Review
Ophthalmology
Amit K. Reddy, Jason R. Kolfenbach, Alan G. Palestine
Summary: This article summarizes the pathophysiology of rheumatoid arthritis and its common ocular manifestations, introduces newer biologic agents for effective treatment, and emphasizes the importance of coordination between ophthalmology and rheumatology in patient care.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Review
Medicine, General & Internal
Ken Fukuda, Tomoka Mizobuchi, Isana Nakajima, Tatsuma Kishimoto, Yusaku Miura, Yoshinori Taniguchi
Summary: Relapsing polychondritis (RPC) is a rare systemic immune-mediated disease characterized by recurrent inflammation of cartilaginous and proteoglycan-rich tissues. Ocular tissues are also targets of inflammation in RPC, affecting approximately half of the patients. Physicians should be vigilant of RPC when encountering patients with recurrent ocular inflammation and various systemic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Benjamin Clarke, Mark Yates, Maryam Adas, Katie Bechman, James Galloway
Summary: As efficacy and safety data emerge, differences between JAK inhibitor subclasses are becoming evident. It is too early to conclude on distinct safety profiles between JAK1 selective agents and other JAK inhibitors, with further research needed for support. Monitoring infection risk, laboratory abnormalities, and herpes zoster reactivation are important considerations when using JAK inhibitors.
Review
Ophthalmology
Masaru Miyanaga, Hiroshi Takase, Kyoko Ohno-Matsui
Summary: This study investigated ocular manifestations in patients positive for serum anti-neutrophil cytoplasmic antibodies (ANCAs) in Japan. The results showed that optic nerve involvement, scleritis, and iritis were common ocular manifestations among these patients, with most optic nerve involvement patients being myeloperoxidase-ANCA positive, and most anterior segment involvement patients being proteinase-3-ANCA positive. Serum ANCA evaluation is helpful in identifying the etiology of ocular inflammation and diagnosing ANCA-associated vasculitis, a life-threatening disease.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Review
Biochemistry & Molecular Biology
Lavinia Agra Coletto, Chiara Rizzo, Giuliana Guggino, Roberto Caporali, Stefano Alivernini, Maria Antonietta D'Agostino
Summary: Spondyloarthritis (SpA) is a group of inflammatory diseases that affect the musculoskeletal system, gut, skin, and eyes. Neutrophils have emerged as crucial cells in orchestrating the pro-inflammatory response in SpA, playing a significant role in inflammation initiation, amplification, and structural damage occurrence. This review aims to explore the functions and abnormalities of neutrophils in each disease domain of SpA, highlighting their potential as biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Rosanna Dammacco, Luca Cimino, Luca De Simone, Giovanni Alessio, Franco Dammacco
Summary: Eye involvement is common in patients with cryoglobulinemic vasculitis (CV), and various treatment approaches can improve symptoms and enhance visual acuity.
Article
Medicine, General & Internal
Yutaka Kaneko, Takanori Murakami, Koichi Nishitsuka, Yuya Takakubo, Michiaki Takagi, Hidetoshi Yamashita
Summary: Baricitinib is an effective treatment option for refractory rheumatoid arthritis and uveitis, as it can decrease inflammatory activity and improve symptoms in both conditions.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Ji Wen, Huifang Hu, Menglin Chen, Hang Yang, Yi Zhao, Yi Liu
Summary: This study evaluated the effectiveness of JAK inhibitors in treating autoimmune ocular inflammation, finding that all 11 patients who were refractory to conventional treatments showed improvement with JAK therapy without significant side effects. Different types of JAK inhibitors may have varying responses in treating ocular inflammation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shoko Saito, Hiroshi Keino, Ichiro Takasaki, Shinya Abe, Hideo Kohno, Kousuke Ichihara, Isami Hayashi, Makiko Nakayama, Yukihiro Tsuboshita, Sawako Miyoshi, Susumu Okamoto, Annabelle A. Okada
Summary: This study investigated the serum miRNA profiles of patients with ocular sarcoidosis and idiopathic uveitis characterized by ocular manifestations of sarcoidosis. The results showed distinct differences in serum miRNA expression between diagnosed ocular sarcoidosis and suspected ocular sarcoidosis patients, but the patterns were highly similar. Common pathways, including WNT signaling and TGF-beta signaling, were found to be involved in both groups. This suggests that these two conditions may share a similar underlying pathology and represent possible variants of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Hnin Hnin Oo, Mun Yoong Darren Choy, Atul Arora, See Cheng Yeo, Raja Ramachandran, Vishali Gupta, Peter McCluskey, Rupesh Agrawal
Summary: Immunoglobulin A nephropathy (IgAN) is a rare but important systemic disease that may present with ocular manifestations. This study describes cases of IgAN with scleritis and reviews various ocular manifestations in IgAN patients. A total of 55 cases with ocular manifestations in IgAN patients were identified from 38 publications. The most common ocular manifestations were episcleritis, scleritis, hypertensive retinopathy or retinal vasculopathy, and uveitis. Timely recognition and co-management with a nephrologist can reduce disease morbidity.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Leslie Rebibo, Connie Tam, Yan Sun, Eve Shoshani, Amit Badihi, Taher Nassar, Simon Benita
Summary: The study confirmed the stability and efficacy of tacrolimus-loaded nanocapsules in ocular applications. NCs showed superior performance in eye instillation, leading to high levels of tacrolimus retention in the eye and low plasma concentrations. Additionally, the developed delivery system achieved a significant decrease in inflammatory markers in murine models of keratitis and experimental autoimmune uveitis, demonstrating clinical and histological efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Gastroenterology & Hepatology
Janaki Shah, Aaditya Shah, Lynn Hassman, Alexandra Gutierrez
Summary: IBD is not only associated with intestinal inflammation, but can also manifest in ocular symptoms such as keratopathy. Investigating and treating ocular symptoms in IBD patients is crucial in preventing ocular complications.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Rheumatology
Philip J. Mease, Mohit Kumar Bhutani, Steven Hass, Esther Yi, Peter Hur, Nina Kim
Summary: The study evaluated the clinical manifestations of SpA and RA patients to understand the potential overlap and differences in accurate diagnosis. Advanced imaging techniques can aid in distinguishing between SpA and RA, but challenges in accurately identifying SpA still exist in some cases.
RHEUMATOLOGY AND THERAPY
(2022)
Review
Ophthalmology
Shokufeh Tavassoli, Nathan Wong, Elsie Chan
Summary: Ocular rosacea is a chronic inflammatory condition that primarily affects the eyes with symptoms such as chronic blepharoconjunctivitis and meibomian gland dysfunction. Corneal complications can include vascularization, ulceration, and scarring, and treatment options vary depending on disease severity. Ocular rosacea can also be associated with systemic disorders like cardiovascular disease.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Microbiology
Mengyao Li, Li Yang, Liangliang Zhao, Feng Bai, Xiaoli Liu
Summary: We compared intestinal microbes in anterior noninfectious scleritis patients with and without rheumatoid arthritis. The study found a significant decrease in species richness in patients with rheumatoid arthritis. At the genus level, there were more enriched and decreased microbes in the rheumatoid arthritis group compared to the non-rheumatoid arthritis group. Four microbes were enriched in both groups and showed positive correlations. Additionally, nine microbes were decreased in the rheumatoid arthritis group, indicating a potential protective role in the pathogenesis of scleritis.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.