The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro -to- In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research

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Title
The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro -to- In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research
Authors
Keywords
ADME, clearance, disposition, distribution, hepatocytes, IVIVE, partition coefficients, pharmacokinetics, pharmacodynamics, PKPD
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 105, Issue 2, Pages 497-508
Publisher
Elsevier BV
Online
2015-07-15
DOI
10.1002/jps.24571

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