Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 5, Pages 2194-2200Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00022
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- U.S. National Institutes of Health [U54 MH084512-05-21755, R01 DA035056, R01 CA154739]
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Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure-activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.
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