Electrical Stimulation of the Auricular Branch Vagus Nerve Using Random and Alternating Frequencies Triggers a Rapid Onset and Pronounced Antihyperalgesia via Peripheral Annexin A1-Formyl Peptide Receptor 2/ALX Pathway in a Mouse Model of Persistent Inflammatory Pain

Decrease of IL-1β and TNF in the Spinal Cord Mediates Analgesia Produced by Ankle Joint Mobilization in Complete Freund Adjuvant-Induced Inflammation Mice Model

(2022) Carlos Minoru Omura et al.   Frontiers in Physiology

Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2–IRF pathway

(2022) Jixiang Yuan et al.   INFLAMMOPHARMACOLOGY

Electroacupuncture decreases inflammatory pain through a pro-resolving mechanism involving the peripheral annexin A1-formyl peptide receptor 2/ALX-opioid receptor pathway

(2021) Cintia Vieira et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Annexin A1 protects against cerebral ischemia–reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway

(2021) Xin Xu et al.   Journal of Neuroinflammation

Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine

(2021) Jin Cao et al.   Journal of Translational Medicine

The role of macrophage polarization and associated mechanisms in regulating the anti-inflammatory action of acupuncture: a literature review and perspectives

(2021) Jiaqi Wang et al.   Chinese Medicine

Effects of different doses of complete Freund’s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis

(2021) Ain’ Sabreena Mohd Noh et al.   PLoS One

Comparative effect of dense-and-disperse versus non-repetitive and non-sequential frequencies in electroacupuncture-induced analgesia in a rodent model of peripheral neuropathic pain

(2021) Liaw Chao et al.   Acupuncture in Medicine

Neuraxial Cytokines in Pain States

(2020) Gilson Gonçalves dos Santos et al.   Frontiers in Immunology

Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice

(2020) Jonathan Y. Y. Yap et al.   Frontiers in Neuroscience

Impaired Vagal Efficiency Predicts Auricular Neurostimulation Response in Adolescent Functional Abdominal Pain Disorders

(2020) Katja Kovacic et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Treatment of Stage 3 COVID ‐19 With Transcutaneous Auricular Vagus Nerve Stimulation Drastically Reduces Interleukin‐6 Blood Levels: A Report on Two Cases

(2020) André P. Boezaart et al.   NEUROMODULATION

Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity

(2020) Xiao Guo et al.   NEURAL PLASTICITY

ET-B receptors involvement in peripheral opioid analgesia induced by light-emitting diode photobiomodulation in male and female mice

(2020) Bruna Hoffmann de Oliveira et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Advancements of Annexin A1 in inflammation and tumorigenesis

(2019) Gang Shao et al.   OncoTargets and Therapy

Management of Patients with a Musculoskeletal Pain Condition that is Likely Chronic: Results from a National Cross Sectional Survey

(2019) Debbie Ehrmann Feldman et al.   JOURNAL OF PAIN

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management

(2019) Arden G. Vanderwall et al.   Frontiers in Immunology

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

(2018) Ru-Rong Ji et al.   ANESTHESIOLOGY

Glucantime reduces mechanical hyperalgesia in cutaneous leishmaniasis and complete Freund's adjuvant models of chronic inflammatory pain

(2018) Suelen S. da Silva et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Influence of Disease Manifestations on Health-related Quality of Life in Early Psoriatic Arthritis

(2018) Kim Wervers et al.   JOURNAL OF RHEUMATOLOGY

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations

(2018) P S Matusik et al.   LUPUS

Auricular vagus nerve stimulation enhances central serotonergic function and inhibits diabetic neuropathy development in Zucker fatty rats

(2018) Shaoyuan Li et al.   Molecular Pain

Intranasal administration of sodium dimethyldithiocarbamate induces motor deficits and dopaminergic dysfunction in mice

(2018) Josiel M. Mack et al.   NEUROTOXICOLOGY

The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review

(2018) Marijke De Couck et al.   Journal of Oncology

Electroacupuncture induces antihyperalgesic effect through endothelin-B receptor in the chronic phase of a mouse model of complex regional pain syndrome type I

(2018) Leidiane Mazzardo-Martins et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Non-invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice

(2018) Gun-Soo Hong et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Long-Term Regular Eccentric Exercise Decreases Neuropathic Pain-like Behavior and Improves Motor Functional Recovery in an Axonotmesis Mouse Model: the Role of Insulin-like Growth Factor-1

(2017) Daniel F. Martins et al.   MOLECULAR NEUROBIOLOGY

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function

(2017) Jesmond Dalli et al.   Frontiers in Immunology

Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation

(2016) Bruno Bonaz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats

(2016) Jingxi Ma et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Advanced Innovations for Pain

(2016) Tim J. Lamer et al.   MAYO CLINIC PROCEEDINGS

Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells

(2016) Peng Huang et al.   MEDIATORS OF INFLAMMATION

Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia/reperfusion rat model

(2016) Ying Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

Duration Dependent Effects of Transcranial Pulsed Current Stimulation (tPCS) Indexed by Electroencephalography

(2016) Alejandra Vasquez et al.   NEUROMODULATION

Light-emitting diode therapy reduces persistent inflammatory pain: Role of interleukin 10 and antioxidant enzymes

(2016) D.F. Martins et al.   NEUROSCIENCE

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

FPR2/ALX activation reverses LPS-induced vascular hyporeactivity in aorta and increases survival in a pneumosepsis model

(2015) Verônica Vargas Horewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part II

(2015) Hsiangkuo Yuan et al.   HEADACHE

Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial

(2015) Andreas Straube et al.   JOURNAL OF HEADACHE AND PAIN

Transcutaneous vagal nerve stimulation may elicit anti- and pro-nociceptive effects under experimentally-induced pain — A crossover placebo-controlled investigation

(2014) René Laqua et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers

(2014) Yunshu Gao et al.   BMC CANCER

Vagus nerve controls resolution and pro-resolving mediators of inflammation

(2014) Valbona Mirakaj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain

(2014) Daniel F. Martins et al.   JOURNAL OF NEUROSCIENCE RESEARCH

QEEG indexed frontal connectivity effects of transcranial pulsed current stimulation (tPCS): A sham-controlled mechanistic trial

(2014) Laura Castillo Saavedra et al.   NEUROSCIENCE LETTERS

Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis

(2014) Yaakov A. Levine et al.   PLoS One

Cognitive effects and autonomic responses to transcranial pulsed current stimulation

(2014) Leon Morales-Quezada et al.   EXPERIMENTAL BRAIN RESEARCH

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels

(2013) Deise Prehs Montrucchio et al.   PLoS One

Transcutaneous Auricular Vagus Nerve Stimulation Protects Endotoxemic Rat from Lipopolysaccharide-Induced Inflammation

(2012) Yu Xue Zhao et al.   Evidence-based Complementary and Alternative Medicine

Rethinking inflammation: neural circuits in the regulation of immunity

(2012) Peder S. Olofsson et al.   IMMUNOLOGICAL REVIEWS

Neural reflexes in inflammation and immunity

(2012) Ulf Andersson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Imaging studies in Freund's complete adjuvant model of regional polyarthritis, a model suitable for the study of pain mechanisms, in the rat

(2011) Lina Almarestani et al.   ARTHRITIS AND RHEUMATISM

Annexin 1 exerts anti-nociceptive effects after peripheral inflammatory pain through formyl-peptide-receptor-like 1 in rat dorsal root ganglion

(2011) L. Pei et al.   BRITISH JOURNAL OF ANAESTHESIA

Roles of reactive oxygen and nitrogen species in pain

(2011) Daniela Salvemini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture

(2011) Wai Chung et al.   Chinese Medicine

The chemical neuroanatomy of vagus nerve stimulation

(2010) Riccardo Ruffoli et al.   JOURNAL OF CHEMICAL NEUROANATOMY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

An investigation of the development of analgesic tolerance to TENS in humans

(2010) Richard E. Liebano et al.   PAIN

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Cholinergic control of inflammation

(2009) M. Rosas-Ballina et al.   JOURNAL OF INTERNAL MEDICINE

Mycobacteria Attenuate Nociceptive Responses by Formyl Peptide Receptor Triggered Opioid Peptide Release from Neutrophils

(2009) Heike L. Rittner et al.   PLoS Pathogens

Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory

(2008) Rui D.S. Prediger et al.   JOURNAL OF ETHNOPHARMACOLOGY

Blockade of NMDA Receptors Prevents Analgesic Tolerance to Repeated Transcutaneous Electrical Nerve Stimulation (TENS) in Rats

(2007) Priyanka M. Hingne et al.   JOURNAL OF PAIN