Article
Clinical Neurology
Jun-Fang Zhang, Jing Jing, Xia Meng, Yuesong Pan, Yi-Long Wang, Xing-Quan Zhao, Jin-Xi Lin, Xin-Sheng Han, Bin-Bin Song, Zheng-Chang Jia, Song-Di Wu, Xiao-Fei Chen, Wen-Jun Xue, Craig S. Anderson, Yun-Cheng Wu, Yong-Jun Wang
Summary: The study found an association between serum phosphate level and 1-year clinical outcomes in patients with acute ischemic stroke and transient ischemic attack, especially in relation to recurrent stroke, composite end point, and poor functional outcome.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anant Naik, Olufunmilola Adeleye, Stefan W. Koester, Ethan A. Winkler, Joelle N. Hartke, Katherine Karahalios, Sandra Mihaljevic, Anupama Rani, Sudhanshu Raikwar, Jarrod D. Rulney, Shashvat M. Desai, Lea Scherschinski, Andrew F. Ducruet, Felipe C. Albuquerque, Michael T. Lawton, Joshua S. Catapano, Ashutosh P. Jadhav, Ruchira M. Jha
Summary: Despite the high incidence and burden of stroke, biological biomarkers are not routinely used for diagnosing, determining progression, or predicting outcomes of acute ischemic stroke (AIS). However, cerebrospinal fluid (CSF) shows potential as a valuable source for biomarker development due to its direct interface with neural tissue. This systematic review identified 21 biomarkers and other multiomic proteomic markers, including S100B, inflammatory markers, and free fatty acids, that have been studied frequently. CSF has been shown to be an effective medium for acquiring biomarkers for AIS, although more large-scale trials studying the efficacy of biomarkers in altering clinical management are still needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
MinJung Jang, SoHyun Han, HyungJoon Cho
Summary: This study quantitatively measured CSF flow and volume using MRI and observed the changes in CSF dynamics through Monte Carlo simulations. Longitudinal monitoring showed a strong positive correlation between CSF peak velocity and diffusion signals, and a positive correlation between ventricular CSF volume and D* in lateral and ventral-third ventricles.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Hongfeng Wen, Di Jin, Lina Cai, Tao Wu, Haichao Liu
Summary: Neurobrucellosis can present symptoms similar to stroke and transverse myelitis. It is a treatable infectious disease that should be considered in differential diagnosis, especially when there are risk factors.
Article
Geriatrics & Gerontology
Liang Jiang, Chuanyang Zhang, Siyu Wang, Zhongping Ai, Tingwen Shen, Hong Zhang, Shaofeng Duan, Xindao Yin, Yu-Chen Chen
Summary: This study applied MRI radiomics features to predict edema after acute ischemic stroke. By extracting features from infarction and cerebrospinal fluid (CSF) and developing models with two different feature sets, the Bayesian model based on DWI + CSFFLAIR and the random forest model based on DWI + CSFDWI showed the best performance and stability.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Patrizia Natali, Roberta Bedin, Gaetano Bernardi, Elena Corsini, Eleonora Cocco, Lucia Schirru, Ilaria Crespi, Marta Lamonaca, Arianna Sala, Cinzia Nicolo, Massimiliano Di Filippo, Alfredo Villa, Viviana Nociti, Teresa De Michele, Paola Cavalla, Paola Caropreso, Francesca Vitetta, Maria Rosaria Cucinelli, Matteo Gastaldi, Tommaso Trenti, Patrizia Sola, Diana Ferraro
Summary: This study assessed the concordance of CSF and serum KFLC measurements, and K-Index values, across different laboratories. The results showed excellent agreement in CSF KFLC measurements across all laboratories, good agreement in serum KFLC measurements between B and S laboratories, and decreased agreement when including a mixed laboratory. The concordance for a positive K-Index was substantial across all laboratories, indicating consistent results regardless of testing in different laboratories or using different platforms/assays.
Article
Neurosciences
Qin Xu, Lele Hu, Lu Chen, Hao Li, Xue Tian, Yingting Zuo, Yijun Zhang, Xiaoli Zhang, Ping Sun, Yongjun Wang, Xia Meng, Anxin Wang
Summary: The aim of this study was to investigate the association between serum magnesium and all-cause mortality and poor functional outcome after stroke. The study found that low serum magnesium levels were associated with an increased risk of poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Sophie Stukas, Jennifer Cooper, Jasmine Gill, Nader Fallah, Michael A. Skinnider, Lise Belanger, Leanna Ritchie, Angela Tsang, Kevin Dong, Femke Streijger, John Street, Scott Paquette, Tamir Ailon, Nicolas Dea, Raphaele Charest-Morin, Charles G. Fisher, Christopher S. Bailey, Sanjay Dhall, Jean-Marc Mac-Thiong, Jefferson R. Wilson, Sean Christie, Marcel F. Dvorak, Cheryl L. Wellington, Brian K. Kwon
Summary: This study aims to evaluate the response of neurofilament light (NF-L) and glial fibrillary acidic protein (GFAP) in patients with acute spinal cord injury (SCI) to objectively characterize injury severity and predict neurological recovery. The results show that NF-L and GFAP levels are associated with injury severity and can differentiate between different levels of injury. The concentration of serum NF-L and GFAP within 72 hours can predict neurological recovery at 6 months. These findings are valuable for patient stratification in clinical trials and prognostication.
Article
Cell Biology
Guomei Shi, Minghao Li, E. Yan, Meng Wang, Pengyu Gong, Xiaorong Wang, Jingye Lu, Weixiang Wu, Shouru Xue, Junshan Zhou, Rujuan Zhou
Summary: The study aimed to investigate the association between serum YKL-40 levels at admission and one-year clinical outcomes in Chinese AIS patients. The findings suggested that elevated serum YKL-40 levels were independently associated with one-year poor outcome and all-cause mortality, but not stroke recurrence.
Article
Clinical Neurology
Xiaohong Sun, Jie Lv, Zhenghuan Wu, Jun Shi, Hongwei Huang
Summary: This study found that serum uric acid to serum creatinine ratio (SUA/SCr) is positively associated with the risk of stroke recurrence among young adults with ischemic stroke.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Neurosciences
P. N. Sylaja, Sruthi S. Nair, Jeyaraj Pandian, Dheeraj Khurana, M. V. Padma Srivastava, Subhash Kaul, Deepti Arora, P. Sankara Sarma, Aneesh B. Singhal
Summary: This study examined the impact of pre-stroke anti-platelet (PAP) therapy on severity and outcomes after ischemic stroke, finding no significant association between PAP therapy and initial stroke severity, in-hospital mortality, stroke recurrence, and 3-month outcomes.
Article
Neurosciences
Siqi Li, Anxin Wang, Xue Tian, Yingting Zuo, Xia Meng, Yumei Zhang
Summary: This study demonstrated that elevated GGT levels were positively associated with an increased risk of stroke adverse outcomes, namely, recurrence, ischemic stroke, and combined vascular events.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Veterinary Sciences
Renee M. Barber, Simon R. Platt, Luisa De Risio, Jamie Barber, Kelsey R. Robinson
Summary: This study evaluated the levels of pro- and anti-inflammatory cytokines in dogs with stroke and found that CXCL1 and MCP-1 concentrations were significantly elevated, suggesting their potential role in canine stroke and future research targets.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kornelia Laichinger, Paula Bombach, Jutta Duenschede, Christoph Ruschil, Maria-Ioanna Stefanou, Evelyn Dubois, Sven Poli, Katharina Feil, Ulf Ziemann, Markus Kowarik, Annerose Mengel
Summary: In this study, the prevalence of intrathecal IgG synthesis and B cell activation in AIS patients was determined. It was found that 5.7% of patients had intrathecal IgG synthesis, and one third of these patients had concurrent chronic inflammatory CNS disease. No significant correlation was found with stroke characteristics.
Article
Oncology
Ruixia Zhu, Yating Zhao, Dandan Tian, Na Guo, Chenguang Zhang, Xu Liu
Summary: This study identified PTCH1 rs2236406 as significantly associated with functional outcome after stroke and ABO rs532436 as correlated with increased risk of stroke recurrence. Functional annotation analysis revealed that these two loci can change regulatory motif and transcription factor binding capacity of related genes.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)