Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro–In Vivo Discrepancy in Its Drug Interaction Potential in Rats

Title
Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro–In Vivo Discrepancy in Its Drug Interaction Potential in Rats
Authors
Keywords
drug interactions, in vitro, /, in vivo, correlations, pharmacokinetics, protein binding, transporters, CYP enzymes, hepatocytes, organic anion-transporting polypeptide transporters, multidrug resistance transporters, solute transporters
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 105, Issue 7, Pages 2231-2239
Publisher
Elsevier BV
Online
2016-06-12
DOI
10.1016/j.xphs.2016.04.025

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