Review
Allergy
Giulia C. Spolidoro, Yohannes Tesfaye Amera, Mohamed Mustafa Ali, Sungkutu Nyassi, Daniil Lisik, Athina Ioannidou, Graciela Rovner, Ekaterina Khaleva, Carina Venter, Ronald van Ree, Margitta Worm, Berber Vlieg-Boerstra, Aziz Sheikh, Antonella Muraro, Graham Roberts, Bright Nwaru
Summary: The latest estimates of food allergy prevalence and trends in Europe show an increase in self-reported food allergy and sensitization rates. This may be due to a real increase in the prevalence, increased awareness, increased evaluation of food types, or increased number of studies. Future studies need to use standardized methods, including double-blinded placebo-controlled food challenge, to minimize potential biases.
Review
Cardiac & Cardiovascular Systems
Marco Zuin, Loris Roncon, Angela Passaro, Carlo Cervellati, Giovanni Zuliani
Summary: The study found a significant association between metabolic syndrome (MetS) and Alzheimer's disease (AD), mainly supported by large retrospective studies. Individual components of MetS are also associated with AD incidence, with increased waist circumference possibly having a protective role.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Neurosciences
Woon-Man Kung, Sheng-Po Yuan, Muh-Shi Lin, Chieh-Chen Wu, Md. Mohaimenul Islam, Suleman Atique, Musa Touray, Chu-Ya Huang, Yao-Chin Wang
Summary: This study found a significant association between anemia and cognitive impairment, with anemia patients having an almost 1.39 times higher risk of developing OCI compared to non-anemic individuals. Particularly in elderly patients, the magnitude of this risk emphasizes the importance of improving health outcomes for anemia patients.
Review
Surgery
Ned Kinnear, Samantha Jolly, Matheesha Herath, Jennie Han, Minh Tran, Michael O'Callaghan, Derek Hennessey, Christopher Dobbins, Tarik Sammour, James Moore
Summary: The systematic review of comparative studies on the Acute Surgical Unit (ASU) model revealed that compared to the Traditional model, the ASU model is associated with reduced length of stay, after-hours operating rates, complications, and improved outcomes for most metrics, including reduced time to surgical review, time to theatre, and mortality. Promoting the introduction of ASU should be considered in policy for widespread benefits.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Review
Medicine, General & Internal
Meng-shi Li, Yang Li, Yang Liu, Xu-jie Zhou, Hong Zhang
Summary: Lipoprotein glomerulopathy (LPG) has seen a rapid increase in case reports in recent years, impacting cardiovascular health and lipid profiles. Mutations in the APOE gene are a leading cause of LPG, necessitating further research on disease mechanisms and recent epidemiological data.
FRONTIERS IN MEDICINE
(2022)
Review
Allergy
Giulia C. I. Spolidoro, Mohamed Mustafa Ali, Yohannes Tesfaye Amera, Sungkutu Nyassi, Daniil Lisik, Athina Ioannidou, Graciela Rovner, Ekaterina Khaleva, Carina Venter, Ronald van Ree, Margitta Worm, Berber Vlieg-Boerstra, Aziz Sheikh, Antonella Muraro, Graham Roberts, Bright I. Nwaru
Summary: In 2014, the European Academy of Allergy and Clinical Immunology published prevalence estimates for food allergy and food sensitization to eight major food allergens. This study provides updated prevalence estimates for these food allergens over the past 10 years. The study found that the prevalence of allergy to common foods in Europe has not substantially changed, with some regional variations.
Review
Pharmacology & Pharmacy
Dongliang Liu, Yue Hu, Dali Wang, Hezhou Han, Yi Wang, Xilu Wang, Zhaoyu Zhou, Xiulan Ma, Yaodong Dong
Summary: Tinnitus, the perception of sound in the absence of external stimuli, is prevalent in adults and particularly the elderly. It can lead to cognitive decline and significantly impact quality of life. While various interventions have been used, there are no approved drugs for tinnitus treatment, although herbal medicines such as Ginkgo biloba are commonly used. This literature review evaluates the efficacy of herbal medicines in the treatment of tinnitus and highlights the issues in existing clinical trials, which have inconsistent conclusions due to insufficient evidence.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Yung-Shuo Kao, Cheng-Chang Yeh, Yi-Fang Chen
Summary: As cancer treatments improve, more patients survive cancer, but treatment-related complications such as cognitive impairment become more common. Recent research suggests a link between cancer and dementia, and progress has been made in understanding the cognitive changes associated with cancer treatment. However, more needs to be done to prevent and screen early for dementia in cancer survivors. This review summarizes the current literature on cognitive impairment in patients with various types of cancer and discusses potential risk factors and mechanisms of neurodegeneration caused by cancer treatment.
Review
Neurosciences
Nadine Sontheimer, Alexander Konnopka, Hans-Helmut Koenig
Summary: This study systematically reviewed excess cost studies for dementia and found that demented individuals have significantly higher costs at the time of diagnosis and between diagnosis and death. Costs were highest for professional home care and nursing facilities during the time period between diagnosis and death. This meta-analysis demonstrated that dementia constitutes a significant economic burden.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Virology
Jun Yang, Congmin Tian, Ying Chen, Chunyan Zhu, Hongyu Chi, Jiahao Li
Summary: This review evaluated the impact of obesity on COVID-19 and found that obese individuals were more likely to test positive for the virus and had higher risks of hospitalization, ICU admission, invasive mechanical ventilation, and in-hospital mortality. A higher degree of obesity also indicated higher risks, and regional differences may contribute to study heterogeneity. Further research is needed to strengthen basic and clinical therapeutic approaches.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Geriatrics & Gerontology
Nanyang Liu, Yi Wang, Lanye He, Jiahui Sun, Xing Wang, Hao Li
Summary: The study found that a previous diagnosis of inflammatory bowel disease (IBD) does not seem to increase the risk of subsequent all-cause dementia and AD-dementia. Cohort studies show a positive association between IBD patients and all-cause dementia, but it is not related to age and gender.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Yong Qi Leong, Shaun Wen Huey Lee, Khuen Yen Ng
Summary: The study revealed that Parkinson's disease patients have lower risks of certain cancers but higher risks of melanoma and brain cancer. Additionally, there were negative associations between PD patients and risks of colon cancer, rectal cancer, and non-Hodgkin lymphoma. Further research is needed to explore the underlying mechanisms between PD and cancers.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Nutrition & Dietetics
Dhan Bahadur Shrestha, Pravash Budhathoki, Yub Raj Sedhai, Sujit Kumar Mandal, Shreeja Shikhrakar, Saurab Karki, Ram Kaji Baniya, Markos G. Kashiouris, Xian Qiao, Alpha A. Fowler
Summary: Vitamin C has benefits in critically ill patients, reducing the risk of in-hospital mortality and shortening ICU stays, with relatively good safety performance.
Review
Geriatrics & Gerontology
Xiaoyan Li, Jie He, Qiuhua Sun
Summary: This study qualitatively and quantitatively summarized previous research on sleep duration and sarcopenia risk, and found a correlation between sleep duration and sarcopenia risk, especially in older adults. The prevalence of sarcopenia was relatively high in adults with a long duration of sleep.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Geriatrics & Gerontology
Qianwen Wang, Jingjing Zhao, Hongtao Chang, Xu Liu, Ruixia Zhu
Summary: Recent studies suggest a potential role of homocysteine (Hcy) and folate in the pathogenesis of vascular dementia (VaD) and Alzheimer's disease (AD). Elevated Hcy levels and decreased folate levels are associated with an increased risk of dementia, AD, and VaD. Additionally, every 5 μmol/L increase in plasma Hcy level is linked to a 9% higher risk of dementia and a 12% higher risk of AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto
Summary: This study estimated the potential cost-effectiveness of the FINGER program in Finland. The results showed that the FINGER program could save costs and improve quality-adjusted life years, supporting its effectiveness in preventing cognitive impairment and disability.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Ron L. H. Handels, Colin Green, Anders Gustavsson, William L. Herring, Bengt Winblad, Anders Wimo, Anders Skoldunger, Andreas Karlsson, Robert Anderson, Mark Belger, Chiara Bruck, Robert Espinosa, Jakub P. Hlavka, Eric Jutkowitz, Pei-Jung Lin, Mauricio Lopez Mendez, Javier Mar, Peter Shewmaker, Eldon Spackman, Ali Tafazzoli, Bryan Tysinger, Linus Jonsson
Summary: This article reports on the results of the International PharmacoEconomic Collaboration on Alzheimer's Disease (IPECAD) Modeling Workshop Challenge. Participants jointly developed two common benchmark scenarios for the treatment of Alzheimer's disease and conducted model comparisons and discussions. The results showed a high level of agreement among participants, which is important for establishing transparent and credible Alzheimer's disease models.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Arenda Mank, Judith J. M. Rijnhart, Ingrid S. van Maurik, Linus Jonsson, Ron Handels, Els D. Bakker, Charlotte E. Teunissen, Bart N. M. van Berckel, Argonde C. van Harten, Johannes Berkhof, Wiesje M. van der Flier
Summary: This study compared the trajectories of quality of life (QoL) between amyloid-positive and amyloid-negative patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI). The results showed that amyloid-positive patients had a faster decline in QoL over time compared to amyloid-negative patients. QoL decreased along the Alzheimer's disease continuum, with the steepest decrease in dementia patients.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Anders Wimo, Katrin Seeher, Rodrigo Cataldi, Eva Cyhlarova, Joseph L. Dielemann, Oskar Frisell, Maelenn Guerchet, Linus Jonsson, Angeladine Kenne Malaha, Emma Nichols, Paola Pedroza, Martin Prince, Martin Knapp, Tarun Dua
Summary: Dementia is a major cause of death and disability worldwide. A global cost model was constructed to estimate the total societal costs of dementia, including direct and indirect economic costs. In 2019, the annual global societal costs of dementia were estimated to be $1313.4 billion, with the highest costs seen in high-income countries.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg T, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Ron Handels, Sabine Grimm, Arjan Blokland, Nina Possemis, Inez Ramakers, Anke Sambeth, Frans Verhey, Stephanie Vos, Manuela Joore, Jos Prickaerts, Linus Jonsson
Summary: Early health-technology assessment is important in discussing resource allocation. This study explored the value of maintaining cognition in patients with mild cognitive impairment (MCI) through the potential cost effectiveness of roflumilast treatment. The results suggest that further research on the effect of roflumilast on dementia onset is valuable.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Robin Ziyue Zhou, Davide Liborio Vetrano, Giulia Grande, Frida Duell, Linus Jonsson, Erika J. Laukka, Claudia Fredolini, Bengt Winblad, Lars Tjernberg, Sophia Schedin-Weiss
Summary: This study suggests that the levels of bisecting N-acetylglucosamine and total tau in blood are associated with Alzheimer's disease (AD). Individuals with an intermediate tau/bisecting N-acetylglucosamine ratio have an elevated risk of AD. Furthermore, a combined model including this ratio, apolipoprotein E (APOE) e4 status, and Mini-Mental State Examination score can predict future AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Ashley E. Tate, Vincent Bouteloup, Ingrid S. van Maurik, Delphine Jean, Arenda Mank, Andreja Speh, Valerie Boilet, Argonde van Harten, Maria Eriksdotter, Anders Wimo, Carole Dufouil, Wiesje M. van der Flier, Linus Joensson
Summary: This study aimed to determine the timeline from mild cognitive impairment (MCI) to death and found that the sojourn time was associated with age, gender, and disease diagnosis, providing important estimates for researchers and clinicians to predict prognosis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Sandar Aye, Linus Jonsson, Anders Gustavsson, Ashley Tate, Sara Garcia Ptacek, Maria Eriksdotter
Summary: This study examined the mortality attributed to Alzheimer's disease (AD) and its impact on the cost-effectiveness of disease-modifying treatment (DMT). The results showed that overall mortality increased with cognitive decline, age, male sex, number of medications used, and lower body mass index. The study also modeled the effect of DMT on AD survival and found that it increased survival and improved cost-effectiveness.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Clinical Neurology
Sandar Aye, Vincent Bouteloup, Ashley Tate, Anders Wimo, Ron Handels, Delphine Jean, Bengt Winblad, Linus Joensson
Summary: Health utility estimates for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are limited, especially in biomarker-confirmed populations. This study provides health utility estimates for SCD and MCI, revealing a decline in HR-QoL over time in moderate and severe dementia, and a negative association between clinical stage and VAS. Amyloid-positive patients show a faster decline in health utility, emphasizing the importance of considering biomarker status in HR-QoL assessments.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Meeting Abstract
Clinical Neurology
Linus Jonsson, Susanne F. Awad, Stephane A. Regnier, Brian Talon, Steven Kymes, Xin Ying Lee, Peter J. Goadsby
Meeting Abstract
Clinical Neurology
Linus Jonsson, Stephane A. Regnier, Steven Kymes, Brian Talon, Susanne F. Awad, Xin Ying Lee, Peter J. Goadsby
Meeting Abstract
Economics
A. Tate, L. Jonsson
Meeting Abstract
Economics
L. Jonsson, S. A. Regnier, S. Kymes, S. F. Awad, B. Talon, X. Y. Lee, P. J. Goadsby