Letter
Plant Sciences
James Ronald, Anthony J. Wilkinson, Seth J. Davis
Summary: The sub-nuclear localization of EARLY FLOWERING3 gene responds to changes in ambient temperature.
Article
Agronomy
Liping Wang, Anqi Zhou, Lulu Wang, Jing Li, Mingkang Yang, Tingting Duan, Jian Jin, Liang Chen, Liangfa Ge, Wei Huang
Summary: This study elucidated how the core clock gene LUX ARRHYTHMO (LUX) regulates shoot architecture in Medicago truncatula. The results showed that the mtlux mutant had increased main stem height, reduced lateral shoot length, and decreased the number of lateral branches and biomass yield. Gene expression analysis revealed that MtLUX regulates shoot architecture by repressing the expression of strigolactone receptor MtD14 and the TCP gene MtTB1/MtTCP1A. In vivo and in vitro experiments showed that MtLUX directly binds to a cis-element in the promoter of MtTB1/MtTCP1A, suggesting that it rhythmically suppresses MtTB1/MtTCP1A to regulate branching.
Article
Physics, Multidisciplinary
Ying Li, Guang-Kun Zhang, Yan-Ming Ge
Summary: Cyanobacteria have a circadian clock system consisting of a transcriptional/translational feedback loop and a post-translational oscillator. The protein CikA plays a crucial role in the regulation of the circadian clock, enhancing sensitivity and adaptability. Mathematical models have shown that CikA regulation strengthens the central role of the post-translational oscillator and improves the system's ability to modulate its period against environmental changes.
Article
Multidisciplinary Sciences
Eui Min Jeong, Miri Kwon, Eunjoo Cho, Sang Hyuk Lee, Hyun Kim, Eun Young Kim, Jae Kyoung Kim
Summary: In metazoan organisms, circadian rhythms are regulated by pacemaker neurons organized in a master-slave hierarchy. This study reveals the heterogeneity in molecular clockworks between master pacemakers and slave oscillators, with higher PER synthesis and turnover, as well as lower CLK levels in the master pacemakers. The distinct molecular clockwork of the master pacemakers allows them to generate strong rhythms and adapt flexibly to environmental changes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Cell Biology
Zhihui Zhang, Guanghou Shui, Min-Dian Li
Summary: Meal timing can reset cellular circadian clocks in the body, with clocks in different tissues being reset to varying degrees by feeding rhythms, and modulated by the central clock and the liver clock. Tissue-specific regulation and intercellular signaling play essential roles in clock synchronization.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yi Liao, Michael J. Rust
Summary: The study shows that in the cyanobacterium Synechococcus elongatus, the clock generates rhythms in DNA replication to ensure successful completion of genome replication during the night, while providing resources in time to support the process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Carolin Delker, Marcel Quint, Philip A. Wigge
Summary: Plants have the ability to adjust their morphology and development in response to environmental stimuli, a phenomenon known as phenotypic plasticity. In Arabidopsis thaliana, the morphological response to elevated temperatures, termed thermomorphogenesis, is largely regulated by the transcription factor PIF4, which is in turn influenced by various thermosensing mechanisms and modulators. Recent advances have identified factors that affect PIF4 expression and activity, and have shed light on organ- and tissue-specific regulation of thermomorphogenesis.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Review
Oncology
Ewan M. Stephenson, Laura E. J. Usselmann, Vinay Tergaonkar, David M. Virshup, Robert Dallmann
Summary: Circadian rhythms play a significant role in cancer biology, with clock genes impacting tumourigenesis through various pathways. However, the function of the clock can be both pro- and anti-tumourigenic depending on the model and cell type. To fully understand the role of the circadian clock in tumors, analysis of molecular clock status compared to healthy tissue is necessary.
ENDOCRINE-RELATED CANCER
(2021)
Article
Environmental Sciences
Cuimei Li, Linlin Zhang, Tiantian Ma, Lei Gao, Luda Yang, Meina Wu, Zhaoxia Pang, Xiaoyu Wang, Qiyang Yao, Yaoyao Xiao, Lijia Zhao, Wei Liu, Hongcong Zhao, Caixia Wang, Aihua Wang, Yaping Jin, Huatao Chen
Summary: This study demonstrates that BPA disrupts testosterone production by inhibiting NR1D1 signaling in Leydig cells, leading to a decrease in testosterone levels in mice. Additionally, circadian clock genes are also involved in this process.
Article
Biochemistry & Molecular Biology
Sang Ah Yi, Ye Ji Jeon, Min Gyu Lee, Ki Hong Nam, Sora Ann, Jaecheol Lee, Jeung-Whan Han
Summary: This study reveals that S6K1 plays a central role in regulating the production of adiponectin, a hormone derived from fat cells that has beneficial effects on metabolism. S6K1 controls adiponectin expression by inducing a transcriptional switch between two transcriptional machineries, BMAL1 and EZH2. Mechanistically, S6K1 induces a suppressive histone code cascade, leading to suppression of adiponectin expression. Upon fasting, inactivation of S6K1 promotes adiponectin expression by inducing a transcriptional switch from EZH2 to BMAL1. These findings provide insights into the regulatory machinery controlling adiponectin production and may guide the development of treatments for metabolic disorders.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Yongtao Yu, Sergi Portoles, Yi Ren, Guangyu Sun, Xiao-Fang Wang, Huihui Zhang, Shaogui Guo
Summary: The F-box protein ZEITLUPE (ZTL) negatively regulates ABA signaling in Arabidopsis thaliana during early seedling growth and stomatal closure induced by ABA. ZTL interacts with and ubiquitinates its substrate CHLH/ABAR to modulate CHLH stability. ABA induces ZTL phosphorylation and CHLH degradation, suggesting a reciprocal regulation mechanism between ABA signaling and the circadian clock.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Hikari Ikeda, Taiga Uchikawa, Yohei Kondo, Nozomu Takahashi, Takuma Shishikui, Masaaki K. Watahiki, Akane Kubota, Motomu Endo
Summary: Plants adapt to environmental changes through circadian clocks, and this study found that root hair elongation in Arabidopsis is controlled by both light and the circadian clock. Genes encoding major components of the central oscillator regulate the rhythmicity of root hair length. Grafting experiments showed that TOC1 in shoots is responsible for the generation of root hair rhythmicity.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Immunology
Dechao Feng, Qiao Xiong, Facai Zhang, Xu Shi, Hang Xu, Wuran Wei, Jianzhong Ai, Lu Yang
Summary: This study establishes a new approach to predict the progression of prostate cancer patients based on a gene signature related to circadian clock, providing insights into the tumor immune microenvironment. The findings suggest the potential use of circadian rhythm-related genes in risk stratification and highlight the importance of the tumor immune microenvironment in prostate cancer progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Maayan Dadon-Freiberg, Nava Chapnik, Oren Froy
Summary: This study demonstrates that leucine inhibits liver mTORC1 pathway leading to dampened circadian rhythms, while REV-ERB alpha activates the mTORC1 pathway, resulting in phosphorylation of the clock protein BMAL1.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Anatomy & Morphology
Yuzhen Chen, Fudong Zheng
Summary: The study reveals that the circadian Clock affects the activities of PRL. Using Clock gene knockout mice, researchers found that PRL-induced signaling was significantly reduced in Clock(-/-) mice, both in vitro and in vivo. The upregulation of negative regulatory molecule SOCS may be one of the factors causing the downregulation of PRL signaling.
Article
Plant Sciences
Kotaro Torii, Akane Kubota, Takashi Araki, Motomu Endo
PLANT AND CELL PHYSIOLOGY
(2020)
Article
Engineering, Electrical & Electronic
Yoji Yabe, Hisa-Aki Tanaka, Hiroo Sekiya, Masaki Nakagawa, Fumito Mori, Kensuke Utsunomiya, Akira Keida
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2020)
Article
Biochemistry & Molecular Biology
Sabrina Fluetsch, Yizhou Wang, Atsushi Takemiya, Silvere R. M. Vialet-Chabrand, Martina Klejchova, Arianna Nigro, Adrian Hills, Tracy Lawson, Michael R. Blatt, Diana Santelia
Review
Plant Sciences
Shohei Yamaoka, Keisuke Inoue, Takashi Araki
Summary: The liverwort Marchantia polymorpha regulates gametangia and gametangiophore development using evolutionarily conserved regulatory modules shared with angiosperms. These modules were likely acquired by a common ancestor of land plants before the divergence of bryophytes.
PLANT REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Fumito Mori, Hiroshi Kori
Summary: In this paper, we propose theoretical methods to simultaneously infer coupling strength and noise intensity in two well-synchronized noisy oscillators through observations of spontaneously fluctuating events. Our methods do not require external perturbations and can be applied to various experimental systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Nanaka Murakami, Saashia Fuji, Shota Yamauchi, Sakurako Hosotani, Jun'ichi Mano, Atsushi Takemiya
Summary: Reactive oxygen species (ROS) inhibit blue light (BL) signaling, especially H+-ATPase activation, which plays a key role in plant responses to biotic and abiotic stresses.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kazusato Oikawa, Shino Goto-Yamada, Yasuko Hayashi, Daisuke Takahashi, Yoshitaka Kimori, Michitaro Shibata, Kohki Yoshimoto, Atsushi Takemiya, Maki Kondo, Kazumi Hikino, Akira Kato, Keisuke Shimoda, Haruko Ueda, Matsuo Uemura, Keiji Numata, Yoshinori Ohsumi, Ikuko Hara-Nishimura, Shoji Mano, Kenji Yamada, Mikio Nishimura
Summary: Pexophagy plays a pivotal role in selectively removing ROS-generating peroxisomes under high-intensity light, which protects plants from oxidative damage during photosynthesis.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Hotaka Kaji, Fumito Mori, Hiroshi Ito
Summary: This study investigated the fluctuations in the oscillation period of the circadian clock and its output system. The results showed that the output system has smaller fluctuations compared to the circadian clock, suggesting that it can improve the accuracy of the circadian rhythm.
JOURNAL OF THEORETICAL BIOLOGY
(2023)
Article
Physics, Multidisciplinary
Fumito Mori, Takashi Okada
Summary: Information processing in biological systems relies on the transmission of information flows over complex networks. These networks are influenced by input signal characteristics and structural properties, and often include network motifs that play important roles in biological functions. However, the information-theoretic properties of these motifs and their dependence on input signals are poorly understood.
PHYSICAL REVIEW RESEARCH
(2023)
Article
Multidisciplinary Sciences
Satoyuki Hirano, Kotoko Sasaki, Yasuhide Osaki, Kyoka Tahara, Hitomi Takahashi, Atsushi Takemiya, Yutaka Kodama
Summary: The plasma membrane-associated phot functions as the cellular compartment for cold sensing in plants.
Article
Biochemistry & Molecular Biology
Sakurako Hosotani, Shota Yamauchi, Haruki Kobayashi, Saashia Fuji, Shigekazu Koya, Ken-ichiro Shimazaki, Atsushi Takemiya
Summary: The study shows that blue light-induced stomatal opening in plants is mediated by the BLUS1 signaling pathway, which regulates the opening and closure of stomata, thereby affecting CO2 uptake and transpiration.
Article
Physics, Multidisciplinary
Fumito Mori, Takashi Okada
PHYSICAL REVIEW RESEARCH
(2020)