4.7 Article

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 23, Pages 11743-11750

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02211

Keywords

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Funding

  1. National Natural Science Foundation of China [21332005, 21472085]
  2. Qing Lan Project

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The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO3 as an inexpensive catalyst at levels as low as 1.0 mol %. Investigation of the mechanism indicates a catalytic cycle involving a radical process.

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