Review
Chemistry, Physical
Gerasimos Odysseas Georgiou, Francesco Tarallo, Enrico Marchetti, Sergio Bizzarro
Summary: This review provides an overview of the outcomes of using various regenerative materials for the treatment of molars with class II furcation defects in patients with periodontitis. The use of regenerative materials shows potential benefits compared to open flap debridement, although the heterogeneity in study protocols and low levels of evidence limit definitive conclusions.
Review
Dentistry, Oral Surgery & Medicine
Joni Augusto Cirelli, Tiago Fiorini, Carlos Heitor Cunha Moreira, Rafael Scaf de Molon, Tamires Pereira Dutra, Enilson Antonio Sallum
Summary: Periodontal Regeneration has been a highly discussed topic in Periodontics, with significant progress observed in the field. Despite challenges, a critical reassessment of clinical and preclinical literature can help understand the factors influencing the success or failure of regenerative approaches and guide the selection of appropriate treatment plans.
BRAZILIAN ORAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Poranee Banyatworakul, Thanaphum Osathanon, Sujin Chumprasert, Prasit Pavasant, Nopadon Pirarat
Summary: The study showed that PRF derived from Thai buffaloes was more beneficial for the proliferation of canine periodontal ligament cells (cPDLs) compared to PRF derived from Murrah buffaloes, and also promoted cell migration and spreading. Additionally, PRF from Thai buffaloes enhanced mineral deposition in an osteogenic induction medium.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Enrico Limiroli, Andrea Calo, Pierpaolo Cortellini, Peter Eickholz, Akihiko Katayama, Jad Majzoub, Jennifer Wong, Pamela McClain, Ivan Cortinovis, Giulio Rasperini
Summary: This study discusses the relationship between the anatomy of the interradicular space and success in regenerative therapy of furcation defects. The results show that the success of regenerative therapy is not influenced by the conformation of the interradicular space, but is associated with treatment methods and clinical parameters.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Yao, J. E. Raymond, F. Kauffmann, S. Maekawa, J. Sugai, J. Lahann, W. Giannobile
Summary: This study designed and fabricated highly ordered multicompartmental scaffolds using melt electrowriting, aiming to mimic the hierarchical structure of native periodontal tissues. The multicompartmental constructs successfully achieved coordinated proliferation and differentiation of multiple cell types in vitro, and effectively recapitulated the key features of interfacial tissues in periodontium. This tissue-engineered approach offers a fundament for engineering periodontal tissue constructs with characteristic 3D microenvironments similar to native tissues.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
P. Mark Bartold, Saso Ivanovski
Summary: P4 Periodontics is a comprehensive, integrative, and proactive approach to periodontal treatment that emphasizes the four pillars of prediction, prevention, personalization, and participation. It is highly aligned with the 2018 Classification of Periodontal Diseases and introduces the concept of a treat-to-target focus for personalized treatment outcomes, as well as the application of personalized regenerative and rejuvenative periodontal therapies.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Simone Gallo, Maurizio Pascadopoli, Matteo Pellegrini, Federica Pulicari, Mattia Manfredini, Paolo Zampetti, Francesco Spadari, Carlo Maiorana, Andrea Scribante
Summary: Regenerative dentistry utilizes biomaterials and biologics to treat periodontal and peri-implant diseases, showing excellent results in clinical trials. Optimal outcomes require factors such as occlusal load control and prevention of microbial contamination.
BIOENGINEERING-BASEL
(2022)
Review
Chemistry, Physical
Eudoxie Pepelassi, Maria Deligianni
Summary: This systematic review and meta-analysis found that the adjunctive use of leucocyte- and platelet-rich fibrin (L-PRF) in periodontal endosseous defects and furcation defects significantly improved probing pocket depth, clinical attachment level, and radiographic defect depth in systemically healthy non-smokers.
Review
Medicine, General & Internal
Shahida Mohd-Said, Tuti Ningseh Mohd-Dom, Nawal Suhaimi, Haslina Rani, Colman McGrath
Summary: This systematic review found that pre-procedural mouth rinsing is effective in reducing aerosol contamination in the dental setting during periodontal prophylaxis, with chlorhexidine showing the most significant effects.
FRONTIERS IN MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Lingxi Meng, Yige Wei, Yaxian Liang, Qin Hu, Huixu Xie
Summary: The regeneration of periodontal tissue is a challenging issue in oral diseases, and tissue engineering has shown promise in addressing this problem. However, the source of exogenous seed cells remains a major obstacle. In recent years, the application of endogenous cell homing has gained attention and shown potential in clinical tissue repair, periodontal regeneration, and cell therapy prospects. Further research is needed to improve the efficiency of endogenous cell homing and expand its clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Health Care Sciences & Services
Takeshi Kikuchi, Jun-ichiro Hayashi, Akio Mitani
Summary: Periodontal disease is an infectious disease with a close relationship to lifestyle, and its treatment varies depending on individual patients. Precision medicine and personalized medicine offer more predictive treatment approaches, requiring a new diagnostic system and ongoing research on biomarkers, genetics, and oral bacteria complexity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yue Wang, Qingyue Xiao, Wenjie Zhong, Chuangwei Zhang, Yuanyuan Yin, Xiang Gao, Jinlin Song
Summary: This study evaluated the regeneration potential of periodontitis tissue treated with low-intensity pulsed ultrasound (LIPUS) combined with guided tissue regeneration (GTR) technique in a beagle model of furcation involvement. The results showed that LIPUS could enhance periodontal bone formation and bone matrix maturity in furcation involvement after GTR treatment, and also had anti-inflammatory and pro-angiogenic effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Veterinary Sciences
Bonnie L. Lee, Jason Soukup, Aaron Rendahl, Stephanie Goldschmidt
Summary: This study evaluated the clinical success rate of guided tissue regeneration (GTR) for treating advanced periodontal disease in a large canine cohort. The results showed that GTR was clinically successful in 90.3% of vertical bone defects and 22.2% of furcation defects. The success of GTR was significantly associated with the magnitude of initial probing depth and the type of barrier membrane used.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Bianca Costa Goncalves, Andre Luiz Ferreira Costa, Raquel Correa, Naira Maria Rebelatto Bechara Andere, Celso Massahiro Ogawa, Mauro Pedrine Santamaria, Sergio Lucio Pereira de Castro Lopes
Summary: This study found that the presence and height of infra-osseous defects significantly impact the success of the treatment, while the maximum area of lesion opening showed a negative correlation with treatment success in the surgery thorn EMD group.
Review
Dentistry, Oral Surgery & Medicine
Renuka K. Swami, Abhay P. Kolte, Girish H. Bodhare, Rajashri A. Kolte
Summary: The combination therapy of BRG+GTR showed additional benefits compared to monotherapy in resolving grade II furcation defects, especially in increasing vertical defect fill and horizontal defect fill.
CLINICAL ORAL INVESTIGATIONS
(2021)
Letter
Dentistry, Oral Surgery & Medicine
Lorenzo Lo Muzio, Francesca Spirito
Review
Biochemistry & Molecular Biology
Mattia Di Stefano, Simona Santonocito, Alessandro Polizzi, Rodolfo Mauceri, Giuseppe Troiano, Antonino Lo Giudice, Alessandra Romano, Marco Mascitti, Gaetano Isola
Summary: The human body is colonized by a diverse microbial community known as the microbiota, which plays a crucial role in influencing human health throughout life. The oral microbiota forms complex biofilms and interactions, contributing to the host's resistance to antimicrobial agents and maintaining a balanced symbiotic relationship. Understanding the functions and interactions of the microbiota is essential for developing diagnostic, therapeutic, and preventive strategies. This review focuses on the connection between the oral and gut microbiomes, and how alterations in these microbial communities can lead to oral and intestinal illnesses, as well as the potential role of probiotics in ameliorating inflammation and microbial dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roberto Campagna, Alessia Belloni, Valentina Pozzi, Alessia Salvucci, Valentina Notarstefano, Lucrezia Togni, Marco Mascitti, Davide Sartini, Elisabetta Giorgini, Eleonora Salvolini, Andrea Santarelli, Lorenzo Lo Muzio, Monica Emanuelli
Summary: Oral squamous cell carcinoma is the most aggressive and frequent form of head and neck cancer. Paraoxonase-2 enzyme has been identified as a potential molecular target for effective oral cancer treatment. Silencing paraoxonase-2 gene led to a reduction in cell proliferation and viability, enhanced sensitivity to cisplatin, and activation of the apoptosis pathway. These findings suggest that paraoxonase-2 could be a promising target for molecular treatment of oral cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Khrystyna Zhurakivska, Rossella Luciano, Vito Carlo Alberto Caponio, Lucio Lo Russo, Lorenzo Lo Muzio, Marco Mascitti, Giuseppe Troiano
Summary: This study conducted a cost-effectiveness analysis of different rehabilitative solutions for edentulous mandibles. The decision tree models showed that fixed dentures supported by 2 implants were the most cost-effective option, followed by overdentures retained by 2 implants. Probabilistic sensitivity analysis confirmed the dominance of these two strategies.
JOURNAL OF ORAL REHABILITATION
(2023)
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Cristian Quarta, Diego Sovereto, Elisabetta Basile, Andrea Ballini, Giorgia Apollonia Caloro, Giuseppe Troiano, Lorenzo Lo Muzio, Filiberto Mastrangelo
Summary: Prosthetic rehabilitation through dental implants can be improved using implant planning software and digitally designed surgical guides. This systematic review evaluates the success rates, bone remodeling, and possible complications related to guided implant surgery. The results show high implant survival rates, but early failures are common due to lack of osseointegration, and various factors influence implant survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Diego Lops, Eugenio Romeo, Magda Mensi, Giuseppe Troiano, Khrystyna Zhurakivska, Massimo Del Fabbro, Antonino Palazzolo
Summary: Computer-aided design and computer-aided manufacturing customized abutments are commonly used in clinical practice, but there is a lack of scientific evidence on their advantages in terms of soft tissue stability. This systematic review compared prefabricated and customized (CAD/CAM) abutments in terms of soft tissue outcomes. The analysis of six clinical trials showed no significant differences in midfacial mucosal recession, interproximal papillae, and pink aesthetic score after 12 months. The potential benefits of CAD/CAM abutments on soft tissues should be further investigated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Andrea Ballini, Giorgia Apollonia Caloro, Lorenzo Lo Muzio
Summary: Antiresorption drugs like bisphosphonates and monoclonal antibodies are used in the treatment of osteoporosis and other bone-related diseases. These drugs have been associated with cases of osteonecrosis of the jaws (MRONJ). Risk factors include extraction procedures in oral surgery, particularly in the mandible and maxilla. A systematic review and meta-analysis was conducted to determine if there is a greater risk of MRONJ in male or female subjects and to assess the involvement of osteonecrosis in different extraction sites. After analyzing 24 studies, the results showed a trend of higher risk in males and in the posterior mandibular sector, but further studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Antonio Cortese, Francesca Spirito, Pier Paolo Claudio, Lorenzo Lo Muzio, Alessandro Ruggiero, Maurizio Gargiulo
Summary: Virtual surgical planning for CAD/CAM mandibular reconstruction using titanium prosthesis has been recently reported. However, there may be difficulties in TMJ function due to prosthesis contamination from oral mucosa dehiscence. Two cases of mandibular reconstruction after ameloblastoma resection using custom-made CAD/CAM titanium prosthesis were presented, aiming to preserve TMJ function and avoid intraoral incisions. Finite elements analysis was performed to ensure the efficacy of the prosthetic device. Although successful, there are still drawbacks and risks, and limitations and side effects must be considered when using this technique.
Review
Biochemistry & Molecular Biology
Gaia Viglianisi, Simona Santonocito, Alessandro Polizzi, Giuseppe Troiano, Mariacristina Amato, Khrystyna Zhurakivska, Paolo Pesce, Gaetano Isola
Summary: Circulating cell-free DNA (cfDNA) plays an important role in cell apoptosis or necrosis, including in the development and evolution of tumors and inflammatory diseases. Periodontitis, a chronic inflammatory disease, may be linked to various systemic inflammatory diseases. A possible correlation between periodontal disease and cfDNA has been discovered, offering new perspectives for diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ilaria Cela, Vito Carlo Alberto Caponio, Emily Capone, Morena Pinti, Marco Mascitti, Lucrezia Togni, Lorenzo Lo Muzio, Corrado Rubini, Vincenzo De Laurenzi, Rossano Lattanzio, Vittoria Perrotti, Gianluca Sala
Summary: The present study suggests that LGALS3BP is highly expressed in oral squamous cell carcinoma (OSCC) and may serve as a potential diagnostic biomarker and therapeutic target for ADC-based therapy. The study also found a correlation between high LGALS3BP expression levels and aggressive histological features of OSCC. Additionally, OSCC cell lines with high LGALS3BP expression showed high sensitivity to the ADC-payload DM4.
Article
Dentistry, Oral Surgery & Medicine
Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Marco Mascitti, Lucrezia Togni, Francesca Spirito, Nicola Cirillo, Lorenzo Lo Muzio, Giuseppe Troiano
Summary: This study explores the predictive value of TP53 mutations in treatment outcomes for HNSCC patients. It demonstrates that high-risk-of-death mutations are associated with a higher risk of stable/progressive disease, particularly in older patients with a history of alcohol consumption. Additionally, it suggests the potential usefulness of two classification systems for TP53 mutational landscapes.
Article
Dentistry, Oral Surgery & Medicine
Andrew Bergmann, Changyong Feng, Konstantinos Chochlidakis, Lucio Lo Russo, Carlo Ercoli
Summary: The study aimed to measure and compare alveolar ridge mucosa thickness in completely edentulous patients using an ultrasonic gingival scanner. The results showed significant differences at certain sites and among different races, but the clinical significance of these differences remains uncertain.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2023)
Article
Chemistry, Multidisciplinary
Vincenzo Brescia, Angela Pia Cazzolla, Antonietta Fontana, Lucia Varraso, Carmela Capobianco, Roberto Lovero, Lorenzo Lo Muzio, Mario Dioguardi, Maria Felicia Faienza, Vito Crincoli, Francesca Di Serio, Domenico Ciavarella
Summary: This study investigated the biological variability of bone turnover markers (BTM) in saliva samples of young subjects. The results showed differences in the variability of BTM, including PTHrP, TRAcP-5b, and P1NP, in saliva. The detection of BTM changes in saliva is important for oral pathology and dental treatment, particularly in determining treatment timing and evaluating the effectiveness of orthodontic treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Lucio Lo Russo, Laura Guida, Pierluigi Mariani, Vincenzo Ronsivalle, Crescenzio Gallo, Marco Cicciu, Luigi Laino
Summary: The study investigated the impact of milling and 3D printing technologies on the accuracy of surgical guides. The results showed that the milled guides had smaller deviations in the contact surface with the mucosa compared to the 3D-printed guides. Additionally, the milling technology performed better in terms of axial and linear deviations of the sleeves' housings. Therefore, milling technology can provide more accurate surgical guides.
BIOENGINEERING-BASEL
(2023)