Journal
HYPERTENSION RESEARCH
Volume 46, Issue 3, Pages 556-564Publisher
SPRINGERNATURE
DOI: 10.1038/s41440-022-01135-4
Keywords
Urinary Na; K ratio; Hypertension; Habitual diet; Milk
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The association between the urinary sodium/potassium ratio and hypertension was explored in older adults living in a community in Japan. The study found that the ratio was independently associated with systolic blood pressure, education level, number of cohabitants, estimated glomerular filtration rate, and depression score. Dietary patterns, specifically milk consumption and frequency of fruit and vegetable consumption, also influenced the ratio. The results highlight the importance of nutritional education in preventing hypertension.
The association between the urinary sodium (Na)/potassium (K) ratio and hypertension is well recognized. We investigated whether the urinary Na/K ratio might be associated with hypertension in community-dwelling older adults and whether the association was influenced by habitual dietary patterns. We enrolled a total of 684 older adults (mean age, 76.8 years) and conducted health examinations at Kusatsu, Japan, in 2021. The urinary Na/K ratio was found to be independently associated with systolic blood pressure (SBP) (p < 0.0001), years of education (p = 0.0027), number of cohabitants (p = 0.0175), estimated glomerular filtrate rate (eGFR) (p = 0.0244), and Geriatric Depression Scale short-version (GDS15) score (p = 0.0366). In addition, an unsupervised hierarchical clustering analysis revealed a spectrum of habitual dietary patterns for higher and lower values of the urinary Na/K ratio. The decision tree indicated that the urinary Na/K ratio was associated with the history of milk consumption. A positive history of daily milk consumption predicted a mean urinary Na/K ratio of 2.8, and a negative history of daily milk consumption predicted a mean urinary Na/K ratio of 3.3. Furthermore, the frequency of fruit and vegetable consumption also predicted the urinary Na/K ratio. The relationship between the urinary Na/K ratio and hypertension was influenced by the frequency of consumption of milk, fruits, and vegetables in the subjects. This finding might be due to the influence of education and/or depression. The results suggested the importance of nutritional education in the development of hypertension.
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