Article
Health Care Sciences & Services
Meera R. Agar, Sungwon Chang, Ingrid Amgarth-Duff, Maja Garcia, Jane Hunt, Jane L. Phillips, Aynharan Sinnarajah, Robin Fainsinger
Summary: This study aimed to assess the net clinical effects of hypodermoclysis in palliative patients who required supplementary fluids. The results showed that hypodermoclysis may improve certain symptoms but the frequency of harms and benefits may vary at different stages of the illness trajectory.
PALLIATIVE MEDICINE
(2022)
Article
Oncology
Cheng-Jen Ma, Ching-Wen Huang, Yung-Sung Yeh, Hsiang-Lin Tsai, Wei-Chih Su, Tsung-Kun Chang, Li-Chu Sun, Ying-Ling Shih, Fang-Jung Yu, Deng-Chyang Wu, Jaw-Yuan Wang
Summary: This study aimed to clarify the role of supplemental home parenteral nutrition (HPN) in patients with incurable gastric cancer (GC) undergoing salvage chemotherapy. Results showed that HPN therapy improved nutritional status, body weight, and quality of life in malnourished patients with unresectable or metastatic GC. Early HPN intervention should be considered an important part of palliative treatment for advanced GC.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Geriatrics & Gerontology
Mathias Brix Danielsen, Elisa Worthington, Jesper Scott Karmisholt, Jorn Munkhof Moller, Martin Gronbech Jorgensen, Stig Andersen
Summary: This study aimed to explore whether subcutaneous hydration is a safe alternative to intravenous hydration. The results showed that subcutaneous hydration was non-inferior to intravenous hydration in terms of adverse effects and had a shorter insertion time. Therefore, subcutaneous hydration should be available as a method of hydration in the care of older adults.
Article
Critical Care Medicine
Mette M. Berger, Rosa Burgos, Michael P. Casaer, Edoardo De Robertis, Juan Carlos Lopez Delgado, Vincent Fraipont, Joao Goncalves-Pereira, Claude Pichard, Christian Stoppe
Summary: The manuscript summarizes the discussions of an international group of physicians on the value and role of supplemental parenteral nutrition in critically ill patients. Experts agreed on the clinical benefits of SPN but noted heterogeneity in its use across European countries and insufficient education. They called for actions to improve the evidence quality on specific patient use of SPN during acute critical illness or recovery.
Review
Oncology
Paolo Cotogni, Federico Bozzetti, Francois Goldwasser, Paula Jimenez-Fonseca, Sine Roelsgaard Obling, Juan W. Valle
Summary: Malnutrition is often overlooked in cancer patients and is associated with various negative effects. Nutritional assessment and intervention should be an integral part of cancer treatment plans. However, there is a lack of data on artificial nutrition based on caloric needs during cancer care.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Peng Li, ChunYan Zhong, ShiBin Qiao, JunJun Liu
Summary: Supplemental parenteral nutrition (SPN) plus enteral nutrition (EN) can reduce the risk of infection in critically ill patients, but it has no significant effect on all-cause mortality.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Analytical
Carlotta Malvuccio, Ernest N. Kamavuako
Summary: As the elderly population increases, there is a need for healthcare technologies to monitor fluid intake. This study investigated the potential of combining optimal features from sEMG sensors to improve classification and estimation accuracy. Results showed promising accuracy in differentiating between liquid swallows and non-liquid swallowing events, as well as estimating the volume of fluid intake.
Article
Nutrition & Dietetics
Joohyun Sim, Jeong Hong, Eun Mi Na, Seorin Doo, Yun Tae Jung
Summary: The study aimed to evaluate the benefit of early supplemental parenteral nutrition in critically ill patients undergoing surgery who are not eligible for early enteral nutrition. Patients with high malnutrition risk who received early PN supplementation had lower 30-day and in-hospital mortality rates compared to those who did not receive PN earlier.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Koji Amano, Isseki Maeda, Hiroto Ishiki, Tomofumi Miura, Yutaka Hatano, Hiroaki Tsukuura, Tomohiko Taniyama, Yoshihisa Matsumoto, Yosuke Matsuda, Hiroyuki Kohara, Tatsuya Morita, Masanori Mori
Summary: This study demonstrated the clinical benefits of enteral nutrition (EN) and parenteral nutrition and hydration (PNH) for patients with advanced cancer, showing significantly lower risk of mortality in both EN and PNH groups compared to the control group. Moreover, it was found that managing symptoms to improve oral intake is essential before initiating PNH, as EN was superior to PNH in terms of survival outcomes.
CLINICAL NUTRITION
(2021)
Review
Endocrinology & Metabolism
Emma J. Ridley
Summary: Recent developments in understanding the application of parenteral nutrition in critically ill patients include consideration of phases of illness, avoidance of overfeeding, appropriate patient populations, and the setting in which parenteral nutrition is provided. The decision to provide parenteral nutrition should be carefully considered based on factors such as illness stage, nutrition status, treatment goals, and setting.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2021)
Article
Nutrition & Dietetics
Lea Kum, Alexander Friedrich, Markus Kieler, Elias Meyer, Petar Popov, Paul Koessler, Anna Kitta, Feroniki Adamidis, Raimund Oberle, Eva Katharina Masel, Matthias Unseld
Summary: This study found that increased kidney function parameters, such as creatinine, urea, and uric acid, may serve as negative prognostic markers in palliative care patients receiving parenteral nutrition (PN). Additionally, an increase in creatinine within the first 2 weeks of PN administration is associated with worse outcomes.
Article
Medicine, General & Internal
Sittelbenat Adem, Nabil ALMouaalamy
Summary: This pilot study aimed to assess the effectiveness and safety of hypodermoclysis (HDC) for home-based palliative cancer patients, concluding that HDC is an effective and safe option that can enhance patient comfort and avoid hospitalization. The study successfully completed 25 (92.6%) HDC treatments for palliative patients, with no serious side effects observed and a mean infusion duration of 8.44 hours.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Bindong Xu, Hao Chen, Qiang Zhang, Pengfei Chen
Summary: Supplemental parenteral nutrition can improve postoperative nutritional status, immune function, and inflammatory response in patients with esophageal cancer.
Article
Multidisciplinary Sciences
Mario Kofler, Ronny Beer, Stephanie Marinoni, Alois J. Schiefecker, Maxime Gaasch, Verena Rass, Anna Lindner, Bogdan A. Lanosi, Paul Rhomberg, Bettina Pfausler, Claudius Thome, John F. Stover, Erich Schmutzhard, Raimund Helbok
Summary: Enteral nutrition is often insufficient for subarachnoid hemorrhage patients to meet nutritional goals. Supplemental parenteral nutrition is safe and associated with increased protein delivery. Higher protein supply is associated with good functional outcome in patients with sepsis or pneumonia.
Article
Nutrition & Dietetics
Pierre Singer, Itai Bendavid, Ronit Mesilati-Stahy, Pnina Green, Merav Rigler, Shaul Lev, Sagie Schif-Zuck, Ariel Amiram, Miriam Theilla, Ilya Kagan
Summary: The study found that combined EN and PN enriched with omega-3 PUFA did not improve lung function, but allowed for earlier weaning from catecholamine treatment and PN in critically ill patients. Supplemental PN effectively covered the energy requirements of patients.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Riccardo Caccialanza, Elena Formisano, Catherine Klersy, Virginia Ferretti, Alessandra Ferrari, Stefania Demontis, Annalisa Mascheroni, Sara Masi, Silvia Crotti, Federica Lobascio, Nadia Cerutti, Paolo Orlandoni, Cloe Dalla Costa, Elena Redaelli, Alessandra Fabbri, Alberto Malesci, Salvatore Corrao, Lorella Bordandini, Emanuele Cereda
Summary: This study investigated the association between parameters used in nutritional screening assessment (BMI, unintentional weight loss, and reduced food intake) and clinical outcomes in non-critically ill, hospitalized COVID-19 patients. The results showed that reduced self-reported food intake before hospitalization and/or expected by physicians in the next days since admission was associated with negative clinical outcomes. There was also an interaction between obesity and multiple comorbidities. This study provides a simple parameter to identify high-risk patients and deliver prompt nutritional support.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Salvatore Artale, Nunziata Grillo, Stefano Lepori, Chiara Butti, Antonella Bovio, Sabrina Barzaghi, Andrea Colombo, Elena Castiglioni, Lucia Barbarini, Laura Zanlorenzi, Paola Antonelli, Riccardo Caccialanza, Paolo Pedrazzoli, Mauro Moroni, Sabrina Basciani, Rebecca Azzarello, Francesco Serra, Alessandra Trojani
Summary: The study indicated that a Mediterranean Modified Healthy Diet (MMHD) can help reduce the risk of cancer therapy-induced diarrhea in patients with metastatic colorectal cancer, while lower levels of Vitamin D are associated with increased severity of diarrhea.
Review
Nutrition & Dietetics
Emanuele Cereda, Roberto Pisati, Mariangela Rondanelli, Riccardo Caccialanza
Summary: Sarcopenia is a muscle disease that has adverse effects on health. Treatment options include resistance exercise training and optimized protein intake using muscle-targeted oral nutritional supplementation (MT-ONS). MT-ONS has been shown to improve muscle mass, strength, and physical performance in older patients with sarcopenia.
Article
Oncology
Riccardo Caccialanza, Alessandro Laviano, Cristina Bosetti, Mariateresa Nardi, Valentina Casalone, Lucilla Titta, Roberto Mele, Giovanni De Pergola, Francesco De Lorenzo, Paolo Pedrazzoli
Summary: Malnutrition is a common problem in cancer patients, and oral nutritional supplements can effectively address this issue. However, patient access to these supplements varies and requires proper management. This review summarizes the current knowledge on the cost-effectiveness of oral nutritional supplements in actively treated cancer patients and presents the perspective of the Italian National Oncology Network.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Marianna Vitaloni, Riccardo Caccialanza, Paula Ravasco, Alfredo Carrato, Aleksandra Kapala, Marian de van der Schueren, Dora Constantinides, Eva Backman, David Chuter, Claudia Santangelo, Zorana Maravic
Summary: Nutritional intervention is crucial in cancer treatment, as it can reduce hospitalization time, improve quality of life, and prevent malnutrition. However, many European countries lack universal access to nutritional support for digestive cancer patients, highlighting the need for investment in qualified staff and resources.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Francesco Fabozzi, Chiara Maria Trovato, Antonella Diamanti, Angela Mastronuzzi, Marco Zecca, Serena Ilaria Tripodi, Riccardo Masetti, Davide Leardini, Edoardo Muratore, Veronica Barat, Antonella Lezo, Francesco De Lorenzo, Riccardo Caccialanza, Paolo Pedrazzoli
Summary: Nutritional management in pediatric cancer patients is often overlooked, and there is a lack of systematic approach. This consensus statement provides practical recommendations based on consensus to address the nutritional needs of children with cancer, filling a gap in the field.
Article
Biochemistry & Molecular Biology
Paola Zelini, Piera D'Angelo, Emanuele Cereda, Catherine Klersy, Peressini Sabrina, Riccardo Albertini, Giuseppina Grugnetti, Anna Maria Grugnetti, Carlo Marena, Sara Cutti, Daniele Lilleri, Irene Cassaniti, Baldanti Fausto, Riccardo Caccialanza
Summary: The levels of vitamin D are associated with the immune response elicited by the BNT162b2 vaccine, and adequate levels of vitamin D may improve the vaccine's effectiveness.
Article
Oncology
Riccardo Caccialanza, Emanuele Cereda, Francesco Agustoni, Catherine Klersy, Amanda Casirati, Elisabetta Montagna, Simona Carnio, Silvia Novello, Michele Milella, Sara Pilotto, Ilaria Trestini, Lucio Buffoni, Alessandra Ferrari, Paolo Pedrazzoli
Summary: This study aims to evaluate the effectiveness of early systematic provision of oral nutritional supplements (ONS) enriched with immunonutrients in patients with non-small cell lung cancer (NSCLC) receiving immunotherapy. The study will assess treatment response, treatment tolerance and toxicity, body weight, body composition, protein-calorie intake, quality of life, fatigue, muscle strength, and immunological profile.
Editorial Material
Nutrition & Dietetics
Amanda Casirati, Valentina Da Prat, Emanuele Cereda, Francesco Serra, Lorenzo Perrone, Salvatore Corallo, Francesco De Lorenzo, Paolo Pedrazzoli, Riccardo Caccialanza
Review
Environmental Sciences
Valentina Martinelli, Simran Singh, Pierluigi Politi, Riccardo Caccialanza, Andrea Peri, Andrea Pietrabissa, Matteo Chiappedi
Summary: Obesity is increasingly common among adolescents. Bariatric surgery (BS) has been shown to be an effective treatment option for severely obese adolescents, but ethical concerns and country disparities regarding this procedure remain. This review focuses on the current ethical challenges of performing BS during adolescence and proposes potential future research directions for ethical and patient-centered management of obesity in adolescents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Amanda Casirati, Alberto Somaschini, Monica Muraca, Emanuele Cereda, Vera Morsellino, Natascia Di Iorgi, Riccardo Caccialanza, Riccardo Haupt
Summary: This study aimed to evaluate the association between fat-to-lean mass ratio (FLR) and dysmetabolic profile in childhood cancer survivors (CCS). The results showed that CCS with FLR ≥0.6 were more likely to be overweight and obese and had higher levels of triglycerides, insulin resistance, and liver function, while having lower levels of insulin-like growth factor 1 and lean mass. Waist circumference, insulin-like growth factor 1, and trunk fat were independent predictors of FLR ≥0.6. It is important to maintain long-term nutritional status through diet and physical activity.
Article
Health Care Sciences & Services
Gianluca Mauri, Martino Pedrani, Silvia Ghezzi, Katia Bencardino, Sara Mariano, Erica Bonazzina, Francesco Serra, Paolo Pedrazzoli, Riccardo Caccialanza, Giulia Martina Cavestro, Salvatore Siena, Salvatore Artale, Andrea Sartore-Bianchi
Summary: Incidence of early-onset colorectal cancer (EO-CRC) is increasing, posing a clinical challenge. Clinicians tend to treat EO-CRC patients with more intensive regimens despite lack of survival benefits, based on age-related bias. Limited evidence is available regarding treatment-related toxicities in this subset of patients.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Editorial Material
Oncology
A. Casirati, V. Da Prat, E. Cereda, F. Sebastiani, I. Trestini, L. Perrone, F. Serra, M. Cintoni, P. Pedrazzoli, R. Caccialanza
Review
Nutrition & Dietetics
Sofia Matteucci, Giulia De Pasquale, Manuela Pastore, Emanuela Morenghi, Veronica Pipitone, Fanny Soekeland, Riccardo Caccialanza, Beatrice Mazzoleni, Stefano Mancin
Summary: This study provides an updated analysis on the efficacy of the low-bacterial diet (LBD) in reducing infections, mortality rates, and quality of life in neutropenic patients with cancer. The results show that LBD does not reduce infection and mortality rates and negatively impacts quality of life.
Review
Oncology
Amanda Casirati, Valentina Da Prat, Arianna Bettiga, Lucia Aretano, Francesco Trevisani, Emanuele Cereda, Alberto Briganti, Elisa Colombo, Giorgia Preziati, Francesca De Simeis, Andrea Salonia, Francesco Montorsi, Riccardo Caccialanza, Richard Naspro
Summary: Preoperative nutritional status is crucial in cancer patients undergoing radical cystectomy, as malnutrition increases the risk of post-surgical complications. Muscle mass loss, a major consequence of cancer-related malnutrition, is associated with readmission, longer hospital stays, and higher mortality rates. Immunonutrition, using specific nutrients to boost the immune system, shows promising evidence in reducing complications after bladder surgery. Further research is needed to determine the optimal approach for improving patient outcomes and establish the effectiveness of perioperative immunonutrition.