Regulation of PKD2 channel function by TACAN

Analysis of the mechanosensor channel functionality of TACAN

(2021) Yiming Niu et al.   eLife

TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

(2021) Jing Xue et al.   eLife

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

(2021) Yao Rong et al.   eLife

Cryo-EM structures of human TMEM120A and TMEM120B

(2021) Meng Ke et al.   Cell Discovery

Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions

(2021) Thibaud Parpaite et al.   Cell Reports

TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

(2020) Lou Beaulieu-Laroche et al.   CELL

Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid

(2020) Xixin Wang et al.   Toxins

Autoinhibition of TRPV6 channel and regulation by PIP2

(2020) Ruiqi Cai et al.   iScience

Structure and function of polycystins: insights into polycystic kidney disease

(2019) Dominique Douguet et al.   Nature Reviews Nephrology

TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

(2019) Malika Arhatte et al.   Nature Communications

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex

(2019) Zhifei Wang et al.   EMBO REPORTS

Mammalian TRP ion channels are insensitive to membrane stretch

(2019) Yury A. Nikolaev et al.   JOURNAL OF CELL SCIENCE

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

(2018) Wang Zheng et al.   Nature Communications

TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels

(2018) Evan O. Anderson et al.   Cell Reports

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

(2018) Wang Zheng et al.   Cell Reports

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

(2018) Xiaowen Liu et al.   eLife

Structure of the human PKD1-PKD2 complex

(2018) Qiang Su et al.   SCIENCE

Polycystic kidney disease

(2018) Carsten Bergmann et al.   Nature Reviews Disease Primers

The mechano-sensitivity of cardiac ATP-sensitive potassium channels is mediated by intrinsic MgATPase activity

(2017) Mohammad Fatehi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

Far Upstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 and Suppresses Its Translation

(2016) W. Zheng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

(2016) Mahmud Arif Pavel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation

(2015) Dzmitry G. Batrakou et al.   PLoS One

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management

(2013) R. L. Luciano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Structural Interaction and Functional Regulation of Polycystin-2 by Filamin

(2012) Qian Wang et al.   PLoS One

Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope

(2010) Poonam Malik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heteromerization of TRP channel subunits: extending functional diversity

(2010) Wei Cheng et al.   Protein & Cell

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

The Transient Receptor Potential Channels TRPP2 and TRPC1 Form a Heterotetramer with a 2:2 Stoichiometry and an Alternating Subunit Arrangement

(2009) Toshiro Kobori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

(2009) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

TRPP2 and TRPV4 form a polymodal sensory channel complex

(2008) Michael Köttgen et al.   JOURNAL OF CELL BIOLOGY