Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity

ASK1 suppresses NK cell‐mediated intravascular tumor cell clearance in lung metastasis

(2021) Makoto Fujimoto et al.   CANCER SCIENCE

Recent Developments in PROTAC‐Mediated Protein Degradation: From Bench to Clinic

(2021) Zhenyi Hu et al.   CHEMBIOCHEM

Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)

(2021) Po-Han Chen et al.   ACS Chemical Biology

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

(2021) Satomi Imaide et al.   Nature Chemical Biology

ASK1 inhibition: a therapeutic strategy with multi-system benefits

(2020) Jacqueline M. Ogier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Structure and function of the co-chaperone protein phosphatase 5 in cancer

(2020) Rebecca A. Sager et al.   CELL STRESS & CHAPERONES

Bifunctional Molecules beyond PROTACs

(2020) Stuart J. Conway   JOURNAL OF MEDICINAL CHEMISTRY

Multispecific drugs herald a new era of biopharmaceutical innovation

(2020) Raymond J. Deshaies   NATURE

Phosphorylation-Inducing Chimeric Small Molecules

(2020) Sachini U. Siriwardena et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry

(2020) Wen-Hao Guo et al.   Nature Communications

PROTACs to address the challenges facing small molecule inhibitors

(2020) Pedro Martín-Acosta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

(2019) Michael J. Roy et al.   ACS Chemical Biology

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

(2019) William Farnaby et al.   Nature Chemical Biology

Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study

(2019) Sayumi Yamazoe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Delineating the role of cooperativity in the design of potent PROTACs for BTK

(2018) Adelajda Zorba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of PROTAC cooperative recognition for selective protein degradation

(2017) Morgan S Gadd et al.   Nature Chemical Biology

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Purification, auto-activation and kinetic characterization of apoptosis signal-regulating kinase I

(2017) John M. Pleinis et al.   PROTEIN EXPRESSION AND PURIFICATION

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Apoptosis signal-regulating kinase 1 exhibits oncogenic activity in pancreatic cancer

(2016) Youguang Luo et al.   Oncotarget

Selective activators of protein phosphatase 5 target the autoinhibitory mechanism

(2015) Veronika Haslbeck et al.   BIOSCIENCE REPORTS

Apoptosis signal-regulating kinase 1 as a therapeutic target

(2014) Yosuke Kawarazaki et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Comprehensive Mathematical Model for Three-Body Binding Equilibria

(2013) Eugene F. Douglass et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

(2012) Yoshito Terao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer

(2012) Yoku Hayakawa et al.   CANCER SCIENCE

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

(2010) Y. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperativity and biological complexity

(2008) Adrian Whitty   Nature Chemical Biology