Article
Biochemistry & Molecular Biology
Abayomi S. Faponle, Anupom Roy, Ayodeji A. Adelegan, James W. Gauld
Summary: Cytochrome P450s (P450) are important enzymes with potential for oxy-functionalization of organic molecules, and recent research on a new member of the CYP116B family, P450-TT, suggests that it can control the entry of substrates to its active site through an elaborate substrate channel.
Article
Nutrition & Dietetics
Vanessa Rosa Retamoso, Fernanda Barbisan, Graziele Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Viera dos Santos, Lyana Berro Feijoo, Matias Nunes Frizzo, Ivana Beatrice Manica da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli
Summary: This study evaluates the effect of the BsmI single nucleotide polymorphism (SNP) of the VDR gene on the expression of VDR, SOD2, and CYP24A1 genes in individuals with low serum vitamin D levels. The results show that the BsmI SNP of the VDR gene leads to overexpression of the CYP24A1 gene and low expression of the SOD2 gene. Therefore, the BsmI SNP of the VDR gene can modulate gene expression without interfering with serum vitamin D levels.
Article
Biochemistry & Molecular Biology
Juan Huang, Qin Xu, Zhuo Liu, Nitin Jain, Madhusudan Tyagi, Dong-Qing Wei, Liang Hong
Summary: This study found that the high density of salt bridges in CYP450 proteins reduces structural flexibility, affecting substrate selection and catalytic activity. By making slight chemical changes, the CYP450 superfamily can regulate the structural flexibility of its member proteins to differentiate substrate specificities.
Article
Biochemistry & Molecular Biology
Tianxiang Xiao, Kai Lu
Summary: The common cutworm, Spodoptera litura, has developed resistance to commonly used insecticides. Two P450 enzymes, CYP6AE43 and CYP6AE48, play a crucial role in detoxifying pyrethroids and promoting resistance development in S. litura.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Hang Yu, Meiqi Song, Keqi Hu, Yujian Wang, Ruifang Fan, Zongying Yang, Hansruedi Glatt, Albert Braeuning, Yungang Liu
Summary: Bisphenol compounds may increase the genotoxic effects of metabolically activated carcinogens by modulating the expression of nuclear receptors and xenobiotic-metabolizing enzymes in human liver cancer cells, potentially aggravating chromosome damage caused by impactful carcinogens in human cells.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jakub Hofman, Dimitrios Vagiannis, Si Chen, Lei Guo
Summary: Metabolic deactivation by cytochrome P450 (CYP) might be a significant mechanism of resistance to docetaxel, while the resistance to paclitaxel and vincristine is not influenced by CYP enzymes. These findings could provide valuable insights for future in vivo studies investigating intratumoural metabolism-based drug resistance.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Medicinal
Natthaporn Kuendee, Alisa Naladta, Thitianan Kulsirirat, Thunyatorn Yimsoo, Werayut Yingmema, Kanoktip Pansuksan, Korbtham Sathirakul, Sophida Sukprasert
Summary: This study investigated the effects of Lysiphyllum strychnifolium extracts on the gene expression of drug-metabolizing enzymes in rats. The results showed that different doses of the extracts can modulate the mRNA expression levels of clinically relevant CYP genes, and gender also plays a role in gene expression. These findings provide valuable information for the practical use of Lysiphyllum strychnifolium extracts in humans.
Article
Pharmacology & Pharmacy
Fabio Bachmann, Urs Duthaler, Stephan Krahenbuhl
Summary: This study investigated the effect of deglucuronidation on the plasma concentration of the constituents of the Basel phenotyping cocktail. The results showed that deglucuronidation of plasma samples improves the stability of phenotyping results and is necessary to reliably detect CYP induction.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ragini D. D. Singh, Avadhesh Avadhesh, Gaurav Sharma, Sagar Dholariya, Rima B. B. Shah, Bela Goyal, Subash Chandra Gupta
Summary: Targeted cancer therapy using CYP as drug target has shown promise, but there are still challenges including drug resistance and limited therapeutic index. Recent advances in molecular tools and structure-activity relationship understanding have helped in the development of CYP-based drugs with better efficacy. Future directions involve the development of more selective tools to understand molecular alterations and develop specific CYP inhibitors/inducers.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Engineering, Environmental
Hang Yu, Yungang Liu
Summary: Bisphenol compounds are significant environmental pollutants and disruptors of the endocrine system. This study suggests that combined and extended exposure to these compounds can enhance their genotoxicity, specifically promoting the formation of aneuploid chromosomes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Toxicology
Slobodan P. Rendic, F. Peter Guengerich
Summary: This overview discusses the metabolic activation of various compounds by cytochrome P450 enzymes, with a focus on bioactivation reactions. The study identifies a higher level of activation for general chemicals, drugs, and natural products compared to physiological compounds. Enzymes such as P450 3A4, 1A2, 2E1, and 1A1 are highlighted for their roles in catalyzing the formation of activated metabolites from different compound groups.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Plant Sciences
Pramesti Istiandari, Shuhei Yasumoto, Pisanee Srisawat, Keita Tamura, Ayaka Chikugo, Hideyuki Suzuki, Hikaru Seki, Ery Odette Fukushima, Toshiya Muranaka
Summary: Research reveals that different plant CPR classes have varied effects on triterpenoid production when co-expressed with different CYP classes. Co-expression of these genes in yeast can lead to higher yields and more valuable compounds.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Xu Wang, Jingjing Fa, Yuanjin Zhang, Shengbo Huang, Jie Liu, Junqing Gao, Lina Xing, Zongjun Liu, Xin Wang
Summary: There is a potential interaction between Danshen tablet and rivaroxaban as the former inhibits the metabolism of the latter. This may be due to the strong inhibitory effects of Danshen tablet's components, particularly dihydrotanshinone I, on CYP enzymes. Therefore, drug monitoring and dosage adjustment are necessary when Danshen tablet and rivaroxaban are used simultaneously in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Diana Maria Campodonico, Pablo Zubiaur, Paula Soria-Chacartegui, Ana Casajus, Gonzalo Villapalos-Garcia, Marcos Navares-Gomez, Antia Gomez-Fernandez, Raul Parra-Garces, Gina Mejia-Abril, Manuel Roman, Samuel Martin-Vilchez, Dolores Ochoa, Francisco Abad-Santos
Summary: This study aimed to investigate the impact of CYP3A4 and CYP2C8 variants, along with other pharmacogenes, on cinitapride pharmacokinetics and safety, as well as evaluate the effect of CYP2C8 alleles on enzyme function. CYP2C8*3 and *4 alleles may be used to infer pharmacogenetic phenotypes.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Plant Sciences
Pramesti Istiandari, Shuhei Yasumoto, Hikaru Seki, Ery Odette Fukushima, Toshiya Muranaka
Summary: This study reveals that CPR classes I and II play different roles in triterpenoid biosynthesis in L. japonicus, with CPR class I potentially playing a crucial role in plant basal metabolism.
FRONTIERS IN PLANT SCIENCE
(2023)