Kidney-specific knockout ofSav1in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

(2015) Yonggang Zheng et al.   DEVELOPMENTAL CELL

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

Conditional inactivation of the mouse von Hippel–Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney

(2014) T L Pritchett et al.   ONCOGENE

In vivo quantitative phosphoproteomic profiling identifies novel regulators of castration-resistant prostate cancer growth

(2014) N Jiang et al.   ONCOGENE

Bap1is essential for kidney function and cooperates withVhlin renal tumorigenesis

(2014) Shan-Shan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Signaling Mediates Proliferation, Invasiveness, and Metastatic Potential of Clear Cell Renal Cell Carcinoma

(2014) Ute Schütte et al.   Translational Oncology

Combined mutation ofVhlandTrp53causes renal cysts and tumours in mice

(2013) Joachim Albers et al.   EMBO Molecular Medicine

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Regulation of the Hippo pathway and implications for anticancer drug development

(2013) Hyun Woo Park et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Organ Size Control by Hippo and TOR Pathways

(2012) Karen Tumaneng et al.   CURRENT BIOLOGY

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

(2012) Kendall S. Frazier et al.   TOXICOLOGIC PATHOLOGY

Association of Advanced Chronic Progressive Nephropathy (CPN) with Renal Tubule Tumors and Precursor Hyperplasia in Control F344 Rats from Two-Year Carcinogenicity Studies

(2012) Gordon C. Hard et al.   TOXICOLOGIC PATHOLOGY

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

(2011) Keiko Matsuura et al.   BMC CANCER

Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1 

(2011) L. Fu et al.   CANCER RESEARCH

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL