and ESD. The results showed that although ESD can be reliably performed without adverse events in early esophageal cancer, it is more difficult for lesions with strong submucosal fibrosis, leading to longer procedure time.
Article
Surgery
Di Sun, Qiang Shi, ZhiPeng Qi, Bing Li, Shilun Cai, Pinghong Zhou, Yunshi Zhong
Summary: Simultaneous ESD is an effective and safe method for synchronous multiple EESCC, reducing hospital stay and medical expenses. However, patients with synchronous multiple EESCC have a higher risk of metachronous recurrence, necessitating more intensive treatment strategies.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Tatsunori Minamide, Noboru Kawata, Yuki Maeda, Masao Yoshida, Yoichi Yamamoto, Hiroshi Ashizawa, Kazunori Takada, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Junya Sato, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Takashi Sugino, Hiroyuki Ono
Summary: Through a retrospective study, it was found that the impact of intralesional damage during ESD for esophageal squamous cell carcinoma on local recurrence might be negligible.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biology
Yuki Okubo, Ryu Ishihara
Summary: Endoscopic submucosal dissection (ESD) is widely used for treating superficial esophageal cancer, offering advantages such as high en bloc resection rate and accurate pathological diagnosis. It allows for local resection of the primary tumor and accurate identification of risk factors for lymph node metastasis. Even in clinical T1b-SM cancer, ESD and additional treatment can achieve radical cure based on the risk of lymph node metastasis. Esophageal ESD plays an increasingly vital role in minimally invasive and effective esophageal cancer treatment. This article discusses the current status and prospects of esophageal ESD.
Article
Oncology
She-Gan Gao, Zhi-Peng Qi, Yi-Jun Qi, Ying-Yong Hou, Yi-Wen Liu, Meng-Xiang Li, Bing Li, Di Sun, Qiang Shi, Shi-Lun Cai, Ping-Hong Zhou, Yun-Shi Zhong
Summary: This study aimed to evaluate the impact of P. gingivalis on local recurrence after ESD treatment of early ESCC or HGD. The amount of P. gingivalis was assessed in 205 patients. The study found that overabundance of P. gingivalis was associated with invasion depth, post-ESD stricture, and local recurrence. A nomogram integrating P. gingivalis, lymphovascular involvement, and lesion length performed well for prediction of post-ESD local recurrence.
Article
Medicine, General & Internal
Guodong Yang, Zhao Mu, Ke Pu, Yulin Chen, Luoyao Zhang, Haiyue Zhou, Peng Luo, Xiaoying Zhang
Summary: This study aimed to identify the risk factors for esophageal stricture and develop an accurate scoring model to predict the risk of esophageal stricture. Independent risk factors included age over 60 years, high neutrophil-to-lymphocyte ratio, extent of esophageal mucosal defect over 1/2, and postoperative pathological type of early esophageal squamous cell carcinoma. The scoring model was validated using the area under the receiver operating characteristic curve and showed good prediction performance.
Article
Gastroenterology & Hepatology
So Takahashi, Waku Hatta, Kenta Watanabe, Tomoyuki Koike, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tatsuya Mikami, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Dai Hirasawa, Tetsuya Ohira, Jun Nakamura, Tomohiro Nakamura, Naoki Nakaya, Takayuki Matsumoto, Shinsaku Fukuda, Atsushi Masamune, Katsunori Iijima
Summary: Additional treatment after ESD in patients with pT1a-MM/pT1b-SM ESCC was not associated with an improved prognosis.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Li Wang, Zu-Qiang Liu, Jing-Zheng Liu, Li-Yun Ma, Xiao-Qing Li, Lu Yao, Quan-Lin Li, Ping-Hong Zhou
Summary: ESD is a safe and effective treatment for anastomotic lesions of the lower gastrointestinal tract, with favorable short-term and long-term outcomes.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Takuto Hikichi, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Yuki Sato, Hiroki Irie, Yoshinori Okubo, Masao Kobayakawa, Hiromasa Ohira
Summary: Endoscopic resection is the standard treatment for intramucosal esophageal cancers, but the risk of esophageal stricture post-treatment remains a challenge, especially in cases where the mucosal defect is extensive. Steroid injection therapy and oral steroid administration are mainstream methods for preventing stricture, but may not be effective in cases of circumferential EC. Further studies are needed to explore more effective prophylaxis methods for post-ESD mucosal defects.
JOURNAL OF CLINICAL MEDICINE
(2021)
