Review
Obstetrics & Gynecology
Marie-Madeleine Dolmans, Michael von Wolff, Catherine Poirot, Cesar Diaz-Garcia, Luciana Cacciottola, Nicolas Boissel, Jana Liebenthron, Antonio Pellicer, Jacques Donnez, Claus Yding Andersen
Summary: The feasibility of freezing and thawing ovarian tissue is well-documented, but ovarian tissue transplantation is progressing at a slower pace with limited clinical experience. Results from five European centers show a low risk of relapse with ovarian tissue reimplantation and successful recovery of endocrine function in most patients, although in vitro fertilization efficacy needs improvement. Chemotherapy before ovarian tissue cryopreservation does not significantly affect success rates. Further research is needed to optimize the approach for ovarian tissue transplantation.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Kutluk Oktay, Loris Marin, Giuliano Bedoschi, Fernanda Pacheco, Yodo Sugishita, Tai Kawahara, Enes Taylan, Carlo Acosta, Heejung Bang
Summary: Robot-assisted autologous cryopreserved ovarian tissue transplantation (RA-ACOTT) resulted in extended graft longevity, with ovarian functions restored in all cases.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Xiangyan Ruan, Jiaojiao Cheng, Juan Du, Fengyu Jin, Muqing Gu, Yanglu Li, Rui Ju, Yurui Wu, Huanmin Wang, Wei Yang, Haiyan Cheng, Long Li, Wenpei Bai, Weimin Kong, Xin Yang, Shulan Lv, Yuejiao Wang, Yu Yang, Xin Xu, Lingling Jiang, Yanqiu Li, Alfred O. Mueck
Summary: This study investigates the effectiveness and feasibility of ovarian tissue cryopreservation (OTC) in children facing gonadotoxicity treatment. The results suggest that OTC is a safe and effective method for preserving the fertility of prepubertal girls, and chemotherapy does not affect the effectiveness of OTC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Marine Grellet-Grun, Beatrice Delepine, Pauline Le Van Quyen, Gerlinde Averous, Anne Durlach, Cecile Greze, Laetitia Ladureau-Fritsch, Isabelle Lichtblau, Anne-Sophie Canepa, Antoine Line, Catherine Paillard, Claire Pluchart, Olivier Pirrello, Catherine Rongieres, Ghassan Harika, Francois Becmeur, Marius Teletin
Summary: Ovarian tissue cryopreservation (OTC) is an effective fertility preservation option for pediatric patients undergoing gonadotoxic therapies. A retrospective study in France showed that the most common indication for OTC in children was stem cell transplantation. The number of ovarian tissue fragments collected during surgery was correlated with patient age, and the long-term follow-up revealed a high survival rate but a significant proportion of patients with premature ovarian insufficiency (POI).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiangyan Ruan, Jiaojiao Cheng, Juan Du, Fengyu Jin, Muqing Gu, Rui Ju, Yurui Wu, Long Li, Yuejiao Wang, Lingling Jiang, Yu Yang, Yanqiu Li, Zecheng Wang, Jun Ma, Mingzhen Zhang, Alfred O. Mueck
Summary: This study retrospectively analyzed children with rare diseases who underwent ovarian tissue cryopreservation (OTC) in China's first and largest ovarian tissue cryobank. The results showed no significant difference in OTC outcomes between rare disease patients and age-matched children with non-rare diseases. The findings provide valuable information for counseling girls with rare diseases about fertility preservation and indicate the increasing demand for OTC in pediatrics.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ashley A. Diaz, Hana Kubo, Nicole Handa, Maria Hanna, Monica M. Laronda
Summary: Ovarian tissue cryopreservation is the only option for preserving fertility in prepubescent girls and patients who cannot undergo ovarian stimulation. Despite the lack of standardized processing methods, ovarian tissue transplantation can restore ovarian hormone activity regardless of processing size.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Lin Chen, Zirui Dong, Xiaoyan Chen
Summary: Survival rates for children and adolescents with malignancy have increased due to advances in oncology treatments, but these treatments can have toxic effects on the reproductive organs. Cryopreservation of oocytes and sperm is recognized as an effective strategy for preserving fertility in pubertal patients, while the use of hormonal agonists for ovarian protection is controversial. Ovarian tissue cryopreservation is the only option for prepubertal girls, but the outcomes after transplantation are varied. Immature testicular tissue cryopreservation is experimental for prepubertal boys. Guidelines for fertility preservation exist, but implementation in clinical practice is limited. This review aims to discuss indications, outcomes, and workflow for fertility preservation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Fengyu Jin, Yanglu Li, Xiaowei Liu, Husheng Wang, Muqing Gu, Alfred O. Mueck
Summary: This study is the first worldwide report on using ovarian tissue cryopreservation (OTC) for fertility preservation in a patient with pregnancy-related breast cancer. The results show that OTC does not delay breast cancer treatment and does not have negative impacts even after more than 2 years of follow-up.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Marcos Eiji Shiroma, Luciana Lamarao Damous, Fernanda Pereira Cotrim, Cristiane Lima Roa, Jose Cipolla-Neto, Russel Joseph Reiter, Edmund Chada Baracat, Jose Maria Soares Jr
Summary: Melatonin pretreatment improves the quality of rat ovarian grafts by promoting the restart of the estrous cycle, increasing the expression of various key proteins in the ovaries, and reducing apoptosis levels. Further studies on reproductive function enhancement are warranted based on these findings.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Raffaella Fabbri, Rossella Vicenti, Valentina Magnani, Roberto Paradisi, Mario Lima, Lucia De Meis, Stefania Rossi, Diego Raimondo, Paolo Casadio, Stefano Venturoli, Michela Maffi, Renato Seracchioli
Summary: This study reports the 20-year experience of the Bologna clinical center in ovarian tissue cryopreservation and transplantation. The results show that ovarian tissue cryopreservation is an effective technique for preserving ovarian function in pediatric and adult patients, and it can help restore menstruation and achieve pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Janice de Miranda Vasconcellos Vilela, Marie-Madeleine Dolmans, Christiani Andrade Amorim
Summary: The practice of transporting ovarian tissue over long periods has been growing rapidly, but more clinical validation is needed despite reported successes. Current research is mainly focused on animal models, providing valuable insights for future studies involving humans.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Editorial Material
Obstetrics & Gynecology
Alla Vash-Margita, Katarzyna Szymanska-Vandendriessche, Kathryn Gunther, David F. Rodriguez-Buritica, Emily Christison-Lagay, Saurabh Saluja, Kutluk H. Oktay
Summary: This article describes an approach to fertility preservation through ovarian tissue harvesting and cryopreservation for a toddler with galactosemia. The authors highlight the importance of intervention for early preservation of fertility in patients with progressive primary ovarian insufficiency associated with galactosemia. A multidisciplinary team is involved in the procedure, including reproductive endocrinology and infertility specialists, pediatric gynecologists and surgeons, and genetics experts.
FERTILITY AND STERILITY
(2022)
Article
Rheumatology
Aurore Moussiegt, Claire Francois, Olivier Belmonte, Julien Jaubert, Nicolas Traversier, Sandrine Picot, Francoise Josse, Xavier Guillot, Patrice Poubeau, Marie-Pierre Moiton, Antoine Bertolotti, Loic Raffray
Summary: Gonococcal arthritis (GA) is rare but important to diagnose early and treat promptly to prevent joint destruction. Use of PCR in joint puncture is useful in cases with negative culture.
CLINICAL RHEUMATOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Fengyu Jin, Muqing Gu, Alfred Mueck, Yurui O. Wu
Summary: The case report highlighted the importance of early evaluation for fertility preservation in TS patients and suggested OTC as a reasonable option for highly selected young females with mosaic TS, as long as endocrine evaluation does not indicate POI and other health problems do not rule out future pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Stine Gry Kristensen, Yu Wakimoto, Lotte Berdiin Colmorn, Margit Dueholm, Susanne Elisabeth Pors, Kirsten Tryde Macklon, Linn Salto Mamsen, Dmitry Nikiforov, Jesus Cadenas, Vinnie Hornshoj Greve, Anne-Mette Bay Bjorn, Mikkel Rosendahl, Anette Tonnes Pedersen, Anders Nyboe Andersen, Jens Fedder, Erik Ernst, Claus Yding Andersen
Summary: This study evaluated the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort, revealing that OTT rates depended on diagnosis, age at OTC, and follow-up time. Longer follow-up is needed, especially for younger girls.
FERTILITY AND STERILITY
(2021)
