The type of SARS-CoV-2 vaccine does not affect ovarian function in assisted

Objective: To assess whether vaccination or the type of vaccine against SARS-CoV-2 affects ovarian function in an assisted reproduction treatment.Design: A retrospective and observational study. Setting: University-affiliated private in vitro fertilization (IVF) center.Patient(s): Five hundred one patients who had received the complete vaccination schedule.Intervention(s): Treatment before and after vaccination.Main Outcome Measure(s): Parameters for both reproductive outcomes and IVF results in patients vaccinatedResult(s): We included 510 patients, distributed as follows: 13.5% (n = 69) received a viral vector vaccine, either the adenovirus serotype 26 vector vaccine (Ad26.CoV2.S; Janssen; n = 31) or the chimpanzee adenovirus vector vaccine (ChAdOx; AstraZeneca; n = 38). The remaining 86.5% (n = 441) received an messenger RNA vaccine from either Pfizer-BioNTech (n = 336) or Moderna (n = 105). Sample size for the unexposed women was n = 1190. No differences were found in any of the evaluated parameters for both reproductive outcomes and IVF results in patients vaccinated with any adenovirus or messenger RNA vaccine. When we compared the results after vaccination with different types of vaccines between the exposed and unexposed groups, and similar results were obtained in the days of stimulation or the doses of administered follicle stimulating hormone. Finally, the numbers of oocytes were as follows: Johnson & Johnson (9.2 +/- 2.6), AstraZeneca (7.7 +/- 1.2), Moderna (11.3 +/- 1.8), Pfizer (12.6 +/- 1.0), and the unvaccinated group (10.2 +/- 1.5), P=0.057. Conclusion(s): These early results suggest no measurable detrimental effect on reproductive outcomes, regardless of the type of vaccine received. (Fertil Sterile 2023;119:618-23.(c) 2022 by American Society for Reproductive Medicine.) El resumen esta disponible en Espanol al final del articulo.

Automated summary

This retrospective observational study aimed to assess the impact of SARS-CoV-2 vaccination and different types of vaccines on ovarian function in assisted reproduction treatment. The results showed no adverse effects on reproductive outcomes regardless of receiving adenovirus or mRNA vaccines.