Article
Medicine, General & Internal
Tessa M. Hers, Jan Van Schaik, Niels Keekstra, Hein Putter, Jaap F. Hamming, Joost R. Van der Vorst
Summary: The ACS risk calculator demonstrated inadequate predictive performance in the context of aortic aneurysm repair in a Dutch tertiary referral hospital, with some risk predictions lacking discrimination and structural calibration issues. The calculator consistently underestimated the risk of complications, indicating the need for multicenter collaboration to evaluate its performance in aortic surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Tiffany Luu, Brian P. Curran, Alvaro A. Macias, Soraya Mehdipour, Sierra Simpson, Rodney A. Gabriel
Summary: This retrospective cohort study aimed to determine postoperative mortality risk factors and develop a score-based risk calculator using a limited number of preoperative predictors to estimate mortality risk in patients undergoing hepatectomy.
ANESTHESIA AND ANALGESIA
(2023)
Article
Gastroenterology & Hepatology
Subbra Palaniappan, Roy L. Soiza, Siobhan Duffy, Susan J. Moug, Phyo Kyaw Myint
Summary: This study confirms the prognostic role of frailty in the emergency surgical setting, showing that increasing frailty is associated with increased mortality and longer hospital stay in adults of all ages. Although the National Emergency Laparotomy Audit (NELA) performs better, the clinical frailty score (CFS) remains predictive and has the advantage of being calculated preoperatively, aiding decision-making and treatment planning.
COLORECTAL DISEASE
(2022)
Article
Obstetrics & Gynecology
Breffini C. Anglim, George Tomlinson, Joalee Paquette, Colleen D. McDermott
Summary: This study aimed to determine the perioperative characteristics associated with an increased risk of postoperative urinary retention (POUR) following vaginal pelvic floor surgery. Through comparing 18 variables, including age, menopausal status, and intraoperative blood loss, a POUR risk calculator has been developed to help physicians predict the risk of POUR and provide potential management options for patients preoperatively.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Neel P. Chudgar, Shi Yan, Meier Hsu, Kay See Tan, Katherine D. Gray, Daniela Molena, Tamar Nobel, Prasad S. Adusumilli, Manjit Bains, Robert J. Downey, James Huang, Bernard J. Park, Gaetano Rocco, Valerie W. Rusch, Smita Sihag, David R. Jones, James M. Isbell
Summary: The study compared the observed and predicted outcomes after pulmonary resections between SURPAS and NSQIP SRC. Results showed no significant differences in discrimination performance between the two models for most complications, except for renal failure. The NSQIP SRC performed better in discriminating the risk of renal failure compared to SURPAS.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Nerea Gonzalez, Ane Lorono, Urko Aguirre, Santiago Lazaro, Marisa Bare, Maximino Redondo, Eduardo Briones, Cristina Sarasqueta, Amaia Bilbao, Nerea Fernandez de Larrea, Jose Maria Quintana
Summary: This study aimed to identify predictors of mortality in elderly patients undergoing colorectal cancer surgery and developed a risk score based on sociodemographic and clinical data collected prospectively from 18 hospitals in Spain. The predictors of mortality at 2 years after surgery included various factors such as haemoglobin level, ASA class, TNM stage, LODDS, and complications. For mortality between 2 and 5 years after surgery, predictors included factors such as tests performed, complications, age, radiotherapy, colostomy closure, medical complications, tumor recurrence, and readmissions. The study provides important insights for decision-making in the care of elderly colorectal cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Wei Xu, Ines Mesa-Eguiagaray, Theresa Kirkpatrick, Jennifer Devlin, Stephanie Brogan, Patricia Turner, Chloe Macdonald, Michelle Thornton, Xiaomeng Zhang, Yazhou He, Xue Li, Maria Timofeeva, Susan Farrington, Farhat Din, Malcolm Dunlop, Evropi Theodoratou
Summary: The study aimed to develop and validate prediction models for individual colorectal cancer (CRC) risk prediction in patients with gastroenterological symptoms by incorporating demographics, clinical features, and a weighted genetic risk score (wGRS). Various models were developed and evaluated using internal validation. Models that integrated wGRS with demographic and clinical predictors showed improved prediction performance and suggest the potential of genetic predictors in enhancing CRC risk prediction. Further investigation through model external validation and clinical impact is warranted.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Wei-Miao Wu, Kai Gu, Yi-Hui Yang, Ping-Ping Bao, Yang-Ming Gong, Yan Shi, Wang-Hong Xu, Chen Fu
Summary: This study aimed to develop and validate an optimal risk-scoring system for colorectal cancer (CRC) screening. The results indicated the potential of using logistic regression-based scoring systems incorporating fecal immunochemical test (FIT) results in mass screening for CRC.
Article
Gastroenterology & Hepatology
Tommaso Campagnaro, Edoardo Poletto, Paola Tarchi, Simone Rattizzato, Giuseppe Verlato, Simone Conci, Corrado Pedrazzani, Nicolo De Manzini, Alfredo Guglielmi, Andrea Ruzzenente
Summary: The study evaluated the performance of the ACS-NSQIP SRC for patients undergoing surgery for colorectal liver metastases (CRLM). The results showed that the SRC only had good predicting capabilities for cardiac complications, but underestimated other complications and length of hospital stay.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Jie Ping, Yaohua Yang, Wanqing Wen, Sun-Seog Kweon, Koichi Matsuda, Wei-Hua Jia, Aesun Shin, Yu-Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong-Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min-Ho Shin, Chizu Tanikawa, Zhi-Zhong Pan, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Zefang Ren, Xiao-Ou Shu, Jirong Long, Wei Zheng
Summary: PRS constructed using East Asian-specific data showed better performance in predicting colorectal cancer risk compared to PRS constructed using European descendants data. Individuals in the highest 5% risk group had a 2.52-fold elevated risk of colorectal cancer compared to the medium risk group.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Xiangchao Ding, Dan Cheng, Bing Sun, Manda Sun, Chuangyan Wu, Jiuling Chen, Xiaoli Li, Yuan Lei, Yunshu Su
Summary: This study aimed to determine the predictors for severe hypoxemia (SH) in patients undergoing heart valve surgery (HVS) and to develop and validate a risk prediction model. The study identified seven independent risk factors for SH after HVS, including body mass index, chronic obstructive pulmonary disease, renal insufficiency, white blood cell count, serum globulin, cardiopulmonary bypass time, and surgical types. The logistic model based on these predictors showed satisfactory discrimination, calibration, and clinical utility. A nomogram and a risk calculator were generated for easy application.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Florian E. Buisman, Wills F. Filipe, Nancy E. Kemeny, Raja R. Narayan, Rami M. Srouji, Vinod P. Balachandran, Thomas Boerner, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham, Alice C. Wei, Dirk J. Grunhagen, Cornelis Verhoef, Bas Groot Koerkamp, Michael I. D'Angelica
Summary: This study investigated the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases and found that adjuvant HAIP is associated with superior hepatic disease-free survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yih-Jong Chern, Jeng-Fu You, Ching-Chung Cheng, Jing-Rong Jhuang, Chien-Yuh Yeh, Pao-Shiu Hsieh, Wen-Sy Tsai, Chun-Kai Liao, Yu-Jen Hsu
Summary: This study compared the outcomes of open and laparoscopic surgeries in elderly patients with colorectal cancer (CRC) and found that laparoscopic surgery is a favorable method for elderly patients, leading to less pulmonary-related complications and mortality, shorter hospital stay, and similar oncological outcomes.
Article
Multidisciplinary Sciences
Aviv Gafni, Gillian S. Dite, Erika Spaeth Tuff, Richard Allman, John L. Hopper
Summary: Colorectal cancer risk stratification can be significantly improved by incorporating a polygenic risk score with family history, as shown in a study on a UK Biobank cohort. Combining these factors led to better risk distribution, improved risk stratification, and increased discriminatory accuracy for both 10-year and lifetime risk assessments, suggesting potential for enhancing population screening programs.
Article
Medicine, General & Internal
Davit L. Aghayan, Airazat M. Kazaryan, Vegar Johansen Dagenborg, Bard Rosok, Morten Wang Fagerland, Gudrun Maria Waaler Bjornelv, Ronny Kristiansen, Kjersti Flatmark, Asmund Avdem Fretland, Bjorn Edwin
Summary: In this randomized trial comparing laparoscopic and open liver surgery for patients with colorectal liver metastases, there was no significant difference in survival outcomes between the two treatment groups. However, variability in 5-year overall survival rates by up to about 10 percentage points was observed.
ANNALS OF INTERNAL MEDICINE
(2021)
