Phosphorylation alters the mechanical stiffness of a model fragment of the dystrophin homologue utrophin

Utrophin modulator drugs as potential therapies for Duchenne and Becker muscular dystrophies

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SuperPlots: Communicating reproducibility and variability in cell biology

(2020) Samuel J. Lord et al.   JOURNAL OF CELL BIOLOGY

Micro-utrophin Therapy for Duchenne Muscular Dystrophy

(2019) Dongsheng Duan   MOLECULAR THERAPY

Micro-Dystrophin Gene Therapy Goes Systemic in Duchenne Muscular Dystrophy Patients

(2018) Dongsheng Duan   HUMAN GENE THERAPY

Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins

(2018) D’anna M Nelson et al.   HUMAN MOLECULAR GENETICS

Syntrophin binds directly to multiple spectrin-like repeats in dystrophin and mediates binding of nNOS to repeats 16–17

(2018) Marvin E Adams et al.   HUMAN MOLECULAR GENETICS

The potential of utrophin modulators for the treatment of Duchenne muscular dystrophy

(2018) Simon Guiraud et al.   Expert Opinion on Orphan Drugs

Dystrophin As a Molecular Shock Absorber

(2018) Shimin Le et al.   ACS Nano

Mechanical forces during muscle development

(2017) Sandra B. Lemke et al.   MECHANISMS OF DEVELOPMENT

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

(2017) Adam W. Avery et al.   Nature Communications

Safety, Tolerability, and Pharmacokinetics of SMT C1100, a 2-Arylbenzoxazole Utrophin Modulator, following Single- and Multiple-Dose Administration to Pediatric Patients with Duchenne Muscular Dystrophy

(2016) Valeria Ricotti et al.   PLoS One

Phosphorylation regulates IDP folding

(2015) Katharine H. Wrighton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts

(2013) Sebastian Kötter et al.   CARDIOVASCULAR RESEARCH

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

(2013) Yangyang Bian et al.   Journal of Proteomics

Evidence-based path to newborn screening for duchenne muscular dystrophy

(2012) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells

(2012) Giorgio Fois et al.   FASEB JOURNAL

Internal deletion compromises the stability of dystrophin

(2011) Davin M. Henderson et al.   HUMAN MOLECULAR GENETICS

Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: Mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics

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Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

A Two-amino Acid Mutation Encountered in Duchenne Muscular Dystrophy Decreases Stability of the Rod Domain 23 (R23) Spectrin-like Repeat of Dystrophin

(2009) Sébastien Legardinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

(2009) Yi Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

(2008) Darko Bosnakovski et al.   EMBO JOURNAL

A quantitative atlas of mitotic phosphorylation

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