Review
Oncology
Daisy Wai-Ka Chan, Horace Cheuk-Wai Choi, Victor Ho-Fun Lee
Summary: This study conducted a systematic review and meta-analysis to investigate the treatment-related adverse events (trAEs) of combined epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI) and immune checkpoint inhibitor (ICI) in advanced non-small cell lung cancer (NSCLC). The results demonstrated a higher incidence of grade >= 3 trAEs in combination TKI and ICI, particularly in skin, gastrointestinal tract, and interstitial lung diseases. However, the interpretation of these results should be cautious due to the limited number of studies included in this meta-analysis.
Review
Oncology
Nathaniel Wiest, Umair Majeed, Karan Seegobin, Yujie Zhao, Yanyan Lou, Rami Manochakian
Summary: In the past decade, the treatment of advanced EGFRm NSCLC has seen rapid changes with innovations in oncogene-directed therapy and immune checkpoint inhibitors. Newer-generation TKIs have shown unparalleled survival benefit for EGFRm NSCLC patients. However, the application of ICI therapy to these patients is controversial, with early studies showing inferiority to other treatment methods.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Carolin Selenz, Anik Compes, Marieke Nill, Sven Borchmann, Margarete Odenthal, Alexandra Florin, Johannes Braegelmann, Reinhard Buettner, Lydia Meder, Roland T. Ullrich
Summary: EGFR inhibition promotes immune cell infiltration in the tumour microenvironment and enhances response to immune checkpoint inhibitors in EGFR-driven lung cancer.
Article
Immunology
Qian Chen, Xiaoling Shang, Ni Liu, Xinchun Ma, Wenfei Han, Xiuwen Wang, Yanguo Liu
Summary: The study found that patients with major EGFR mutations had poorer responses to ICIs compared to patients with rare EGFR mutations. EGFR-mutated patients with lower PD-L1 expression tended to have longer overall survival after receiving ICIs. Heavily treated patients with more than three prior lines of therapy had significantly shorter progression-free survival and overall survival, as well as a lower objective response rate.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Chunyan Shi, Yan Wang, Jianxin Xue, Xiaojuan Zhou
Summary: ICIs are effective in NSCLC patients regardless of PD-L1 expression, and combination with chemotherapy can improve efficacy. Patients with rare mutations show better response to ICIs in terms of progression-free survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Dan Yan, Justus M. Huelse, Dmitri Kireev, Zikang Tan, Luxiao Chen, Subir Goyal, Xiaodong Wang, Stephen Frye, Madhusmita Behera, Frank Schneider, Suresh S. Ramalingam, Taofeek Owonikoko, H. Shelton Earp, Deborah DeRyckere, Douglas K. Graham
Summary: Acquired resistance is inevitable in non-small cell lung cancers (NSCLCs) treated with osimertinib (OSI). Activation of MERTK is associated with OSI resistance and inhibition of MERTK kinase can resensitize resistant cells to OSI.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan
Summary: PKC delta is identified as a critical factor in the non-inflamed tumor microenvironment (TME) of EGFR-mutated lung cancer. Inhibition of PKC delta enhances the infiltration of immune cells into tumors and increases the sensitivity of tumors to immune checkpoint blockade therapy.
Article
Oncology
Zichun Li, Xuanye Zhang, Yuhong Wang, Zhixin Yu, Chunlong Yang, Yixin Zhou, Shaodong Hong
Summary: A comparative analysis suggests that osimertinib is a more suitable adjuvant therapy than immunotherapy for completely resected EGFR-mutant NSCLC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Yang Fu, Yue Zheng, Pei-Pei Wang, Zhen-Yu Ding
Summary: Small cell lung cancer (SCLC) is a fatal disease with poor prognosis, traditionally treated with etoposide platinum doublet chemotherapy. Immunotherapies like atezolizumab and durvalumab have shown survival benefits but also come with adverse events, requiring cautious clinical use.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Marcus Skribek, Konstantinos Rounis, Georgios Tsakonas, Simon Ekman
Summary: The emergence of tyrosine kinase inhibitors and immune checkpoint inhibitors has improved survival rates for non-small cell lung cancer patients, but also presents new challenges in terms of managing the unique toxicity profiles of these drugs.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kuo-Hsuan Hsu, Jeng-Sen Tseng, Tsung-Ying Yang, Kun-Chieh Chen, Kang-Yi Su, Sung-Liang Yu, Jeremy J. W. Chen, Yen-Hsiang Huang, Gee-Chen Chang
Summary: Strong expressions of PD-L1 in treatment naive advanced EGFR-mutant NSCLC patients were associated with poor prognoses in those undergoing treatment with osimertinib as first-line therapy.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Longhui Li, Yangyueying Liang, Minghui Yu, Lu Zhao, Qingyun Mei, Yongchao Yu, Na Wang, Dou Zhang, Ziwei Wang, Yingjie Jia, Fanming Kong
Summary: Small cell lung cancer (SCLC) is one of the most aggressive neuroendocrine tumors with a disappointing prognosis. Although it initially responds well to chemotherapy, most patients experience recurrence and poor survival. The application of ICIs in SCLC is still necessary to explore since it broke the treatment deadlock.
Review
Oncology
Ningning Yan, Sanxing Guo, Huixian Zhang, Ziheng Zhang, Shujing Shen, Xingya Li
Summary: This review summarizes the characteristics and challenges of BRAF mutations in NSCLC, as well as the treatment strategies and resistance mechanisms of BRAF-targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kazuya Nishii, Kadoaki Ohashi, Shuta Tomida, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Jun Nishimura, Hisao Higo, Hiromi Watanabe, Hirohisa Kano, Chihiro Ando, Go Makimoto, Kiichiro Ninomiya, Yuka Kato, Toshio Kubo, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Shinichi Toyooka, Heiichiro Udono, Yoshinobu Maeda, Katsuyuki Kiura
Summary: EGFR-mutant NSCLC has a noninflamed tumor microenvironment with weak response to immune-checkpoint inhibitors. EGFR-tyrosine kinase inhibitor can induce CD8+ T-cell responses, which are further enhanced by the dual blockade of PD-1 and VEGFR2. These findings could aid in developing alternative immunotherapy strategies for patients with driver mutations and a noninflamed tumor microenvironment.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Yanan Cui, Xinyin Liu, Yuemin Wu, Xiao Liang, Jiali Dai, Zhihong Zhang, Renhua Guo
Summary: Immune checkpoint inhibitors have limited efficacy in non-small cell lung cancer patients, and there is a need for reliable predictive markers. This study identified AHNAK2 mutation as a potential biomarker for predicting favorable response to ICI treatment in NSCLC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physics, Multidisciplinary
Liang Qiao, Cheng-Fa Tu, Wei Wu, Wen-Biao Wang, Sheng-Yu Yang, Sun Zhe, Peng Wu, Jin-Bo Yang, Chang-Sheng Wang, Tao Wang, Fa-Shen Li
Summary: Rare-earth and 3d transition metal intermetallic complexes with core-shell structures, such as Y2Co17@SiO2, are effective microwave absorbing materials due to their high magnetizations and natural resonance in the GHz range. In this study, Y2Co17 alloy was synthesized and coated with SiO2 to form core-shell structures. The magnetic and electromagnetic properties of Y2Co17@SiO2/PU at different volume fractions were investigated and showed strong reflection loss values and excellent microwave absorption properties. The enhancement in microwave absorption performance was attributed to the balance between permeability and permittivity of the absorber.
Article
Clinical Neurology
Xianfeng Xia, Min Li, Renxian Wei, Jin Li, Yulin Lei, Meikui Zhang
Summary: Cerebral ischemia leads to interrupted cerebral blood flow, resulting in limited oxygen and glucose supply. This triggers a cascade of pathological events, eventually leading to neuronal death. Hirudin, a specific inhibitor of thrombin, has been shown to have beneficial effects in ischemic stroke by reducing oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Jiaxin Zhang, Lili Li, Yu Miao, Xiaojing Liu, Haitao Sun, Meiqian Jiang, Xiaoli Li, Zhen Li, Cong Liu, Baohua Liu, Xingzhi Xu, Qinhong Cao, Wenya Hou, Chunlai Chen, Huiqiang Lou
Summary: In addition to entrapping sister chromatids, cohesin also drives other high-order chromosomal structural dynamics such as looping, compartmentalization, and condensation. ESCO2 acetylates a specific subset of cohesin to establish cohesion between nascent sister chromatids. The precise mechanism of this process is still unknown. This study reveals that GSK3 family kinases provide higher hierarchical control through an ESCO2 regulator, CRL4(MMS22L), by phosphorylating Thr105 in MMS22L and promoting the dimerization of CRL4(MMS22L) and ESCO2 during S phase. This research helps understand the symmetric control of cohesion establishment in eukaryotes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Xiaolin Wei, Theodoros Michelakos, Qian He, Xianxing Wang, Yu Chen, Filippos Kontos, Huaizhi Wang, Xiangde Liu, Hui Liu, Wenjing Zheng, Soldano Ferrone, Yun Zhang, Cristina R. Ferrone, Xiaowu Li, Lei Cai
Summary: This study evaluated the potential association of tumor cell metabolism and immune cell tumor infiltration with the clinical course of hepatocellular carcinoma (HCC). The results showed that tumor metabolism plays a prognostic role and correlates with immune cell infiltration in HCC. M0 macrophages and CD8(+) T cells may be promising prognostic biomarkers for HCC.
Article
Optics
Jinliang Han, Jun Zhang, Xiaonan Shan, Hangyu Peng, Yawei Zhang, Li Qin, Lijun Wang
Summary: We present a novel external cavity feedback structure based on a double-layer laser diode array with volume Bragg grating (VBG). The resulting diode laser pumping source exhibits a high-power and ultra-narrow linewidth, with a central wavelength of 811.292 nm, spectral linewidth of 0.052 nm, and output power exceeding 100 W. The tunability of the central wavelength, covering the Kr* and Ar* absorption spectra, is achieved by controlling the temperature of VBG. This is the first report of an ultra-narrow linewidth diode laser that can pump two metastable rare gases.
Article
Dentistry, Oral Surgery & Medicine
Yingying Zhang, Yiping Huang
Summary: Differentially expressed lncRNAs, miRNAs, and mRNAs associated with cementogenic differentiation of cementoblasts were identified and analyzed. The study revealed significant alterations in the expressions of lncRNAs, miRNAs, and mRNAs in cementoblasts after cementogenesis.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Li Chen, Siwei Xia, Feixia Wang, Yuanyuan Zhou, Shuqi Wang, Ting Yang, Yang Li, Min Xu, Ya Zhou, Desong Kong, Zili Zhang, Jiangjuan Shao, Xuefen Xu, Feng Zhang, Shizhong Zheng
Summary: The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis were investigated. Dysregulation of liver clock genes, especially NR1D1, was observed in mice with carbon tetrachloride-induced liver fibrosis. Disruption of the circadian clock exacerbated liver fibrosis, while NR1D1 deficiency increased sensitivity to liver fibrosis. NR1D1 was primarily degraded by N6-methyladenosine (m6A) methylation, leading to weakened mitochondrial fission function and increased mitochondrial DNA release in hepatic stellate cells. Activation of the cGAS pathway further stimulated liver fibrosis progression. Overexpression of NR1D1 restored phosphorylation of DRP1S616 and inhibited the cGAS pathway, resulting in improved liver fibrosis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yan Huang, Liwei Pan, Yanling Chang, Xiaoqin Liang, Ping Hou, Chenyang Ren, Weifeng Xu, Ruiyun Yang, Jun Li, Buming Liu
Summary: Twelve undescribed megastigmane glycosides, streilicifolosides A-L, were isolated from the leaves of Streblus ilicifolius. Two of these compounds, streilicifoloside E and platanionoside D, showed potent anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Xia Yang, Yang Wang, Tian-Xia Liu, Qi Liu, Jing Liu, Tian-Feng Lu, Rui-Xue Yang, Feng-Xian Guo, Yin-Zheng Wang
Summary: There is a correlation between floral symmetry, floral orientation, and nectar guide patterning. The dorsoventrally asymmetric expression of CYCLOIDEA (CYC)-like genes is responsible for floral zygomorphy. This study found that CpCYC1 and CpCYC2 genes have multiple roles in controlling floral symmetry, floral orientation, and nectar guide patterning in Chirita pumila.
Article
Plant Sciences
Jiao Deng, Mengyue Su, Xinyi Zhang, Xuelian Liu, Rebecca Njeri Damaris, Shiyou Lv, Pingfang Yang
Summary: A famous cultivar of lotus flower called 'Da Sajin' with red and white bicolor petals was studied to understand the mechanism behind its picotee bicolor pattern. Metabolomics and proteomics analyses revealed that the failure of anthocyanidin glycosylation in the white part of the petals was caused by a defect in the accumulation of anthocyanidin 3-O-glucosyltransferases (UFGTs). This defect was not due to transcription, but rather degradation of the UFGTs. The study also discovered a novel mechanism involving protein accumulation regulation in anthocyanin biosynthesis, which contributes to the formation of the picotee bicolor pattern in lotus flowers.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Oncology
Kristina R. Dahlstrom, Andrew G. Sikora, Yanhong Liu, Chia-Chi Chang, Peng Wei, Erich M. Sturgis, Guojun Li
Summary: This study aims to characterize the oral microbiota among middle-aged men and identify differences between men with a prevalent oral high-risk HPV infection and those without. 16S rRNA sequencing was used to characterize the oral microbiota and cobas HPV Test was used to detect oral high-risk HPV types. The results showed significant differences in the oral microbiota composition between men with and without a prevalent oral high-risk HPV infection.
Article
Computer Science, Artificial Intelligence
Jing Liu, Yang Liu, Wei Zhu, Xiaoguang Zhu, Liang Song
Summary: Transportation activity recognition (TAR) is crucial for intelligent transportation applications. This study proposes a novel parallel model, DSTRR, which combines automatic learning of statistical, spatial, and temporal features to achieve a robust representation.
PATTERN RECOGNITION
(2023)
Article
Plant Sciences
Wen Gao, Yichang Zhao, Lin Guo, Yikun Wang, Hui Gong, Bikui Zhang, Miao Yan
Summary: This study compared the efficacy of different glycyrrhizic acid preparations in the treatment of chronic hepatitis B using network meta-analysis. It found that the combination of glycyrrhizic acid and entecavir was more effective than entecavir monotherapy. MgIGI and CGI showed significant effects on liver function recovery, with MgIGI being the best choice among all glycyrrhizic acid preparations.
Article
Plant Sciences
Mao Yang, Shubei Wan, Jun Chen, Wenjing Chen, Yangming Wang, Weiyan Li, Meihong Wang, Rongzhan Guan
Summary: In this study, a cytochrome P-450-like gene BnaC08g34840D (BnCDE1) was isolated from a chlorophyll-deficient mutant of Brassica napus. The mutation in BnCDE1 altered leaf color and affected the balance between heme and chlorophyll biosynthesis pathways. The CRISPR/Cas9 gene-editing method was used to restore normal leaf coloration in the mutant, providing insights into the regulation of chlorophyll biosynthesis.
Article
Plant Sciences
Jun Wei, Xing-ting Wu, Xiao-ying Li, Wim J. J. Soppe, Hong Cao, Yong-xiu Liu
Summary: The study found that Taetr1-1 can enhance seed dormancy and ethylene insensitivity in wheat, indicating a conserved role of ETR1 in regulating seed dormancy. This research contributes to our understanding of the molecular basis for pre-harvest sprouting resistance in wheat.