4.7 Article

Broad Scope Aminocyclization of Enynes with Cationic JohnPhos-Gold(I) Complex as the Catalyst

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 5, Pages 1839-1849

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b02607

Keywords

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Funding

  1. European Research Council [321066]
  2. MINECO [CTQ2013-42106-P]
  3. European Research Council (ERC) [321066] Funding Source: European Research Council (ERC)

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A practical aminocyclization of 1,6-enynes with a wide variety of substituted anilines, including N-alkyl anilines, has been achived by using cationic [JohnPhosAu(MeCN)]SbF6 as a general purpose catalyst. The resulting adducts can be easily converted into polycyclic compounds by palladium- and gold-catalyzed reactions.

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