Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Non-Random Pattern of Integration for Epstein-Barr Virus with Preference for Gene-Poor Genomic Chromosomal Regions into the Genome of Burkitt Lymphoma Cell Lines

(2022) Snjezana Janjetovic et al.   Viruses-Basel

Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy

(2022) Lipei Shao et al.   Scientific Reports

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

(2021) Nisha B. Nagarsheth et al.   NATURE MEDICINE

Mechanisms driving neutrophil-induced T-cell immunoparalysis in ovarian cancer

(2021) Tiffany R Emmons et al.   Cancer Immunology Research

Characterization of HLH-Like Manifestations as a CRS Variant in Patients Receiving CD22 CAR T-Cells

(2021) Daniel A Lichtenstein et al.   BLOOD

HPV16-LINC00393 Integration Alters Local 3D Genome Architecture in Cervical Cancer Cells

(2021) Xinxin Xu et al.   Frontiers in Cellular and Infection Microbiology

Genome-Wide Profiling Reveals HPV Integration Pattern and Activated Carcinogenic Pathways in Penile Squamous Cell Carcinoma

(2021) Kang-Bo Huang et al.   Cancers

Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels

(2020) Wenliang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

(2020) Alyssa Sheih et al.   Nature Communications

Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

(2020) Norris Lam et al.   Nature Communications

An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses

(2020) Daria W. Wells et al.   BMC GENOMICS

CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial

(2020) Nirali N. Shah et al.   JOURNAL OF CLINICAL ONCOLOGY

Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products

(2020) Alex Lu et al.   Journal of Translational Medicine

Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7

(2020) Christina Amatya et al.   MOLECULAR THERAPY

Design and Assessment of Novel Anti-CD30 CARs with Human Antigen-recognition Domains

(2020) Stephanie Choi et al.   HUMAN GENE THERAPY

Genome-wide integration site detection using Cas9 enriched amplification-free long-range sequencing

(2020) Joost van Haasteren et al.   NUCLEIC ACIDS RESEARCH

CD19 CAR T cell product and disease attributes predict leukemia remission durability

(2019) Olivia C. Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

(2019) Christopher L. Nobles et al.   JOURNAL OF CLINICAL INVESTIGATION

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

(2018) Kenneth Cornetta et al.   MOLECULAR THERAPY

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

(2018) Joseph A. Fraietta et al.   NATURE

Screening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience

(2018) Kenneth Cornetta et al.   Molecular Therapy-Methods & Clinical Development

Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites

(2018) Richard T. Timms et al.   Nature Protocols

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

(2017) Eric Sherman et al.   Molecular Therapy-Methods & Clinical Development

Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL

(2016) X. Wang et al.   BLOOD

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

(2016) Cameron J. Turtle et al.   JOURNAL OF CLINICAL INVESTIGATION

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration

(2014) S. S. De Ravin et al.   JOURNAL OF VIROLOGY

MLV integration site selection is driven by strong enhancers and active promoters

(2014) Matthew C. LaFave et al.   NUCLEIC ACIDS RESEARCH

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Lentiviral Vectors in Gene Therapy: Their Current Status and Future Potential

(2010) David Escors et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma

(2010) Martine Peter et al.   JOURNAL OF PATHOLOGY

The Majority of Viral-Cellular Fusion Transcripts in Cervical Carcinomas Cotranscribe Cellular Sequences of Known or Predicted Genes

(2008) I. Kraus et al.   CANCER RESEARCH

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION