Article
Pharmacology & Pharmacy
Rana E. Kamal, Esther Menze, Amgad Albohy, Hebatalla I. Ahmed, Samar S. Azab
Summary: This study evaluated the potential of carvedilol as an anti-Parkinson's drug and anti-tau protein target through computational simulation and in vivo experiments. The results suggest that carvedilol has neuro-protective effects and may be a candidate for the management of Parkinson's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Madiha Rasheed, Junhan Liang, Chaolei Wang, Yulin Deng, Zixuan Chen
Summary: Neuroinflammation plays a significant role in the initiation and progression of Parkinson's disease, activating the neuronal immune system and triggering a vicious cycle of inflammation-induced dopaminergic neuron damage. Epigenetic mechanisms are at the forefront of regulating neuroinflammatory factors, offering potential for breaking this cycle. These mechanisms do not work independently but cooperatively, impacting various neuroinflammatory pathways and potentially influencing PD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Patrycja Mulica, Anne Gruenewald, Sandro L. Pereira
Summary: Declining brain energetics play a role in aging and neurodegenerative diseases like Alzheimer's and Parkinson's. Recent evidence suggests that astrocytes, key in supporting neuronal function, may also contribute to the development of these diseases. Understanding the metabolic interactions between astrocytes and neurons, particularly regarding mitochondria, has therapeutic potential in addressing neurodegenerative disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Xiaoyi Xu, Xin He, Zeyan Zhang, Yanyi Chen, Junyu Li, Shanshan Ma, Qiaoying Huang, Mingtao Li
Summary: This study identified that the inactivation of CREB and decreased expression of NURR1 are associated with nigral dopaminergic neurodegeneration in Parkinson's disease (PD). The mechanism underlying CREB inactivation involves the interaction between HDAC1/PP1y complex and CREB, and disrupting this interaction can restore CREB activity and protect dopaminergic neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Linn Streubel-Gallasch, Veronica Giusti, Michele Sandre, Isabella Tessari, Nicoletta Plotegher, Elena Giusto, Anna Masato, Ludovica Iovino, Ilaria Battisti, Giorgio Arrigoni, Derya Shimshek, Elisa Greggio, Marie-Eve Tremblay, Luigi Bubacco, Anna Erlandsson, Laura Civiero
Summary: This study compared the ability of astrocytes carrying PD-linked gene mutations with normal astrocytes in handling α-synuclein, finding a decreased clearance capacity in mutant cells linked to a loss of function in AnxA2.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yang Liu, Ting Liu, Yuanzhang Zhou, Wenjie Li, Min Wang, Nanshan Song, Wenbin Zhang, Jingwei Jiang, Shengtao Yuan, Jianhua Ding, Gang Hu, Ming Lu
Summary: The study demonstrates the involvement of ASCT2 in the progression of Parkinson's disease, with high expression correlated with dyskinesia. It further shows that genetic ablation of astrocytic ASCT2 alleviates neuroinflammation and rescues dopaminergic neuron damage. The drug talniflumate, identified through virtual molecular screening, inhibits astrocytic inflammation and prevents degeneration of dopaminergic neurons in Parkinson's disease models.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Neurosciences
Samanta Mazzetti, Michela Barichella, Federica Giampietro, Angelica Giana, Alessandra M. Calogero, Alida Amadeo, Nicola Palazzi, Alessandro Comincini, Giorgio Giaccone, Manuela Bramerio, Serena Caronni, Viviana Cereda, Emanuele Cereda, Graziella Cappelletti, Chiara Rolando, Gianni Pezzoli
Summary: This study found a specific subpopulation of astrocytes in the brains of Parkinson's disease (PD) patients, which can protect neurons by sequestering alpha-Synuclein oligomers and are associated with Lewy body negative neurons. These findings suggest the potential neuroprotective role of the vitamin D pathway in neurodegenerative diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Aya Yassin Labib, Ramy M. Ammar, Reem N. El-Naga, Alshaymaa Amin Zaki El-Bahy, Mariane G. Tadros, Haidy E. Michel
Summary: The study demonstrated the neuroprotective effects of paracetamol (PCM) against rotenone-induced Parkinson's disease (PD) symptoms. PCM alleviated motor impairments, prevented weight loss, restored tissue structure, and reversed reduction in dopamine content. Additionally, PCM exhibited antioxidant, anti-inflammatory, anti-apoptotic activities, and modulated cannabinoid receptors to protect against PD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jialong Chen, Mingque Li, Xueqiong Zhou, Ailun Xie, Ziwei Cai, Chunlai Fu, Yongming Peng, He Zhang, Linhua Liu
Summary: The study revealed a novel feedback mechanism of p38-Parkin-ROS regulating rotenone-induced Parkinson's disease. Both p38 activation and Parkin inactivation contribute to the disruption of Parkin-mediated mitophagy, leading to increased reactive oxygen species (ROS) production. Inhibiting p38 and enhancing Parkin activity can reduce ROS levels and restore cell death and mitochondrial function in rotenone-induced PD models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Multidisciplinary Sciences
Abolaji Samson Olagunju, Foysal Ahammad, Abiola Adeyanju Alagbe, Titilayomi Ayomide Otenaike, John Oluwafemi Teibo, Farhan Mohammad, Ahad Amer Alsaiari, Olabode Omotoso, Md Enamul Kabir Talukder
Summary: Mitochondrial dysfunction plays a crucial role in various neurodegenerative diseases. Changes in mitochondrial homeostasis are associated with the onset of Alzheimer's and Parkinson's diseases. Early mitochondrial dysfunctions may contribute to the progression of neuropathological processes.
Article
Biochemistry & Molecular Biology
Fatemeh Mamashli, Ali Akbar Meratan, Atiyeh Ghasemi, Nahal Obeidi, Bahram Salmani, Deyhim Atarod, Mitra Pirhaghi, Faezeh Moosavi-Movahedi, Mahya Mohammad-Zaheri, Mohammad Bagher Shahsavani, Zahra Habibi-Kelishomi, Bahram Goliaei, Mahdi Gholami, Ali Akbar Saboury
Summary: This study compared the neuroprotective effects of bulk and nano forms of propolis polyphenolic fraction (PFP) against Parkinson's disease models. The results showed that the nano form of PFP was more effective in reducing oxidative stress, improving antioxidant enzyme activity, and protecting animals from Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Aaina Singh Rathore, Saumitra Sen Singh, Hareram Birla, Walia Zahra, Priyanka Kumari Keshri, Hagera Dilnashin, Richa Singh, Shekhar Singh, Surya Pratap Singh
Summary: This study aimed to investigate the neuroprotective potential of curcumin in Parkinson's disease by activating autophagy through the Nrf2-Keap1 pathway. The results showed that curcumin restored motor coordination and anti-oxidative activity while improving mitochondrial functioning. It also enhanced autophagy-mediated clearance of misfolded alpha-syn proteins and blocked apoptotic cascade. Curcumin is a Nrf2-inducer and may be a potential candidate for anti-Parkinson's disease treatment therapy.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Saba Ubaid, Shivani Pandey, Mohd. Sohail Akhtar, Mohammad Rumman, Babita Singh, Abbas Ali Mahdi
Summary: The study found that SIRT1 in the CLOA complex helps inhibit oxidative stress, reduce cellular protein death, and suppress neuroinflammation. The results suggest that the CLOA complex could be a novel therapeutic molecule to ameliorate neuronal cell damage in PD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Domenico Plantone, Guido Primiano, Carlo Manco, Sara Locci, Serenella Servidei, Nicola De Stefano
Summary: Vitamin D has various effects on the nervous system and its deficiency can increase the risk of developing neurological diseases. Recent studies aim to understand the different outcomes of vitamin D supplementation in progressive neurological diseases. This review provides an overview of vitamin D chemistry, metabolism, mechanisms of action, recommended daily intake, and its role in gene transcription and the immune response. The scientific evidence linking low vitamin D concentrations to severe neurological diseases is discussed, and ongoing clinical trials on vitamin D supplementation in neurological diseases are listed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Antonia Pignolo, Sergio Mastrilli, Chiara Davi, Valentina Arnao, Paolo Aridon, Felipe Augusto dos Santos Mendes, Cesare Gagliardo, Marco D'Amelio
Summary: Vitamin D plays a crucial role in bone metabolism, calcium and phosphorous homeostasis, as well as brain development and neuroprotection. Patients with Parkinson's disease often have a high frequency of vitamin D deficiency, which may be related to disease severity and progression. However, the evidence regarding the use of vitamin D supplementation to reduce symptoms and disability in patients with Parkinson's disease is limited. Further clinical studies are needed to confirm the potential benefits and risks of vitamin D supplementation in this population.
Article
Medicine, Research & Experimental
Emanuel Paula Magalhaes, Brenna Pinheiro Silva, Natalia Luna Aires, Lyanna Rodrigues Ribeiro, Arif Ali, Mariana Maciel Cavalcanti, Joao Victor Serra Nunes, Tiago Lima Sampaio, Ramon Roseo Paula Pessoa Bezerra de Menezes, Alice Maria Costa Martins
Summary: This study evaluated the protective effect of α-bisabolol (BIS) against amphotericin B (AmB)-induced nephrotoxicity. BIS pretreatment increased cell viability, inhibited cell death, reduced reactive oxygen species (ROS) accumulation, improved mitochondrial function, and prevented kidney injury molecule-1 (KIM-1) release. These findings suggest that BIS has potential as a nephroprotective agent.
Article
Chemistry, Physical
Maria Geysillene Castro Matos, Leonardo Paes da Silva, Francisco Wagner Queiroz Almeida-Neto, Emanuelle Machado Marinho, Ramon Roseo Paula Pessoa Bezerra de Menezes, Tiago Lima Sampaio, Matheus Nunes da Rocha, Lyanna Rodrigues Ribeiro, Emanuel Paula Magalhaes, Alexandre Magno Rodrigues Teixeira, Helcio Silva dos Santos, Emmanuel Silva Marinho, Pedro De Lima-Neto, Alice Maria Costa Martins, Norberto K. Monteiro, Marcia Machado Marinho
Summary: This study investigated the inhibitory effects of chalcone as a potential treatment for Chagas disease caused by Trypanosoma cruzi. The results showed that chalcone reduced cell viability, inhibited the proliferation of epimastigote forms, and eliminated trypomastigote forms, indicating its potential as an anti-T. cruzi agent. Furthermore, in silico studies suggested that chalcone had a higher affinity for the enzyme cruzain compared to the reference drug BZN and demonstrated promising pharmacokinetic characteristics.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Debora H. Almeida de Brito, Francisco W. Q. Almeida-Neto, Lyanna R. Ribeiro, Emanuel P. Magalhaes, Ramon R. P. P. Bezerra de Menezes, TiagoL. Sampaio, Alice M. C. Martins, Paulo N. Bandeira, Marcia M. Marinho, Emmanuel S. Marinho, Antonio C. H. Barreto, Pedro de Lima-Neto, Gilberto D. Saraiva, Kirley M. Canuto, Helcio S. dos Santos, Alexandre M. R. Teixeira, Nagila M. P. Silva Ricardo
Summary: The study investigated the inhibitory effects of the chalcone BNZTHP against T. cruzi, demonstrating higher activity on trypomastigote forms and a more powerful inhibitory effect compared to benznidazole. Molecular docking studies indicated good affinity of the compound towards key enzymes in T. cruzi, making it a promising candidate for Chagas disease treatment development.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Francisco Rogenio Silva Mendes, Antonio Wlisses da Silva, Maria Kueirislene Amancio Ferreira, Emanuela de Lima Reboucas, Emanuelle Machado Marinho, Marcia Machado Marinho, Paulo Nogueira Bandeira, Alexandre Magno Rodrigues Teixeira, Jane Eire Silva Alencar de Menezes, Erlania Alves de Siqueira, Ramon Roseo Paula Pessoa Bezerra de Menezes, Emmanuel Silva Marinho, Helcio Silva Dos Santos
Summary: The study confirmed the anxiolytic and anticonvulsant effects of synthetic chalcone FURCHAL, which may act on GABA(A) receptors to produce these effects.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ludmila Araujo de Lima, Pedro Lourenzo Oliveira Cunha, Iana Bantim Felicio Calou, Kelly Rose Tavares Neves, Heberty Tarso Facundo, Glauce Socorro de Barros Viana
Summary: Vitamin D3 (VD3) has neuroprotective effects on a PD model and can prevent the impairment of brain mitochondrial function caused by 6-OHDA. VD3 supplementation also protects the PD brain from damage to the dopamine system and mitochondrial markers.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Parasitology
Yasmim Mendes Rocha, Emanuel Paula Magalhaes, Marlos de Medeiros Chaves, Marcia Machado Marinho, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Tiago Lima Sampaio, Ramon R. P. P. B. de Menezes, Alice M. C. Martins, Roberto Nicolete
Summary: This study evaluated the activity of a 1,2,4-oxadiazole derivative on the evolutionary forms of Trypanosoma cruzi strain Y and studied its mechanisms of action using computational methods. The compound showed good affinity with important targets and displayed a reduction in the number of infected cells and amastigotes. These findings suggest that this oxadiazole derivative holds promise for the development of new drugs for Chagas disease.
PARASITOLOGY RESEARCH
(2022)
Article
Chemistry, Medicinal
Maria Janice Pereira Lopes, Gyllyandeson de Araujo Delmondes, Giovana Mendes de Lacerda Leite, Debora Rejane Alves Cavalcante, Pedro Everson Alexandre de Aquino, Francisco Arnaldo Viana de Lima, Kelly Rose Tavares Neves, Andrea Santos Costa, Hermogenes David de Oliveira, Cicero Francisco Bezerra Felipe, Iri Sandro Pampolha Lima, Marta Regina Kerntopf, Glauce Socorro de Barros Viana
Summary: This study found that the protein fraction from Spirulina platensis can improve behavioral impairments in hemiparkinsonian rats. It exerts neuroprotective effects through anti-inflammatory and antioxidative actions.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Biochemistry & Molecular Biology
Carlos Henrique Leitao Cavalcante, Francisco Wagner de Queiroz Almeida-Neto, Matheus Nunes da Rocha, Paulo Nogueira Bandeira, Ramon Roseo Paula Pessoa Bezerra de Menezes, Emanuel Paula Magalhaes, Tiago Lima Sampaio, Emmanuel Silva Marinho, Marcia Machado Marinho, Alice Maria Costa Martins, Helcio Silva dos Santos
Summary: Chagas disease, characterized as a neglected infection, affects millions of people annually. A study has found that the synthetic chalcone CPN2F has anti-Chagas activity and inhibits the growth of the parasite. Furthermore, the study shows that CPN2F has low toxicity and could be a potential drug for Chagas disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Roberta Oliveira da Costa, Carlos Vinicius Jatai Gadelha-Filho, Pedro Everson Alexandre de Aquino, Ludmila Araujo Rodrigues Lima, Jalles Dantas de Lucena, Wesley Lyeverton Correia Ribeiro, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana
Summary: In this study, the effects of physical exercise in the presence of Vitamin D3 (VD3) on hemiparkinsonian rats were investigated. The results showed that exercise plus VD3 improved behavioral changes, increased dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations, and restored the expression levels of tyrosine hydroxylase (TH), dopamine transporter (DAT), and VD3 receptor (VD3R). Additionally, VD3 supplementation decreased oxidative stress, which was intensified by exercise.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Francisco Rogenio Silva Mendes, Antonio Wlisses da Silva, Maria Kueirislene Amancio Ferreira, Emanuela de Lima Reboucas, Italo Moura Barbosa, Matheus Nunes da Rocha, Walber Henrique Ferreira Ribeiro, Ramon Roseo Paula Pessoa Bezerra de Menezes, Emanuel Paula Magalhaes, Emanuelle Machado Marinho, Marcia Machado Marinho, Paulo Nogueira Bandeira, Jane Eire Silva Alencar de Menezes, Emmanuel Silva Marinho, Helcio Silva dos Santos
Summary: The prevalence of anxiety is a significant public health problem and ranks as the 24th leading cause of disability. Chalcones, a subclass of flavonoids, show anxiolytic effects by interacting with CNS receptors. The study investigates the anxiolytic effect of synthetic chalcones derived from a natural product in a zebrafish model, showing potential for GABAergic and serotoninergic neurotransmission.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Developmental Biology
Carla Larissa de Castro Vieira Carneiro, Edna Maria Camelo Chaves, Kelly Rose Tavares Neves, Marcus Davis Machado Braga, Ana Maria Sampaio Assreuy, Maria Elisabete Amaral de Moraes, Gislei Frota Aragao
Summary: This study aimed to evaluate the toxicity of glyphosate-based herbicide (GBH) on the offspring of mice during the intrauterine period. Results showed that exposure to GBH led to increased anxiety and hyperactivity in the mice offspring, as well as neuroinflammation in the prefrontal cortex. This suggests that intrauterine exposure to GBH can have detrimental effects on the nervous system.
BIRTH DEFECTS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carlos S. M. B. Filho, Ramon R. P. P. B. de Menezes, Emanuel P. Magalhaes, Yunierkis P. Castillo, Alice M. C. Martins, Damiao P. de Sousa
Summary: This study evaluated the trypanocidal activity of 13 ester compounds analogous to Piplartine and found that compound 11 showed good activity against Trypanosoma cruzi through the induction of oxidative stress and mitochondrial damage. The study suggests that compound 11 has potential for the development of new trypanocidal prototypes for researching drugs against Chagas disease.
Article
Biochemistry & Molecular Biology
Jose Ismael F. de Araujo, Natalia L. Aires, Francisco W. Q. Almeida-Neto, Marcia M. Marinho, Emanuelle M. Marinho, Emanuel Paula Magalhaes, Ramon R. P. P. B. de Menezes, Tiago L. Sampaio, Alice Maria Costa Martins, Edson H. Teixeira, Ana Rafaela Freitas Dotto, Wanderlei do Amaral, Alexandre Magno R. Teixeira, Pedro De Lima-Neto, Emmanuel S. Marinho, Helcio S. dos Santos
Summary: The study found that the triterpene CLF-1 has a good inhibitory effect on Trypanosoma cruzi and is well-absorbed in the intestine with low toxicity, making it a potential candidate for new Chagas disease treatments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)