Article
Gastroenterology & Hepatology
Brigida Barberio, Lesley A. Houghton, Yan Yiannakou, Edoardo Savarino, Christopher J. Black, Alexander C. Ford
Summary: The study found that among individuals self-identifying as having IBS, the diagnosis and subtype of IBS were less stable, and starting new treatments did not affect symptom stability.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pediatrics
Omer Faruk Beser, Fugen Cullu Cokugras, Guzide Dogan, Ozlem Akgun, Murat Elevli, Pinar Yilmazbas, Meric Ocal, Nevzat Aykut Bayrak, Rabia Gonul Sezer Yamanel, Abdulkadir Bozaykut, Coskun Celtik, Esra Polat, Nelgin Gerenli, Serdar Bozlak, Hasret Ayyildiz Civan, Neslihan Ozkul Saglam, Sadik Sami Hatipoglu, Gamze Ozgurhan, Eda Sunnetci Silistre, Burcu Solmaz, Gunsel Kutluk, Hamide Sevinc Genc, Hasan Onal, Ayse Merve Usta, Nafiye Urganci, Ayse Sahin, Sebahat Cam, Sema Yildirim, Asilay Yildirim, Yvan Vandenplas
Summary: This study aimed to determine the prevalence of infantile functional gastrointestinal disorders (FGIDs) based on Rome IV diagnostic criteria, and found that early diversification was associated with the presence of FGIDs. The study included 2383 infants, among which 35.1% had at least one FGID, with infant colic, infant regurgitation, and infant dyschezia being the most common.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Huanhuan Huang, Caiyun Wang, Wei Lin, Yongbin Zeng, Bin Wu
Summary: This study aimed to evaluate the prevalence of infant FGIDs in southern Fujian according to the Rome IV diagnostic criteria. The study found a high prevalence of FGIDs in infants living in southern Fujian, with the most common FGIDs being regurgitation, difficult defecation, and functional constipation. Younger paternal age, parental history of FGIDs, and probiotic supplementation in infants were significantly associated with infant FGIDs, while vitamin D supplementation in infants was found to be a protective factor against FGIDs.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Desiree F. Baaleman, Carlos A. Velasco-Benitez, Laura M. Mendez-Guzman, Marc A. Benninga, Miguel Saps
Summary: There was minimal agreement in diagnosing FGIDs between the Rome III and Rome IV criteria in pediatric population. Differences were observed in specific disorders such as functional constipation and functional dyspepsia. Limitations with questionnaire-based prevalence measurement need to be considered.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
Summary: This study provides contemporary estimates of direct healthcare costs of IBS in the UK, finding that individuals with opiate use, more severe symptoms, shorter duration of IBS, lower quality of life, and higher levels of depression require higher healthcare costs.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pediatrics
Cathrine Gatzinsky, Ulla Sillen, Sarah Thornberg, Sofia Sjostrom
Summary: This study aims to provide data on stool frequency and consistency during the first year, prevalence rates for functional constipation (FC) and to establish associations with relevant demographic data. The occurrence of infant colic (IC) and infant dyschezia (ID) was also reported. The study found that FGID during infancy is common and affects children's well-being, while their families need support and advice.
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Lesley A. Houghton, Yan Yiannakou, Christopher J. Black, Alexander C. Ford
Summary: This study found that the natural history of irritable bowel syndrome (IBS) defined according to the Rome IV criteria is more severe compared to IBS defined by the Rome III criteria. Approximately 60% of the participants met the Rome IV criteria, while approximately 40% met the Rome III criteria. Individuals with Rome IV IBS were more likely to seek medical care, start new treatments, and have more treatment cycles compared to those with Rome III IBS. Additionally, Rome IV IBS patients had more severe symptoms, greater impact on daily activities, and poorer psychological health.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Brigida Barberio, Yan Yiannakou, Lesley A. Houghton, Christopher J. Black, Edoardo Savarino, Alexander C. Ford
Summary: In a longitudinal study, individuals with overlapping symptoms of IBS and FD were found to have more severe conditions, higher rates of seeking medical help, and greater psychological health issues compared to those with IBS alone.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pediatrics
Ying Huang, Serene Yaling Tan, Panam Parikh, Vanitha Buthmanaban, Shaman Rajindrajith, Marc Alexander Benninga
Summary: The study aimed to assess the prevalence of functional gastrointestinal disorders (FGIDs) in infants and young children in China. According to the Rome IV criteria, the prevalence of having a FGID in Chinese infants and young children is 27.3%. Infantile regurgitation was the most common FGID in Chinese infants, while functional constipation was most prevalent among young Chinese children.
Article
Gastroenterology & Hepatology
James K. Ruffle, Linda Tinkler, Christopher Emmett, Alexander C. Ford, Parashkev Nachev, Qasim Aziz, Adam D. Farmer, Yan Yiannakou
Summary: Machine learning analysis of a large prospective cohort of patients with chronic constipation revealed that irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC) only differ significantly in the presence of abdominal pain, suggesting that they may not be distinct syndromes but rather a single syndrome varying along a single clinical dimension. This has implications for patient recruitment into clinical trials, future disease classifications, and management guidelines.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Clinical Neurology
Yi-Cheng Tai, Peng-Hsiang Liao, Valentina Leta, Chin-Hsien Lin, K. Ray Chaudhuri
Summary: This study investigated the prevalence of functional gastrointestinal disorders in Parkinson's disease (PD) patients and its correlation with the clinical severity of PD. The results showed that constipation and irritable bowel syndrome (IBS) were more common in PD patients than controls. The severity of IBS was associated with non-motor symptom burden, especially mood symptoms, while the severity of constipation was correlated with motor symptom severity.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Gastroenterology & Hepatology
Irina Midenfjord, Adam Borg, Hans Tornblom, Magnus Simren
Summary: This study found that psychological alterations are common in patients with irritable bowel syndrome (IBS) and there is often overlap among various psychological factors. Five psychological factors (physical fatigue, GI-specific anxiety, perceived stress, pain catastrophizing, and trait anxiety) were significantly associated with the severity of GI symptoms. An increasing number of these psychological alterations also led to a gradual increase in the overall severity of GI symptoms.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Maria Elisabetta Baldassarre, Linda A. Antonucci, Germana Castoro, Antonio Di Mauro, Margherita Fanelli, Francesca Maria Grosso, Rosalinda Cassibba, Nicola Laforgia
Summary: The study suggests that maternal psychological factors may play a role in the development of infant FGIDs. Early screening for postpartum depression symptoms and psychological interventions in the postpartum period could help improve the health of the mother-infant dyad.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Mais Khasawneh, Orla F. Craig, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: The study suggests that diagnosing IBS according to the Rome IV criteria and conducting limited investigation is safe and durable. Among IBS patients, although 1 in 6 were referred again due to gastrointestinal symptoms, missed organic gastrointestinal disease occurred in only 1% of patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mohamed G. Shiha, Zohaib Asghar, Mo Thoufeeq, Matthew Kurien, Alex J. Ball, Anupam Rej, Foong Way David Tai, Shima Afify, Imran Aziz
Summary: IBS patients, according to Rome IV criteria, show higher levels of psychological distress and somatization compared to FD or FC patients. Abdominal pain frequency is positively correlated with extra-intestinal symptoms. No significant differences were found in mood and somatization scores between individual IBS subtypes or between FC and FD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)