Article
Cell Biology
Dongliang Liu, Xiaofang Zeng, Le Li, Zheng-Lin Ou
Summary: The study demonstrates that L-carnitine can improve oxidative stress recovery and prolong lifespan in C. elegans, with its uptake being associated with a new gene T08B1.1, which may play an important role in healthy aging.
Article
Environmental Sciences
Yang Shi, Xiangzhou Meng, Jing Zhang
Summary: Ionic liquids (ILs) have emerged as pollutants, prompting studies on their long-term effects. Research on the multi-generational and trans-generational effects of 1-butylpyrinium chloride ([bpyr]Cl) on C. elegans showed oscillating impacts on reproduction and lifespan, as well as fluctuations in pro/antioxidant status. This suggests a need for further investigation into the long-term influence and epigenetic explanations of ILs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Jihao Mo, Zhenzhen Zhang, Xiaowei Wang, Miaomiao Wang, Ning Sun, Lei Wang, Meimei Wang
Summary: A high glucose diet extends the lifespan of aged worms dependent on oxidative stress resistance. The highly expressed genes gpdh-1 and col-92 are associated with oxidative stress response in worms fed high glucose diet. Intestinal gpdh-1 is essential for the lifespan extension induced by high glucose diet in aged worms.
Article
Food Science & Technology
Hui Shi, Xuqiao Hu, Hang Zheng, Chunlei Li, Lianli Sun, Zhongyi Guo, Weijuan Huang, Rongmin Yu, Liyan Song, Jianhua Zhu
Summary: Two novel antioxidant peptides, D2-G1S-1 and G2-G1S-2, identified from Arca subcrenata exhibited potent antioxidant activities, extending the mean lifespan of Caenorhabditis elegans and improving age-associated physiological functions. These peptides could potentially be developed as cosmetics additives.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Ting Wang, Mei Jing, Ting Zhang, Zaijun Zhang, Yewei Sun, Yuqiang Wang
Summary: TBN can extend the lifespan of C. elegans, promote age-related health indicators, restore mitochondrial function, and significantly reduce ROS levels and superoxide accumulation in C. elegans.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qian Wang, Jingsong Wu, Jing Huang, Lijun Yang, Jin Tao, Jintao Nie, Jiayuan Zhao, Ya-nan Wang
Summary: Cremastra appendiculata polysaccharide (CAP) has potential anti-aging and stress resistance effects. CAP primarily comprises mannose and glucose and exhibits antioxidant activity in vitro. In vivo, CAP prolongs the lifespan of Caenorhabditis elegans in a concentration-dependent manner and enhances antioxidant enzyme activity and stress resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Monira Pervin, Keiko Unno, Tomokazu Konishi, Yoriyuki Nakamura
Summary: The study showed that dietary L-arginine can reduce stress-induced brain damage and slow down aging in psychosocially stress-loaded senescence-accelerated (SAMP10) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Gaku Yamanaka, Shinji Suzuki, Natsumi Morishita, Mika Takeshita, Kanako Kanou, Tomoko Takamatsu, Shinichiro Morichi, Yu Ishida, Yusuke Watanabe, Soken Go, Shingo Oana, Hisashi Kawashima
Summary: Riboflavin, a member of the B-vitamin family, plays a vital role in preventing migraines by reducing inflammation and oxidative stress. Experimental and clinical evidence have shown that riboflavin can lower levels of oxidative stress markers in migraineurs, suggesting its neuroprotective effects.
Article
Biochemistry & Molecular Biology
Telma S. S. Martins, Rafaela S. S. Costa, Rita Vilaca, Carolina Lemos, Vitor Teixeira, Clara Pereira, Vitor Costa
Summary: Niemann-Pick type C1 (NPC1) is a transmembrane protein involved in the transport of cholesterol and sphingolipids. In this study, the researchers found that the loss of Ncr1 in yeast cells led to changes in cellular functions related to vesicle biology, autophagy, and ion homeostasis. Furthermore, iron overload was found to impair autophagy, increase oxidative stress sensitivity, and induce cell death in the yeast model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui
Summary: This study found that the natural non-nutritive sweetener Reb A can extend the lifespan and healthspan of C. elegans by reducing cellular reactive oxygen species levels and attenuating neutral lipid accumulation with aging. Reb A acts as an effective cellular antioxidant and lowers the ectopic accumulation of neutral lipids, which contributes to its anti-aging effects.
Article
Biology
Deepashree Sheshadri, Akanksha Onkar, Subramaniam Ganesh
Summary: Sexual dimorphism in lifespan is controlled by multiple physiological processes, with glycogen playing a key role in aging. Using transgenic fly lines, this study found that altered levels of glycogen in the brain of Drosophila melanogaster females result in different survival and stress responses compared to males. This provides new insight into the sex-specific effects of glycogen on survival and aging.
Article
Geriatrics & Gerontology
Saswat Kumar Mohanty, Kitlangki Suchiang
Summary: The study found that T3 could increase the mRNA expressions of klotho homologous genes in C. elegans, leading to lifespan extension, modulation of oxidative stress resistance, and aging biomarkers. These effects are mediated through the EGL-17/EGL-15 pathway and involve the transcription factor DAF-16. This reveals an unexpected link between T3 and Klotho in modulating the aging process.
Article
Biology
Aleksandra Anatolyevna Istomina, Avianna Fayazovna Zhukovskaya, Andrey Nikolaevich Mazeika, Ekaterina Andreevna Barsova, Victor Pavlovich Chelomin, Marina Alexandrovna Mazur, Olesya Alexandrovna Elovskaya, Andrey Alexandrovich Mazur, Nadezda Vladimirovna Dovzhenko, Yuliya Vladimirovna Fedorets, Alexander Alexandrovich Karpenko
Summary: The fatty acid composition of mitochondrial membranes is related to the lifespan of marine bivalves. The lipid composition of mitochondria affects the sensitivity of the membranes to oxidative damage, which is associated with the maximum lifespan of the species.
Article
Biology
Tatsuya Sato, Jason Solomon Shapiro, Hsiang-Chun Chang, Richard A. Miller, Hossein Ardehali
Summary: Iron is essential but its accumulation can be harmful. The study found that iron accumulation mainly occurs in the brain cortex of aged mice, which is associated with increased expression of hepcidin and decreased iron exporter.
Article
Environmental Sciences
Jerusa Maria de Oliveira, Graziela Domingues de Almeida Lima, Ana Luiza Fonseca Destro, Suellen Condessa, Jener Alexandre Sampaio Zuanon, Mariella Bontempo Freitas, Leandro Licursi de Oliveira
Summary: Research shows that exposure to DTM has harmful effects on the reproductive function of Neotropical fruit-eating bats, potentially leading to cell degeneration. This has important implications for seed dispersal and reforestation in the Neotropical forests.