Article
Oncology
Alexandra Diggs, Tiffany Y. Sia, Yongmei Huang, Allison Gockley, Alexander Melamed, Fady Khoury-Collado, Caryn St. Clair, June Y. Hou, Dawn L. Hershman, Jason D. Wright
Summary: This study analyzed the utilization of adjuvant chemotherapy and radiation therapy in patients with stage II and III uterine leiomyosarcoma (uLMS). The results showed that the use of chemotherapy is increasing while the use of radiation therapy is decreasing. Radiation therapy is associated with improved survival in both stage II and III disease, but there is no association between adjuvant chemotherapy and survival in stage II patients.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Julia Dexter, Erin Lips, Paul DiSilvestro
Summary: This review explores the historical literature on adjuvant treatment in endometrial cancer and the ongoing debate over the optimal use of chemotherapy and radiotherapy. It also discusses recent findings on molecular classification and prognostic implications in the field of genomic medicine. While most endometrial cancer patients have a good prognosis, adjuvant treatment can improve outcomes for advanced-stage and high-risk histologies. The optimal treatment modality/modalities continue to be debated, especially with the advancements in molecular treatment for endometrial cancer.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Shao-Jing Wang, Lily Wang, Lou Sun, Yu-Hsiang Shih, Shih-Tien Hsu, Chin-Ku Liu, Sheau-Feng Hwang, Chien-Hsing Lu
Summary: Postoperative sandwich chemoradiotherapy appears to be more effective than chemotherapy alone in terms of 5-year disease-specific survival and local control for stage III endometrial cancer patients, with tolerable toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Xi-Lin Yang, Feng-Leng Yang, Ling-Na Kou, Da-Jun Wu, Cong Xie
Summary: A nomogram was developed to predict the survival of stage IIIC endometrial cancer patients who received adjuvant radiotherapy (ART) alone. The low-risk patients may not need adjuvant chemotherapy, while the middle- and high-risk patients could benefit from it.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
D. Forsse, H. F. Berg, O. Bozickovic, H. Engerud, M. K. Halle, E. A. Hoivik, K. Woie, H. M. J. Werner, I. S. Haldorsen, J. Trovik, C. Krakstad
Summary: The study found that in the treatment of endometrial cancer, an appropriate lymphadenectomy rate is around 50%, and adjuvant chemotherapy may perform equally to adjuvant radiotherapy, potentially being superior for advanced stage patients.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Hsiu-Jung Tung, Huei-Jean Huang, Chyong-Huey Lai
Summary: Endometrial cancer is usually diagnosed as a localized or regional disease, with treatment options including surgery and adjuvant therapy. Risk group classification plays an important role in guiding the selection of adjuvant therapy.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Oncology
Divya Yerramilli, Yu-Hui Chen, Veena Venkatachalam, Gabriela M. Alban, Daniela L. Buscariollo, Teresa Cheng, Martin T. King, Jennifer L. Pretz, Andrea L. Russo, Larissa J. Lee
Summary: This study analyzed survival outcomes and sites of failure for patients with FIGO stage IIIC endometrioid endometrial cancer treated with pelvic radiation therapy (PRT) versus extended-field radiation therapy (EFRT). The study found that isolated para-aortic relapse outside the PRT field was uncommon and amenable to salvage therapy for patients with positive pelvic nodes.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Amy Jamieson, Jutta Huvila, Samuel Leung, Derek Chiu, Emily F. Thompson, Amy Lum, Mary Kinloch, Limor Helpman, Shannon Salvador, Danielle Vicus, Sarah Kean, Vanessa Samouelian, Katherine Grondin, Julie Irving, Saul Offman, Carlos Parra-Herran, Susie Lau, Stephanie Scott, Marie Plante, Melissa K. McConechy, David G. Huntsman, Aline Talhouk, Stefan Kommoss, C. Blake Gilks, Jessica N. McAlpine
Summary: The clinical outcomes of endometrial cancer (EC) patients vary according to different molecular subtypes and adjuvant treatments. For MMRd EC patients, there is no significant benefit in DSS or PFS with the addition of chemotherapy +/- radiation compared to radiation alone. However, for p53abn EC patients, adjuvant chemotherapy given with radiation is associated with significantly longer DSS, even in stage I disease and non-serous histotypes.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Peiying Fu, Haiying Sun, Ting Zhou, Pengfei Cui, Shixuan Wang, Ronghua Liu
Summary: This study found that postoperative adjuvant therapy did not significantly improve disease-free survival or overall survival in patients with early stage endometrial cancer. However, cancer stage and age had a significant impact on survival in patients with stage I endometrial cancer.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Oncology
He Huang, Yan-Ling Feng, Ting Wan, Yan-Na Zhang, Xin-Ping Cao, Yong-Wen Huang, Ying Xiong, Xin Huang, Min Zheng, Yan-Fang Li, Jun-Dong Li, Guan-Di Chen, Hu Li, Yi-Le Chen, Li-Guo Ma, Hong-Ying Yang, Li Li, Shu-Zhong Yao, Wei-Jun Ye, Hua Tu, Qi-Dan Huang, Li-Zhi Liang, Fu-Yuan Liu, Qing Liu, Ji-Hong Liu
Summary: In this study, SCRT showed better disease-free survival and lower risk of cancer death compared to CCRT and RT in postoperative adjuvant treatment of early-stage cervical cancer.
Article
Medicine, Research & Experimental
Cecilia Villegas, Rebeca Perez, Olov Sterner, Ivan Gonzalez-Chavarria, Cristian Paz
Summary: Colorectal cancer is the second leading cause of cancer death worldwide, mainly affecting men, with about 20% of cases due to hereditary syndromes. Curcumin, the main polyphenol pigment in turmeric, has antioxidant properties and synergistic effects with both anticancer and anti-inflammatory drugs in inhibiting the progression of CRC through multiple signaling pathways.
Article
Oncology
Christian Domroese, Peter Mallmann
Summary: This article presents the adjuvant treatment options (chemotherapy and radiotherapy) for primary endometrial cancer, based on a selective literature search and the new German S3 guideline.
Article
Oncology
Neelima Denduluri, Mark R. Somerfield, Mariana Chavez-MacGregor, Amy H. Comander, Zoneddy Dayao, Andrea Eisen, Rachel A. Freedman, Ragisha Gopalakrishnan, Stephanie L. Graff, Michael J. Hassett, Tari A. King, Gary H. Lyman, Gillian Rice Maupin, Raquel Nunes, Cheryl L. Perkins, Melinda L. Telli, Maureen E. Trudeau, Antonio C. Wolff, Sharon H. Giordano
Summary: The study recommends offering 14 cycles of adjuvant T-DM1 to patients with HER2-positive breast cancer with pathologic invasive residual disease after standard preoperative chemotherapy and HER2-targeted therapy, based on the results of the KATHERINE trial.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Oncology
Isao Otsuka
Summary: Pelvic lymphadenectomy is not therapeutic but can be beneficial in certain cases. For intermediate- and high-risk endometrioid endometrial carcinomas, adjuvant therapy can be safely omitted if patients are node-negative and undergo systematic lymphadenectomy, without decreasing long-term survival.
Article
Oncology
Aaron M. Praiss, Yongmei Huang, Caryn M. St Clair, Alexander Melamed, Fady Khoury-Collado, June Y. Hou, Allison Gockley, Grace C. Hillyer, Dawn L. Hershman, Jason D. Wright
Summary: The study found that the use of TVH for early-stage endometrial cancer patients in the U.S. has decreased, with age being the primary factor influencing the performance of TVH. TVH does not negatively impact cancer-specific survival compared to TLH.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)