Article
Neurosciences
Chong Li, Mingyu Sun, Shiliu Tian
Summary: Transcranial magnetic stimulation (TMS) is a safe and non-invasive method for pain therapy. This study used bibliometric analysis to explore the research hotspots and discovery process in TMS for pain research. The findings suggest that further large-sample, randomized controlled trials are needed to validate the effectiveness of different TMS parameters in pain research.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Environmental Sciences
Qianyu Sun, Boshen Wang, Shouxiang Xu, Xiaowei Cong, Yuepu Pu, Juan Zhang
Summary: This study extracted the trend of benzene-induced leukemia (BIL) and qualitatively and quantitatively estimated research on it. The results showed that there were a significant number of publications on BIL, with the United States leading in research contributions. Chinese institutions also made a significant contribution to this field. The research hotspots mainly focused on the exposure population, exposure dose, and exposure risk. Future research may focus on early, sensitive, and specific epigenetic biomarkers of benzene-induced leukemia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Neurosciences
Chenchen Zhu, Weiquan Zhong, Chan Gong, Binglin Chen, Jiabao Guo
Summary: This study visually analyzed the trends, hotspots, and frontiers in epigenetics and neuropathic pain (NP) research using bibliometric tools. The analysis revealed an increasing number of publications in this field, with DNA methylation, Circular RNA, acetylation, long non-coding RNA, and microglia being identified as global hotspots. Rigorous clinical trials and further studies on relevant mechanisms are needed in the future.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Hongbo Chen, Yiwei Luo, Xiaohong Zhang, Ruzhen Luo, Yuhong Bian, Yunlong Hou, Yanhui Liu
Summary: Immunosenescence, an age-related deficit in immunity, is associated with multiple disorders. Through a comprehensive bibliometric analysis of nearly 4000 articles, it was found that the research on immunosenescence is continuously growing and the hotspots mainly focused on gut microbiota, health, dysfunction, and nivolumab. Collaboration with research teams from the USA or Germany may be the best choice. Mechanisms and interventions like gut microbiota and nivolumab have great potential in immunosenescence research and clinical application.
Article
Cell Biology
Xueying Huang, Zhiying Yang, Jinning Zhang, Ruojiao Wang, Jiahui Fan, Heng Zhang, Rong Xu, Xia Li, Siying Yu, Linna Long, He Huang
Summary: The research on SMAD7 in oncology is rapidly increasing, with notable contributions from China, the United States, and Germany. Multilateral cooperation among institutions or investigators is beneficial for high-quality outputs, and PPAR-gamma shows potential as a future research focus.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Toxicology
Jingying Wu, Qing Liu, Shile Wang, Jinfang Sun, Ting Zhang
Summary: This paper explores the current research status, hot topics, and future prospects in the field of graphene and its derivatives toxicity. The study provides a visual analysis of the research conducted in the last 10 years and identifies the characteristics, distribution of authors and institutions, popular keywords, and frontier topics in this field.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Review
Psychology, Multidisciplinary
Hongchun Xiang, Jing Li, Bocun Li, Qian Tan, Guowei Cai
Summary: This study analyzed the current status and trends of acupuncture for depression in the last decade, identifying China and KyungHee University as the most prolific country and institution, and the journal Evidence-based Complementary and Alternative Medicine as the most prolific and cited journal in this field. The keyword "cognitive behavioral therapy" showed the highest citation burst in research developments, and the hot topics in acupuncture for depression included acupuncture, depression, electro-acupuncture, quality of life, and anxiety.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Medicine, General & Internal
Yuerong Chen, Yunyun Xu, Jiale Dai, Wenqin Ni, Qike Ding, Xinyuan Wu, Jianqiao Fang, Yuanyuan Wu
Summary: The study reveals a significant increase in research on chemogenetics in neuroscience over the past 14 years. The application of chemogenetics is crucial for neuroscience research, and certain hot topics have gained more attention, such as transgenic mice, cancer, and the blood-brain barrier.
Article
Clinical Neurology
Youjie Zeng, Si Cao, Heng Yang
Summary: This study conducted a bibliometric analysis to explore the impact of COVID-19 on stroke and identified the major research trends in this field. The results showed that JOURNAL OF STROKE and CEREBROVASCULAR DISEASES published the most studies, while STROKE had the most-cited references. The United States was the most influential country, with the highest number of publications and citations. Three major research topics were identified, including the impact of COVID-19 on stroke outcomes, the management and care of stroke patients during the pandemic, and the potential relationship and pathological mechanism between COVID-19 and stroke. The study provides a comprehensive overview of the current state of research on COVID-19 and stroke.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Chong Li, Shuting Tu, Shuo Xu, Yongli Zhang, Zhijie Yan, Jie Jia, Shiliu Tian
Summary: This bibliometric study investigates the global hotspots and frontiers of transcranial direct current stimulation (tDCS) in stroke from 2012 to 2021. The results show an increasing number of publications in this field, with neuroscience being the main research hotspot. The study also highlights the focus on post-stroke aphasia, tDCS combined with robotic therapy, and anatomical parameters in current research.
Article
Clinical Neurology
Kebing Zhou, Yu Zhou, Yuena Zeng, Jiahui Zhang, Xiaoyan Cai, Jieying Qin, Zhiying Li, Fengxia Yan
Summary: This study aimed to conduct a bibliometric analysis of scientific literature on the use of transcranial direct current stimulation in stroke treatment. The results showed that the USA had the highest number of publications, with Harvard Medical School and Fregni F being the top institutions and authors respectively. The research topics can be categorized into three sections: treatment mechanisms, comparison with transcranial magnetic stimulation, and clinical application in post-stroke dysfunction. Walking, strength, and virtual reality therapy were identified as future research hotspots for transcranial direct current stimulation.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Pharmacology & Pharmacy
Zhaomeng Hou, Ping Jiang, Shaoting Su, Honghai Zhou
Summary: This study explores the research hotspots and trends of multiple myeloma bone disease in the past 20 years through bibliometric visualization analysis, revealing that the research is mainly focused on oncology and hematology, with recent frontiers in disease diagnosis, prognosis evaluation, pathogenesis, imaging technology, and targeted therapy. Burst keywords like transplantation, progression, activation, lenalidomide, flow cytometry, drug resistance, management, and mesenchymal stem cell reflect the latest research hotspots.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Green & Sustainable Science & Technology
Yongjiang Hou, Zheng Shen
Summary: This article provides a review and summary of research in the field of ozone pollution through bibliometric analysis and visualization tools. It identifies the main focus areas and emerging hotspots in the field, and highlights the application of artificial intelligence in ozone pollution research.
Article
Integrative & Complementary Medicine
Danchun Lan, Cheng Huang, Na Yu, Jinxiong Lao, Ziyong Li
Summary: This study used bibliometric approaches to assess global scientific achievements in acupuncture for facial paralysis research, identified hotspots and trends, and provided guidance for further research in the field.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Review
Psychology, Multidisciplinary
Li Fei, Xizhen Kang, Weiming Sun, Boxiang Hu
Summary: This study utilized CiteSpace to analyze the current situation of first-generation college students field and identify the research hotspots and frontiers. The growing global trends in first-generation college students research and increasing public awareness of academic performance and equality suggest that further breakthroughs in this field are expected in the future.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Chemistry, Physical
Jingjing Song, Shaomian Liu, Yongjun Ji, Wenqing Xu, Jian Yu, Bing Liu, Wenxing Chen, Jianling Zhang, Lihua Jia, Tingyu Zhu, Ziyi Zhong, Guangwen Xu, Fabing Su
Summary: The dual single-atom Ce-Ti/MnO2 catalyst prepared via ball-milling and calcination processes exhibited better catalytic performance at low temperatures, with higher NO conversion and enhanced resistance to H2O and SO2.
Article
Chemistry, Multidisciplinary
Lei Li, Jing-jing Song, Meng-xue Zhang, Hui-wen Zhang, Hai-yan Zhu, Wei Guo, Cai-long Pan, Xue Liu, Lu Xu, Zhi-yuan Zhang
Summary: This study demonstrates that oridonin has a protective effect against neuronal loss caused by ischemic stroke, and this protection is achieved by inhibiting excessive autophagy signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biology
Jingxuan Xu, Jingjing Song, Xinxin Chen, Yingpeng Huang, Tao You, Ce Zhu, Xian Shen, Yaping Zhao
Summary: This study identified a 12-miRNA signature associated with genomic instability for predicting gastric cancer prognosis. The researchers constructed a miRNA signature scheme based on the TCGA dataset and analyzed the potential biological pathways associated with genomic instability-related miRNAs. Additionally, miR-100-5p and miR-145-3p were found to promote gastric cancer cell growth, invasion, and migration.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yujun Zhang, Jingjing Song, Yiwei Zhang, Ting Li, Jie Peng, Haonan Zhou, Zhen Zong
Summary: Neutrophil extracellular traps (NETs) are fibrous networks consisting of chromatin DNA and antimicrobial proteins. They are secreted by activated neutrophils and play crucial roles in host defense and immune responses. Research shows that NETs contribute significantly to the progression and metastasis of gastrointestinal malignancies, including gastric, colon, liver, and pancreatic cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Weiming Sun, Guanxiu Liu, Xiangli Dong, Yang Yang, Guohua Yu, Xing Sun, Zhen Feng, Chaolin Ma
Summary: This study found that transcranial direct current stimulation (tDCS) improves some neurophysiological parameters but does not change the clinical outcomes of disorders of consciousness (DOC) patients after traumatic brain injury (TBI).
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Hexu Han, Ting Lin, Zhenyu Wang, Jingjing Song, Ziyi Fang, Jing Zhang, Xiaomin You, Yanping Du, Jun Ye, Guoxiong Zhou
Summary: The study investigated the role of RNA-binding motif 4 (RBM4) in angiogenesis in hepatocellular carcinoma (HCC). It was found that RBM4 expression was correlated with tumor microvessel density and the expression of proangiogenic factor VEGF-A. Mechanistically, RBM4 mediated its effects through the NF-kB signaling pathway. These findings suggest that RBM4 plays a crucial role in promoting angiogenesis in HCC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Virology
Mengdong Wang, Jingjing Song, Chao Gao, Cuilian Yu, Chao Qin, Yue Lang, Aotian Xu, Yun Liu, Wenhai Feng, Jun Tang, Rui Zhang
Summary: The DNA methylation regulator UHRF1 is found to be a potent negative regulator of IFN-I induction during alphaherpesvirus infection. Knockdown of UHRF1 in cells increases IFN-beta-mediated gene transcription and antiviral inhibition. UHRF1 deficiency promotes IFN-I production by triggering dsRNA-sensing receptor RIG-I and activating IRF3 phosphorylation.
JOURNAL OF VIROLOGY
(2023)
Correction
Oncology
Zhiping Li, Hui Bi, Hongbo Jiang, Jingjing Song, Qingfan Meng, Yizhi Zhang, Xiaofang Fei
MOLECULAR MEDICINE REPORTS
(2023)
Article
Endocrinology & Metabolism
Jun Wen, Qi Pan, Lei-Lei Du, Jing-Jing Song, Yu-Peng Liu, Xiang-Bin Meng, Kuo Zhang, Jun Gao, Chun-Li Shao, Wen-Yao Wang, Hao Zhou, Yi-Da Tang
Summary: This study aims to evaluate the association between the TyG index and glucose metabolic indicators, insulin resistance, and the risk of ASCVD and mortality among FH patients. The results show that the TyG index is positively associated with various glucose metabolism-related indicators and insulin resistance. A higher TyG index is independently associated with an increased risk of ASCVD and mortality among FH patients.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Plant Sciences
Leiting Li, Jingjing Song, Meiling Zhang, Shahid Iqbal, Yuanyuan Li, Heng Zhang, Hui Zhang
Summary: We generated a high-quality assembly of the chia genome using PacBio's circular consensus sequencing (CCS) technology, which includes six chromosomes composed of 21 contigs with a total length of 361.7Mb. Genome annotation revealed a 53.5% repeat content and 35,850 protein-coding genes. We identified candidate fatty acid desaturases responsible for alpha-linolenic acid (ALA) biosynthesis in chia seeds using the reference genome and two transcriptome datasets. This genome assembly will serve as a valuable resource for breeding, comparative genomics, and functional genomics studies of chia.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Psychiatry
Xiangli Dong, Yuchen Zou, Qing Zou, Na Zhao, Shilin Li, Guanxiu Liu, Maorong Hu, Weiming Sun
Summary: This study used bibliometric analysis to provide an overview of the current research status and highlight hotspots and cutting-edge issues in the field of Non-suicidal Self-injury (NSSI). The results showed that the USA and Harvard University were the most productive country and institution. Psychiatry Research was the most productive journal, and Michael Kaess and Matthew K. Nock were the most influential authors.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Cell & Tissue Engineering
Xiao-Qian Shan, Yong-Yin Luo, Jun Chang, Jing-Jing Song, Nan Hao, Lan Zhao
Summary: There is a lack of ideal prevention and treatment measures for ischemic stroke (IS), but transplantation therapy of mesenchymal stem cells (MSCs) has shown promise. However, risks associated with this cell therapy exist. MSC-derived exosomes (MSC-Exos) has emerged as a potential alternative, as it avoids the risks and difficulties of cell therapy. Suppressing inflammation via modulation of the immune response is another treatment option for IS, and MSC-Exos play a role in modulating the inflammatory immune response.
WORLD JOURNAL OF STEM CELLS
(2023)
Article
Biochemistry & Molecular Biology
Tong Zhu, Jingjing Song, Bin Gao, Junjie Zhang, Yabei Li, Zhaoyang Ye, Yuxiang Zhao, Xiaogang Guo, Feng Xu, Fei Li
Summary: In this study, the effect of extracellular matrix (ECM) stiffness on the efficacy of candesartan (CAN) in anti-fibrosis and antioxidant treatment was investigated. The results showed that CAN had the best improvement efficacy in rats with medium-stiffness myocardial tissue. Cell culture substrates mimicking the ECM stiffness of cardiac fibroblasts (CFs) at different stages of myocardial fibrosis were used to study the effects of ECM stiffness on CFs, and it was found that CAN had the most significant anti-fibrosis and antioxidant efficacy on medium-stiffness substrates.
Article
Psychology, Multidisciplinary
Weiming Sun, Xizhen Kang, Xiangli Dong, Zijian Zeng, Qing Zou, Meixiang Su, Ke Zhang, Guanxiu Liu, Guohua Yu
Summary: Postpartum depression is a complex combination of physiological, emotional, and behavioral alterations associated with postpartum chemical, social, and psychological variations. Standard depression treatments are not ideal for PPD, but transcranial direct current stimulation (tDCS) is an emerging technology that can provide safe and non-pharmacological treatment. tDCS can relieve depression by directly stimulating the prefrontal cortex and indirectly promoting the release of neurotransmitter GABA. However, its effectiveness in treating PPD needs further study.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Education, Scientific Disciplines
Weiming Sun, Xiangli Dong, Guohua Yu, Yang Yang, Binjun He, Yingming Wei, Shijin Li, Zhen Feng, Chaolin Ma
Summary: This study has successfully developed a behavioral assessment scale for measuring the conscious state of nonhuman primates (NHPs) or NHP models with loss of consciousness (LoC), which is expected to facilitate future research into the underlying mechanisms of consciousness.
