Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death

A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid beta-induced neuronal cell death at concentrations of 12.5-25 nM, but did not inhibit amyloid beta production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid beta-induced neuronal cell death without affecting amyloid b production. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.