Article
Environmental Sciences
Mamdouh M. T. Eassawy, Asmaa A. Salem, Amel F. M. Ismail
Summary: The study demonstrates that hepatotoxicity induced by APAP overdose or gamma-irradiation can be alleviated with curcumin pretreatment. Curcumin shows hepatoprotective effects by regulating gene expression related to therapeutic targets.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Biomedical
Mei Zhang, Xiaolin Zhang, Taoran Tian, Qi Zhang, Yuting Wen, Junyao Zhu, Dexuan Xiao, Weitong Cui, Yunfeng Lin
Summary: Gouty arthritis is a common inflammatory arthritis, and controlling inflammation is crucial for prevention. Scientists have synthesized a new material called Cur-TFNAs to enhance the effectiveness and bioavailability of curcumin, a natural anti-inflammatory drug. Cur-TFNAs showed better anti-inflammatory effects in in vivo and in vitro experiments compared with free curcumin.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Yan-Qing Xie, Jing-Yao Huang, Yun-Xiu Chen, Qian Zhou, Qi-Xiu Zhou, Zhu-Ya Yang, Shi-Kui Xu, Wen-Hong Tan, Lu Liu
Summary: This study investigates the metabolites in the bark and leaves of Streblus indicus for their anti-inflammatory and analgesic effects. The results provide scientific evidence for the traditional use of S. indicus and offer a theoretical foundation for the development of new anti-inflammatory and analgesic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.
Article
Biochemistry & Molecular Biology
Sewoong Lee, Jain Ha, Jiyoung Park, Eunjeong Kang, Sung-Hyun Jeon, Sang Beom Han, Sri Ningsih, Jin Hyub Paik, Sayeon Cho
Summary: The study examined the antioxidant and anti-inflammatory mechanisms of methanol extracts of Bischofia javanica leaves, finding that MBJ inhibits inflammatory responses by suppressing NF-κ B and MAPK pathways, inducing Nrf2 nuclear translocation. The extract also demonstrated antioxidant and anti-inflammatory effects in an acute hepatitis mouse model, suggesting its potential for treating various pathologies with inflammatory and redox imbalances.
Article
Nutrition & Dietetics
Xiaoping Ma, Samuel Kumi Okyere, Liwen Hu, Juan Wen, Zhihua Ren, Junliang Deng, Yanchun Hu
Summary: CCGA isolated from Ageratina adenophora was found to effectively reduce the inflammatory response induced by LPS and inhibit the expression of inflammatory mediators and related proteins. This finding suggests that CCGA has the potential for the treatment of inflammation-related diseases.
Article
Biochemistry & Molecular Biology
Federica Tonolo, Alessandra Folda, Valeria Scalcon, Oriano Marin, Alberto Bindoli, Maria Pia Rigobello
Summary: This study found that the bioactive peptides K-8-K and S-10-S, derived from milk and soy, have both antioxidant and anti-inflammatory effects in human cells. They exert antioxidant effects through activation of the Keap1/Nrf2 pathway and exert anti-inflammatory effects by inhibiting the NF-κB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Abeer A. Al-Masri, Fuad Ameen
Summary: Banana is an important fruit crop worldwide. In this study, an anthocyanin-rich extract from banana bract (BBA) was prepared and characterized. BBA showed antioxidant and anti-inflammatory activity in LPS-stimulated macrophage-like cells. The presence of phenolic compounds, flavonoids, and anthocyanin in BBA was identified. BBA increased endogenous antioxidants and inhibited the nuclear translocation of NF-kappaB under LPS-stimulated conditions, indicating its potential as an anti-inflammatory agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Afnan, Ammara Saleem, Muhammad Furqan Akhtar, Ali Sharif, Bushra Akhtar, Rida Siddique, Ghulam Md Ashraf, Badrah S. Alghamdi, Saif A. Alharthy
Summary: Phenolic acids are a prevalent class of bioactive chemicals found in plants, with various bioactivities such as anticancer, anti-inflammatory, and cardioprotective effects. Their strong antioxidant properties and modulation of oxidative stress and signal transduction pathways contribute to their therapeutic potential. Further research is needed to fully understand their mechanisms of action and evaluate their efficacy in human disease therapy.
Review
Pharmacology & Pharmacy
Yu Xian Goh, Juriyati Jalil, Kok Wai Lam, Khairana Husain, Chandini Menon Premakumar
Summary: Non-resolving inflammation is a major trigger in various diseases, and patients are seeking natural compounds, such as genistein, as alternative medicine due to the undesirable effects of anti-inflammatory drugs. Previous studies have shown that genistein has strong anti-inflammatory activities by inhibiting various signaling pathways and mediators. However, evidence for its pharmacological effects is still lacking, and further studies are needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Biomaterials
Chunxian Piao, Chuanyu Zhuang, Minji Kang, Jihun Oh, Minhyung Lee
Summary: This study developed glycyrrhizic acid (GA) micelles as a carrier for curcumin (Cur) to treat acute lung injury (ALI). Results showed that the GA-Cur nanoparticles efficiently delivered GA and Cur, reduced pro-inflammatory cytokines, inhibited nuclear translocation, and induced heme oxygenase-1. In vivo experiments demonstrated that GA-Cur reduced inflammation, hemolysis, and monocyte infiltration in ALI mouse models. The study suggests that GA-Cur nanoparticles are a promising treatment for ALI.
BIOMATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
So-Yeon Kim, Sang-Deok Han, Minju Kim, Tamanna Jahan Mony, Eun-Seok Lee, Kyeong-Min Kim, Seung-Hyuk Choi, Sun Hee Hong, Ji Woong Choi, Se Jin Park
Summary: The study demonstrated that Mentha arvensis essential oil (MAEO) exerts anti-inflammatory effects in an atopic dermatitis (AD) model by inhibiting the ERK/NF-kappa B signaling pathway.
Article
Cell & Tissue Engineering
Qin Junjun, Li Mingdong
Summary: The study demonstrated that curcumin has a significant inhibitory effect on rheumatoid arthritis, reducing paw swelling and regulating inflammatory factors and protein expressions. Its effectiveness is dose-dependent and weaker than that of dexamethasone in the CIA rat model. Curcumin exerts its effects by transcriptional regulation of the IKK-alpha/-beta/NF-kappa B pathway.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Chemistry, Medicinal
Mostafa M. Ghorab, Fatma A. Ragab, Helmy Heiba, Marwa G. El-Gazzar, Mostafa G. M. El-Gazzar
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Organic
Marwa G. El-Gazzar, Hala M. Aly
CURRENT ORGANIC SYNTHESIS
(2018)
Article
Biochemistry & Molecular Biology
Marwa G. El-Gazzar, Rania M. El-Hazek, Nashwa H. Zaher, Mona A. El-Ghazaly
BIOORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Shaymaa G. Hammad, Marwa G. El-Gazzar, Nader S. Abutaleb, Daoyi Li, Isabell Ramming, Aditya Shekhar, Mohammad Abdel-Halim, Eman Z. Elrazaz, Mohamed N. Seleem, Ursula Bilitewski, Khaled A. M. Abouzid, Ebaa M. El-Hossary
BIOORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Sawsan M. Elsonbaty, Amel F. M. Ismail
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Chemistry, Medicinal
Reham M. M. El-Hazek, Walaa A. El-Sabbagh, Rania M. El-Hazek, Marwa G. El-Gazzar
ARCHIV DER PHARMAZIE
(2020)
Article
Environmental Sciences
Mamdouh M. T. Eassawy, Asmaa A. Salem, Amel F. M. Ismail
Summary: The study demonstrates that hepatotoxicity induced by APAP overdose or gamma-irradiation can be alleviated with curcumin pretreatment. Curcumin shows hepatoprotective effects by regulating gene expression related to therapeutic targets.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Reham M. El-Hazek, Nora M. Elkenawy, Nashwa H. Zaher, Marwa G. El-Gazzar
Summary: This study successfully synthesized 11 novel triazole derivatives using water as a green solvent, and found that one of the derivatives, compound 6, exhibited promising antimicrobial activity against both fungal and bacterial strains, as well as inhibitory effects on specific enzymes, without displaying cytotoxicity.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Medicinal
Nashwa H. Zaher, Marwa M. El-Sheikh, Rania M. El-Hazek, Marwa G. El-Gazzar, Reham M. M. El-Hazek
Summary: The present study synthesized twelve thiadiazole derivatives incorporating different amino acid moieties, which have the potential of being anti-inflammatory compounds with low cardiovascular risks. Compound 5 was identified as the most potent anti-inflammatory agent with the least cardiotoxicity effect.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Medicinal
Mostafa G. M. El-Gazzar, Marwa G. El-Gazzar, Mostafa M. Ghorab
Summary: New quinazolinones with acetamide linkers were synthesized as potential anti-breast cancer agents. In vitro cytotoxic evaluation identified 1,3-benzodioxole (5d) as the most potent compound with good inhibitory activity on CDK4/6. Compound 5d arrested the cell cycle, induced apoptosis, and showed good radiosensitizing activity when combined with γ-radiation in breast cancer cells. This study introduces quinazolinone scaffolds as new CDK4/6 inhibitors for breast cancer treatment.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Amel F. M. Ismail, Asmaa A. Salem, Mamdouh M. T. Eassawy
Summary: This study investigated the protective response of rutin against kidney injury induced by malathion and gamma-irradiation in rats. The results showed that rutin treatment regulated various biochemical parameters, oxidative stress, antioxidant status, and inflammatory responses in the kidney tissues. It also modulated the activity of enzymes, gene expressions, and protein expressions related to renal function. Histopathological examinations confirmed these findings.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Mamdouh M. T. Eassawy, Amel F. M. Ismail
Summary: CLE and/or ALE demonstrated nephroprotection against CCl4/Rad co-toxicity mediated by down-regulation of renal Wnt/beta-catenin protein expressions.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Hayam M. Sayed, Mahmoud M. Said, Nadia Y. S. Morcos, Mona A. El Gawish, Amel F. M. Ismail
Summary: ZnO-CA NPs demonstrate anticancer activity both in vitro and in vivo, which is enhanced by combination with gamma-irradiation.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Toxicology
Asmaa A. Salem, Amel F. M. Ismail
Summary: Chronic kidney disease is a prevalent health issue, especially in developing countries. This study investigated the protective mechanism of Spirulina platensis against nephrotoxicity induced by gamma-irradiation and thioacetamide in rats. Spirulina administration showed a nephroprotective impact by regulating key factors to alleviate kidney damage.
TOXICOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
