Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 19, Pages 8934-8946Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b01609
Keywords
-
Categories
Funding
- JSPS
- MEXT KAKENHI [15K07862, 26105746]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [26105746, 15K07862, 16K08167] Funding Source: KAKEN
Ask authors/readers for more resources
The catalytic deuterodechlorination of aryl/heteroaryl chlorides was developed with a palladium/unsymmetrical NHC system, and the precisely controlled introduction of deuterium into a variety of aryl/heteroaryl compounds was achieved with a high level of efficiency, selectivity, and deuteration degree. This method was also successfully applied to the transformation of bioactive agents even in a gram-scale synthesis. The crystal structure analysis of Pd-HC complexes led to the observation of Pd-arene interaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available