Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 20, Issue 2, Pages 225-231Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.80262
Keywords
Pbx1; Development; Regenerative medicine; Transcription factors
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This article reviews the research progress on PBX1 in terms of structure, developmental function, and regenerative medicine. It also suggests a possible link between PBX1 in the two domains, which would provide a new target for the study of diseases in various systems.
Pre-B-cell leukemia transcription factor 1 (PBX1) proteins are a subfamily of evolutionarily conserved atypical homeodomain transcription factors belonging to the superfamily of triple amino acid loop extension homeodomain proteins. PBX family members play crucial roles in the regulation of various pathophysiological processes. This article reviews the research progress on PBX1 in terms of structure, developmental function, and regenerative medicine. The potential mechanisms of development and research targets in regenerative medicine are also summarized. It also suggests a possible link between PBX1 in the two domains, which is expected to open up a new field for future exploration of cell homeostasis, as well as the regulation of endogenous danger signals. This would provide a new target for the study of diseases in various systems.
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