Kaempferol suppression of acute colitis is regulated by the efflux transporters BCRP and MRP2

Kaempferol acts on bile acid signaling and gut microbiota to attenuate the tumor burden in ApcMin/+ mice

(2022) Xiaoyan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer

(2020) Xiaoyan Li et al.   PeerJ

Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice

(2017) Jiamei Chen et al.   MOLECULAR PHARMACEUTICS

In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters

(2016) Liang Zheng et al.   AAPS Journal

MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux

(2015) Robert D. Barrington et al.   BIOCHEMICAL PHARMACOLOGY

Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method

(2014) Tongmeng Yan et al.   PHARMACEUTICAL RESEARCH

Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC–MS/MS method determines its turnover number and correlates with its glucuronidation activities

(2013) Beibei Xu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A Novel Local Recycling Mechanism That Enhances Enteric Bioavailability of Flavonoids and Prolongs Their Residence Time in the Gut

(2012) Bijun Xia et al.   MOLECULAR PHARMACEUTICS

Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice

(2011) Mi-Young Park et al.   DIGESTIVE DISEASES AND SCIENCES

Breast Cancer Resistance Protein (BCRP) and Sulfotransferases Contribute Significantly to the Disposition of Genistein in Mouse Intestine

(2010) Wei Zhu et al.   AAPS Journal

Disposition of soy isoflavones in normal human breast tissue

(2010) Selin Bolca et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Disposition of Naringenin via Glucuronidation Pathway Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides

(2009) Haiyan Xu et al.   MOLECULAR PHARMACEUTICS

Variable Isoflavone Content of Red Clover Products Affects Intestinal Disposition of Biochanin A, Formononetin, Genistein, and Daidzein

(2008) Stephen W.J. Wang et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

(2008) K. van de Wetering et al.   MOLECULAR PHARMACOLOGY