Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview

A tissue-specific role of membrane-initiated ERα signaling for the effects of SERMs

(2022) Karin L Gustafsson et al.   JOURNAL OF ENDOCRINOLOGY

2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism

(2022) Candice B. Herber et al.   MOLECULAR MEDICINE

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Aromatase Inhibitors for the Treatment of Breast Cancer: A Journey from the Scratch

(2020) Pooja Ratre et al.   Anti-Cancer Agents in Medicinal Chemistry

Most recent strategies targeting estrogen receptor alpha for the treatment of breast cancer

(2020) Nitish Kumar et al.   MOLECULAR DIVERSITY

Estrogen signaling: An emanating therapeutic target for breast cancer treatment

(2019) Tanmay Saha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational approaches of drug design for the development of selective estrogen receptor modulators (SERMs), implicated in breast cancer

(2019) Subhajit Makar et al.   BIOORGANIC CHEMISTRY

Species differences in ligand interaction and activation of estrogen receptors in fish and human

(2019) Solomon Asnake et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators

(2018) Ramit Singla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Screening of over 1000 Indian patients with breast and/or ovarian cancer with a multi-gene panel: prevalence of BRCA1/2 and non-BRCA mutations

(2018) Jaya Singh et al.   BREAST CANCER RESEARCH AND TREATMENT

Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-α)

(2018) Ramit Singla et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel cyclopropyl derivatives as subtype-selective ligands for estrogen receptor

(2018) Zunyuan Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Design, synthesis, anti-proliferative evaluation and docking studies of 1H-1,2,3-triazole tethered ospemifene–isatin conjugates as selective estrogen receptor modulators

(2018) Sumit Kumar et al.   NEW JOURNAL OF CHEMISTRY

Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment

(2018) Hitisha K. Patel et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis, computational studies and antiproliferative activities of coumarin-tagged 1,3,4-oxadiazole conjugates against MDA-MB-231 and MCF-7 human breast cancer cells

(2018) Sanjeev Dhawan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Estrogen alpha receptor antagonists for the treatment of breast cancer: a review

(2018) Deepika Sharma et al.   Chemistry Central Journal

Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

(2018) Xinyu Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Germline BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India

(2018) Anurag Mehta et al.   Cancer Management and Research

Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ERα/VEGFR-2 ligands for treatment of breast cancer

(2017) Guoshun Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Selective Estrogen Receptor Modulator (SERM)-like Activities of Diarylheptanoid, a Phytoestrogen from Curcuma comosa, in Breast Cancer Cells, Pre-osteoblast Cells, and Rat Uterine Tissues

(2017) Natthakan Thongon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy

(2017) Junjie Luo et al.   MedChemComm

Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists

(2017) Sehan Lee et al.   PLoS One

Design, synthesis, and anti-breast cancer evaluation of new triarylethylene analogs bearing short alkyl- and polar amino-/amido-ethyl chains

(2016) Gurleen Kaur et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The selective estrogen receptor modulators in breast cancer prevention

(2016) Fangxuan Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Glyceollins and dehydroglyceollins isolated from soybean act as SERMs and ER subtype-selective phytoestrogens

(2016) Milou G.M. van de Schans et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Estrogen receptor signaling during vertebrate development

(2015) Maria Bondesson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Synthesis and biological evaluation of novel m-carborane-containing estrogen receptor partial agonists as SERM candidates

(2015) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis,in Vitro, and in VivoBiological Evaluation and Molecular Docking Analysis of Novel 3-(3-oxo-substitutedphenyl-3-)4-(2-(piperidinyl)ethoxy)phenyl)propyl)-2H-chromen-2-one Derivatives as Anti-breast Cancer Agents

(2015) Pritam N. Dube et al.   Chemical Biology & Drug Design

Synthesis of 4,4′-Diaminotriphenylmethanes with Potential Selective Estrogen Receptor Modulator (SERM)-like Activity

(2015) Gema Guedes et al.   ChemMedChem

Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors

(2015) Wei Lv et al.   JOURNAL OF MEDICINAL CHEMISTRY

From bench to bedside: What do we know about hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer?

(2015) Victoria Shang Wu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer

(2014) V Craig Jordan   ENDOCRINE-RELATED CANCER

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

(2014) Ilaria Paterni et al.   STEROIDS

Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents

(2014) M. Kamil Hussain et al.   RSC Advances

Aerobic Iron-Based Cross-Dehydrogenative Coupling Enables Efficient Diversity-Oriented Synthesis of Coumestrol-Based Selective Estrogen Receptor Modulators

(2013) Umesh A. Kshirsagar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Potential of Selective Estrogen Receptor Modulators as Treatments and Preventives of Breast Cancer

(2012) Jing Peng et al.   Anti-Cancer Agents in Medicinal Chemistry

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells

(2012) Yong Leng Kelvin Tan et al.   DALTON TRANSACTIONS

Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells

(2012) Yangfan Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus

(2012) Wai Ho Tang et al.   Frontiers in Pharmacology

Structure-Based Approach for the Discovery of Novel Selective Estrogen Receptor Modulators

(2011) C. Rosano et al.   CURRENT MEDICINAL CHEMISTRY

Aromatase, aromatase inhibitors, and breast cancer

(2011) Saranya Chumsri et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

An “Omics” Approach to Determine the Mechanisms of Acquired Aromatase Inhibitor Resistance

(2011) Shiuan Chen   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

High-dose toremifene as first-line treatment of metastatic breast cancer resistant to adjuvant aromatase inhibitor: A multicenter phase II study

(2011) MASATAKA SAWAKI et al.   Oncology Letters

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer

(2009) Shailesh Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular mechanisms of endocrine resistance and their implication in the therapy of breast cancer

(2008) Marinella Zilli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators

(2008) Irene Barrett et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer

(2008) Mingzhang Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tamoxifen: Catalyst for the change to targeted therapy

(2007) V. Craig Jordan   EUROPEAN JOURNAL OF CANCER