Cp*Co(III)-Catalyzed C-H/N-N Functionalization of Arylhydrazones for the Synthesis of Isoquinolines

Cationic Co(III)-catalyzed C-H/N-N bond functionalization of arylhydrazones with internal alkynes has been developed for the, synthesis of isoquinoline derivatives. The arylhydrazones are easy to prepare and require inexpensive and commercially available hydrazine hydrate. The reaction works well with a variety of internal alkynes and arylhydrazones and Offers broad scope, good functional group tolerance, and high yields under redox-neutral conditions in the presence of air.