Pan-Cancer analyses of Necroptosis-Related genes as a potential target to predict immunotherapeutic outcome

Necroptosis is a unique programmed death mechanism of necrotic cells. However, its role and specific mechanism in cancer remain unclear, and a systematic pan-cancer analysis of necroptosis is yet to be conducted. Thus, we performed a specific pan-cancer analysis using The Cancer Genome Atlas and Genotype-Tissue Expression databases to analyse necroptosis expression in terms of cancer prognosis, DNA methylation status, tumour mutative burden, microsatellite instability, immune cell infiltration in different types of cancer and molecular mechanisms. For the first time, we explored the correlation between necroptosis and immunotherapy prognosis. Thus, our study provides a relatively comprehensive understanding of the carcinogenicity of necroptosis in different types of cancer. It is suggested that necroptosis can be used to evaluate the sensitivity of different patients to immunotherapy and may become a potential target for tumour immunotherapy.

Automated summary

In this study, a systematic analysis of the necroptosis mechanism in cancer was conducted using The Cancer Genome Atlas and Genotype-Tissue Expression databases. The results revealed the correlation between necroptosis and cancer prognosis, DNA methylation status, tumour mutative burden, microsatellite instability, immune cell infiltration, and explored the relationship between necroptosis and immunotherapy prognosis for the first time. This study provides important evidence for a comprehensive understanding of the carcinogenicity of necroptosis in different types of cancer and suggests that necroptosis can be used as a potential target for tumor immunotherapy.